Immunological efficacy of Vaccination against Measles in Children with Down syndrome
https://doi.org/10.22625/2072-6732-2011-3-4-111-115
Abstract
The data of current vaccination process of cellular, humoral immunity and specific antibody formation in 41 children with Down syndrome at the age of 1 year to 6 years old is observed. To prevent easles used measles vaccine (n=12), divaccine -measles-mumps (n=21) and or Priorix vaccine (n=8). The comparison group consisted of 63 children without Down syndrome. The post-vaccination period in 97,6% of children with Down syndrome cases are asymptomatic, only 2,4% of children mentioned layering of intercurrent diseases. The immunological status in children with Down syndrome is characterized by a significant decrease in the umber leucocytes, lymphocytes, CD3+, CD4+, CD8+ and absolute number of CD20+, but functional activity of the cells is preserved. By 30 days after immunization they have increased leucocytes, lymphocytes, CD 95+cells. The number of antibodies significantly increased (6,63±0,33 compared to 5,79±0,32 log2, р < 0,05).
About the Authors
S. P. Kaplina
Specialized Neuropsychiatric Orphanage № 13 of St. Petersburg, Saint-Petersburg
Russian Federation
Russian Federation
S. M. Kharit
Federal state institute Research institute child infection diseases of the Federal Medical Biological Agency of Russia, Saint-Petersburg
Russian Federation
Russian Federation
E. I. Alexandrova
Medical Autonomous Nonprofit Organization «Health Center of St. Petersburg State University», Saint-Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Kaplina S.P., Kharit S.M., Alexandrova E.I. Immunological efficacy of Vaccination against Measles in Children with Down syndrome. Journal Infectology. 2011;3(4):111-115. (In Russ.) https://doi.org/10.22625/2072-6732-2011-3-4-111-115
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