Clinical case of combined intestinal infection caused by enteroaggregative Escherichia coli and toxigenic strain Clostridium difficile in a child with cystic fibrosis
https://doi.org/10.22625/2072-6732-2021-13-3-143-149
Abstract
The goal is to study the peculiarities of the clinical picture and the distant outcome of intestinal infection due to enteroaggregative escherichiosis and the toxigenic strain of C. difficile in a child with cystic fibrosis.
Material and methods. To verify the etiology of intestinal infection, the following studies were conducted. — fecal PCR “OKI-screen” tests to detect viral and bacterial pathogens, fecal bacteriopsy for pathogenic and opportunistic microbes; determination of C. difficile A and B toxins in feces by enzyme-linked fluorescence analysis.
Results. The combined intestinal infection caused by en-teroaggregative escherichiosis and a toxigenic strain of C. difficile, in a child with pulmonary-intestinal form of cystic fibrosis was characterized by a wavy course, a pronounced intoxication syndrome, excicosis, hemorrhagic enterocolitis, signs of systemic and local inflammation, metabolic disorders. There were no recurrences of C. difficile-infection in catamnese.
Conclusion. It is necessary to continue research on the course of intestinal infections caused by bacterial associations of pathogens.
About the Authors
N. V. Gonchar
Pediatric Research and Clinical Center for Infectious Diseases; North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Competing Interests:
Russian Federation
Saint Petersburg.
Competing Interests:
No
O. I. Klimova
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation
Competing Interests:
Russian Federation
Saint Petersburg.
Competing Interests:
No
I. V. Razd'yakonova
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation
Competing Interests:
Russian Federation
Saint Petersburg.
Competing Interests:
No
A. V. Orlov
North-Western State Medical University named after I.I. Mechnikov; St. Olga Children's city hospital № 4
Russian Federation
Competing Interests:
Russian Federation
Saint Petersburg.
Competing Interests:
No
A. S. Kvetnaya
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation
Competing Interests:
Russian Federation
Saint Petersburg.
Competing Interests:
No
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Review
For citations:
Gonchar N.V., Klimova O.I., Razd'yakonova I.V., Orlov A.V., Kvetnaya A.S. Clinical case of combined intestinal infection caused by enteroaggregative Escherichia coli and toxigenic strain Clostridium difficile in a child with cystic fibrosis. Journal Infectology. 2021;13(3):143-149. (In Russ.) https://doi.org/10.22625/2072-6732-2021-13-3-143-149
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