РЕГУЛЯТОРНЫЕ Т-ЛИМФОЦИТЫ В ИММУННОМ ОТВЕТЕ НА ИНФЕКЦИЮ
https://doi.org/10.22625/2072-6732-2011-3-1-6-13
Аннотация
Обзор содержит современные сведения о регуляторных Т-лимфоцитах (Treg), контролирующих воспалительные реакции и специфический иммунный ответ на внедрение инфекции. Описаны разновидности регуляторных Т-клеток, механизмы их активации и воздействия на клетки-мишени. Подчеркивается двойственная роль Treg в патогенезе инфекций.
Об авторе
Г. Ф. Железникова
Научно-исследовательский институт детских инфекций ФМБА России, Санкт-Петербург
Россия
Россия
руководитель отдела клинической лабораторной диагностики Научно-исследовательского института детских инфекций, д.м.н., профессор
Список литературы
1. Chabenoud, I. Supressor T cells – they are back and critical for regulation of autoimmunity / I. Chabenoud, B. Salomon, J. Bluestone // mmunol. Rev. – 2001. – V. 182. – P. 149–163.
2. Annacker, O. On the ontogeny and phisiology of regulatory T cells / O. Annacker, R. Pimenta-Araujo, O. Burlen- Defra noux // Immunol. Rev. – 2001. – V. 182. – P. 5–17.
3. Sakaguchi, S. Immunologic tolerance maintained by CD25+CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance / S. Sakaguchi, N. Sakaguchi, J. Shimizu // Immunol. Rev. – 2001. – V. 182. – P. 18–32.
4. Shevach, E. Control of T cell activation by CD4+CD25+ suppressor T cells / E. Shevach [et al.] // Immunol. Rev. –2001. – Vol. 182. – P. 58-67.
5. Ярилин, А.А. Естественные регуляторные Т-клетки и фактор FOXP3 / А.А. Ярилин, А.Д. Донецкова // Иммунология. – 2006. – № 3. – С. 176–188.
6. Ralainirina, N. Control of NK cell functions by CD4+CD25+regulatory T cells / N. Ralainirina, A. Poli, T. Michel // J. Leukoc. Biol. – 2007. – V. 81, № 1. – P. 144–153.
7. Воробьев, А.А. Роль клеток-регуляторов CD4+CD25+в развитии хронических инфекционных заболеваний / А.А. Воробьев, С.Н. Быковская, Е.П. Пашков // Вестник Рос. АМН. – 2006. – № 9–10. – С. 24–29.
8. Chen, W. CD4+CD25+ T regulatory cells and TGF-beta in mucosal immune system: the good and the bad / W. Chen,S. Perruche, J. Li // urr. Med. Chem. – 2007. – V. 14, № 21. – P. 2245–2249.
9. Cassis, L. Natural versus adaptive regulatory T cells /L. Cassis, S. Aiello, M. Noris // Contrib. Nephrol. – 2005. –V. 146. – P. 121–131.
10. Gurk, P. Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases / P. Gurk, K. Mills // Trends in Immunol. – 2002. – V. 23, № 9. – P. 450–455.
11. Weiner, H. Induction and mechanism of action of TGF- β-secreting regulatory cells / H. Weiner // Immunol. Rev. –2001. – V. 182. – P. 207–214.
12. Trinchieri, G. Interleukin-10 production by effector T cells: Th1 cells show self control / G. Trinchieri // J. Exp. Med. – 2007. – V. 204, № 2. – P. 239–243.
13. Lu, L. Generation and regulation of CD8+ regulatory T cells / L. Lu, H. Cantor // Cell. Mol. Immunol. – 2008. – № 6. – P. 401–406.
14. Mauri, C. The ‘short’ history of regulatory B cells /C. Mauri, M. Ehrenstein // Trends Immunol. – 2008. – № 1. – P. 34–40.
15. Rouse, B. Regulatory T cells and immunity to pathogens /B. Rouse, S. Suvas // Expert. Opin. Biol. Ther. – 2007. –№ 9. – P. 1301–1309.
