Research of a level cytokines-serum patients with the tuberculosis associated from a HIV
https://doi.org/10.22625/2072-6732-2009-1-2,3-31-35
Abstract
In the present work the data of comparative studying the cytokine status (serum concentration and spontaneous production IL-4, IFN-g, TNF-a) at HIV-infected and HIV-non infected persons with the active for the first time revealed tuberculosis, and also an establishment of possible interrelation between these parameters and amount of virus loading, level CD4+T-cell in blood of HIV- infecte patients from TB (group HIV/TB). In process of progressing associated HIV/ТВ infections and development of heavier forms of TB the increase serum content IFN-g and TNF-a testifying about displacement of balance aside increases proinflammatory cytokines on a background of decrease in number CD4+T-cell, increase of virus loading of a HIV is marked. The received results testify about immunosupreses with an exhaustion of functional reserves mononuclear cells of the peripheral blood aggravated in process of progressing of disease, being one of pathogenetic mechanisms of formation of secondary diseases, both virus, and the bacterial nature.
About the Authors
E. V. Makasheva
Research Institute of Children’s Infections of Federal Medico-Biology Agency, St.-Petersburg
Russian Federation
Russian Federation
O. N. Konanchuk
The regional center on preventive maintenance and struggle about other infectious diseases, Kemerovo
Russian Federation
Russian Federation
E. V. Morozova
The regional center on preventive maintenance and struggle about other infectious diseases, Kemerovo
Russian Federation
Russian Federation
A. V. Panasenko
The regional center on preventive maintenance and struggle about other infectious diseases, Kemerovo
Russian Federation
Russian Federation
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Review
For citations:
Makasheva E.V., Konanchuk O.N., Morozova E.V., Panasenko A.V. Research of a level cytokines-serum patients with the tuberculosis associated from a HIV. Journal Infectology. 2009;1(2,3):31-35. (In Russ.) https://doi.org/10.22625/2072-6732-2009-1-2,3-31-35
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