ТHE LEVEL OF ANTIBODIES TO THE INFLUENZA VIRUS IN PREGNANT WOMEN VACCINATED WITH SUBUNIT VACCINE
https://doi.org/10.22625/2072-6732-2017-9-4-69-75
Abstract
Aim: to study the level of antibodies to strains of the influenza virus in trivalent vaccine, in pregnant women vaccinated in different trimester of the gestation. Materials and methods: according to CPMP criteria the level of postvaccinal antibodies to the strain of influenza A and B virus was determined by the hemagglutination inhibition reaction in sera of 48 women vaccinated in the second and third trimester of gestation. Results: in 1 month after vaccination against influenza in pregnant women the level of the seroprotection, seroconversion and the factor of the seroconversion increased in accordance with CPMP requirements. In six months after the birth, the protective titer of antibodies to different strains was registered in 30,4–70,2% of women wich was vaccinated in second trimester and 52,4–66,7% in the third trimester of gestation. Conclusion: the level of the postvaccination antibodies to influenza virus (except for the strain A / H3N2 / in vaccinated in the second trimester) in pregnant women met the criteria for CPMP irrespective of the trimester of gestation.
About the Authors
M. P. Kostinov
Science Research Institute of Vaccines and Sera named after I.I. Mechnikov; First Moscow State Medical University named after I.M. Sechenov.
Russian Federation
Moscow.
Russian Federation
Moscow.
A. P. Cherdantsev
Ulyanovsk State University.
Russian Federation
Ulyanovsk.
Russian Federation
Ulyanovsk.
A. D. Shmitko
Science Research Institute of Vaccines and Sera named after I.I. Mechnikov.
Russian Federation
Moscow.
Russian Federation
Moscow.
A. D. Protasov
Samara State Medical University.
Russian Federation
Samara.
Russian Federation
Samara.
V. B. Polischuk
Science Research Institute of Vaccines and Sera named after I.I. Mechnikov.
Russian Federation
Moscow.
Russian Federation
Moscow.
Yu. N. Dementieva
Ulyanovsk State University.
Russian Federation
Ulyanovsk.
Russian Federation
Ulyanovsk.
A. M. Kostinova
Institute of Immunology.
Russian Federation
Moscow.
Russian Federation
Moscow.
D. A. Praulova
National Scientific Clinical Centre of Pediatric Hematology, Oncology, Immunology named after Dmitry Rogachev.
Russian Federation
Moscow.
Russian Federation
Moscow.
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Review
For citations:
Kostinov M.P., Cherdantsev A.P., Shmitko A.D., Protasov A.D., Polischuk V.B., Dementieva Yu.N., Kostinova A.M., Praulova D.A. ТHE LEVEL OF ANTIBODIES TO THE INFLUENZA VIRUS IN PREGNANT WOMEN VACCINATED WITH SUBUNIT VACCINE. Journal Infectology. 2017;9(4):69-75. (In Russ.) https://doi.org/10.22625/2072-6732-2017-9-4-69-75
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