Neurological aspects at children with a perinatal HIV-infection
https://doi.org/10.22625/2072-6732-2010-2-1-18-27
Abstract
In the given research results of inspection of children with a HIV-infection are analyzed at perinatal ways. 550 children from a birth till 10 years are surveyed. The neurological status of patients, the data immunological and virologic inspection of plasma and cerebrospinal fluid is studied. It is spent neuroimaging and psychometric testing. It is shown that defeat of nervous system is HIV-infection display at children’s age. A HIV-induced defeat of the central and peripheral nervous system is presented, first of all, to specific HIV-encephalitis with sharp and sub acute a current. Are revealed clinical and immunological correlations at various stages of infectious process, influence antiretroviral therapies on dynamics of neurological infringements is analyzed.
About the Authors
M. Yu. FominaRussian Federation
E. E. Voronin
Russian Federation
References
1. ВИЧ-инфекция и СПИД: клинические рекомендации / под ред. В.В.Покровского. – М.: ГЭОТАР Медиа, 2006. – 128 с.
2. Воронин, Е.Е. О критериях диагностики и прогноза ВИЧ-инфекции у детей первого года жизни и особенностях их лечения / Е.Е. Воронин, Л.Ю. Афонина, Ю.А. Фомин; под. ред. А.Г. Рахмановой // ВИЧ-инфекция. – СПб.: Питер, 2004. – С. 594–635.
3. Сивителло, Л. Неврологические расстройства /Л. Сивителло // Руководство по оказанию помощи ВИЧ-инфи цированным детям, под. ред. С. Зайхера, Д. Рид / пер. с анл. – 2005. – Т. 2. – С. 26.1– 26.14.
4. Уолтерс, П. Нервно-психические нарушения у ВИЧ- инфицированных детей и подростков / П. Уолтерс, П. Брауэрс // Руководство по оказанию помощи ВИЧ- инфицированным детям, под. ред. С. Зайхера, Д. Рид / пер. с анл. – 2005. – Т. 1. – С. 17.1– 17.14.
5. Age-dependent neurologic manifestations of HIV infection in childhood / L. Angelin [et al.] // Neurol Sci. –2000. – Jun; 21(3). – P. 135– 142.
6. Brouwers, P. Correlation between computed tomographic brain scan abnormalities and neuropsychological function in children with symptomatic HIV disease / P. Brouwers, C. DeCarly, L. Civitello // Arch. Neurol. 52. – 1995. – P. 39–44.
7. Cerebrospinal fluid viral load is related to cortical atrophy and not to intracerebral calcifications in children with symptomatic HIV disease / P. Brouwers [et al.] // J Neurovirol. – 2000. – Oct; 6(5). – P. 390–397.
8. Cherner, M. Neurocognitive dysfunction predicts postmortem findings of HIV encephalitis / M. Cherner, E. Masliah, R.J. Ellis // Neurology. – 2002. – 59. – P. 1563–1567.
9. Correlation of viral load and CD8 T-lymphocytes with development of neurological manifestations in vertically HIV-1-infected infants. A prospective longitudinal study / D. Gurbindo [еt al] // Neuropediatrics. – 1999. – Aug; 30(4). – P. 197– 204.
10. Cysique, L.A. The neuropsychological and neurologic impact of HCV co-infection on HIV-infected subjects / L.A. Cysique, B.J. Brew, M. Halman // AIDS. – 2005. – 19(suppl 3): P. 64–71.
11. Czornyj, LA. Encephalopathy in children infected by vertically transmitted human immunodeficiency virus / L.A. Czornyj // Rev Neurol. – 2006. – Vol. 4, N12. – P. 743– 753.
12. Davis, F.J. Language and oral-motor development and disorders in infants and young toddlers with human immunodeficiency virus / F.J. Davis, E. Mc Farland // Semin Speech Lang. – 2000; 21(1): 19-34. – P. 34–35.
13. Palmer, A. Neurologic disease in HIV-1 infected children / A. Palmer // University of Mississippi Medical Center, Jackson, USA. HIV Clin. – 2002. – Spring; 14(2):1. – P. 5–7.
14. Sacktor, N. Multicenter AIDS Cohort Study. Response to systemic HIV viral load suppression correlates with psychomotor speed performance / N. Sacktor [et al] // Neurology. – 2003. – 61. – P. 567– 569.
Review
For citations:
Fomina M.Yu., Voronin E.E. Neurological aspects at children with a perinatal HIV-infection. Journal Infectology. 2010;2(1):18-27. (In Russ.) https://doi.org/10.22625/2072-6732-2010-2-1-18-27