16. Сорокина М.Н. Вирусные энцефалиты и менингиты у детей / М.Н. Сорокина [и др.]. – М.: Медицина, 2004. –416 с.
17. Kawamura, K. Virus-stimulated plasmacytoid dendritic cells induce CD4+ cytotoxic regulatory T cells / K. Kawamura [et al.] // Blood. – 2006. – V. 107, № 3. – P. 1031–1038.
18. Zu, Y. Roles of CD8+CD28– T regulatory cells in acute infectious mononucleosis in children / Y. Zu [et al.] // Zhongua Er Ke Za Zhi. – 2007. – V. 45, № 3. – P. 208–211.
19. Carpentier, A. Increased expression of regulatory Tr1 cells in recurrent hepatitis C after liver transplantation / A. Carpentier [et al.] // Am. J. Transplant. – 2009. – № 9. – P. 2102–2112.
20. Li, L. Increased frequency of CD4+CD25(high) Treg cells inhibit BCG-specific induction of IFN-γ by CD4+T cells from TB patients / L. Li, S. Lao, C. Wu // Tuberculosis (Edinb.) – 2007. – V. 87, № 6. – P. 526–534.
21. Li, L. CD4+CD25+ Treg cells inhibit human memory γδT cells to produce IFN-γ in response to Mycobacterium tuberculosis antigen ESAT-6 / L. Li, C. Wu // Blood. – 2008. – V. 111, № 12. – P. 5629–5636.
22. Madura, L. BCG stimulated dendritic cells induce an IL-10 producing T-cell population with no T helper 1 or T helper 2 bias in vitro / L. Madura [et al.] // Immunology. – 2007. – V. 121, № 2. – P. 276–282.
23. Wisnoski, N. The contribution of CD4+CD25+ T-regulatory cells to immune suppression in sepsis / N. Wisnoski [et al.] // Shock. – 2007. – V. 27, № 3. – P. 251–257.
24. Scumpia, P. Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis / P. Scumpia [et al.] //J. Immunol. – 2006. – V. 177, № 11. – P. 7943–7949.
25. Heuer, J. Adoptive transfer of in vitro-stimulated CD4+CD25+ regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis / J. Heuer [et al.] // J. Immunol. – 2005. – V. 174, № 11. – P. 7141–7146.
26. Venet, F. Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism / F. Venet [et al.] //J. Immunol. – 2006. – V. 177, № 9. – P. 6540–6547.
27. Fujita, S. Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response / S. Fujita [et al.] // Blood. – 2006. – V. 107, № 9. – P. 3656–3664.
28. Netea, M. Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells / M. Netea [et al.] // J. Immunol. – 2004. – V. 172, № 6. – P. 3712–3718.
29. Cavassani, K. Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans / K. Cavassani [et al.] // J. Immunol. – 2006. – V. 177, № 9. – P. 5811–5818.
30. Mitre, E. CD4+ (and not CD25+) T cells are the predominant IL-10-producing cells in the circulation of filariainfected patients / E. Mitre, D. Chien, T. Nutman // J. Infect. Dis. – 2008. – V. 197, № 1. – P. 94–101.
31. Wong, K. Plasmodium infection and endotoxic shock induce the expansion of regulatory dendritic cells / K. Wong, A. Rodriguez // J. Immunol. – 2008. – V. 180, № 2. – P. 716– 726.
32. Couper, K. Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic Toxoplasma gondii infection / K. Couper [et al.] // J. Immunol. – 2009. – V. 182, № 7. – P. 3985–3994.
Рецензия
Для цитирования:
Железникова Г.Ф. РЕГУЛЯТОРНЫЕ Т-ЛИМФОЦИТЫ В ИММУННОМ ОТВЕТЕ НА ИНФЕКЦИЮ. Журнал инфектологии. 2011;3(1):6-13. https://doi.org/10.22625/2072-6732-2011-3-1-6-13
For citation:
Zheleznikova G.F. Regulatory t cells in immune response to infection. Journal Infectology. 2011;3(1):6-13. (In Russ.) https://doi.org/10.22625/2072-6732-2011-3-1-6-13
Просмотров: 738
.png)
.png)
Послать статью по эл. почте 