Clinical laboratory characteristic of hospitalized patients with HBsAg negative chronic hepatitis B
https://doi.org/10.22625/2072-6732-2014-6-2-55-58
Abstract
One of the phases of the natural course of chronic hepatitis В is «HBsAg negative» phase, the clinical and prognostic significance of which is not defined yet. The frequency of HBsAg negative phase of chronic hepatitis В among the hospitalized patients of Clinical Infectious Diseases Hospital named by S.P. Botkin (Saint-Petersburg), for the period of 2010–2012 was assessed in this study. We analyzed the age structure of the patients, their clinical-laboratory inde[es and set the frequency of cirrhotic stage of disease. The «HBsAg negative» phase is revealed among quarter of patients with chronic hepatitis В the middle aged group (45–59 years old). The 84 (67,2%) hospitalized patients with HBsAg negative chronic hepatitis В diagnosed were given a diagnosis of cirrhotic stage disease. Thus, the spontaneous clearance of HBsAg from blood serum is not always the evidence of the prognostically favorable course of chronic hepatitis B.
About the Authors
E. O. Shibaeva
Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russia
Russian Federation
Russian Federation
M. V. Ponyatishina
Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russia
Russian Federation
Russian Federation
I. V. Khomchenko
Clinical Infectious Diseases Hospital named after S.P. Botkin, Saint-Petersburg, Russia
Russian Federation
Russian Federation
O. E. Nikitina
Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russia
Russian Federation
Russian Federation
References
1. Virusnye gepatity v Rossiyskoy Federatsii. Analiticheskiy obzor. 9 vypusk [Viral hepatitis in the Russian Federation. Analytical review. issue 9] pod red. V.I. Pokrovskogo, A.B. Zhebruna.- SPb.: FBUN NIIEM im. Pastera; 2013: 6-112 (in Russian).
2. Rakhmanova A.G., Yakovlev A.A. Khronicheskie virusnye gepatity i VICh-infektsiya [Chronic viral hepatitis end HIV infection]. SPb.: Izd-vo VVM, 2011: 7-10 (in Russian).
3. Mikhaylov M. I. Klinicheskaya gepatologiya. – 2009; 1:15-24 (in Russian).
4. European Association for Study of the liver EASL clinical practice guidelines: management of cronic hepatitis B virus infection. J.of Hehatology. 2012; 57:167- 168
5. ChuC., Liaw YF. Hepatitis B surface antigen seroclearance during chronic HBV infection Antivir. Ther . 2010.15(2):133-143.
6. Abdurakhmanov D.T., Chronic hepatitis B i D [Chronic hepatitis B and D] . Geotar- Media, 2010; (in Russian).
7. Zhdanov K.V. Zhurnal infektologii. 2011; 3(4): 18-25 (in Russian).
8. Sugauchi F, Tanaka Y, Kusumoto S, Matsuura K, Sugiyama M, Kurbanov F, Ueda R, Mizokami M. Virological and clinical characteristics on reactivation of occult hepatitis B in patients with hematological malignancy. J Med Virol. 2011; 83(3): 412-8.
9. Ivashkin V.T.. Morozova M.A., Maevskaya M.V., Sokolina I.A, German E.N., Bundina M.V. Rossiyskiy zhurnal gastroenterologii, gepatologii i koloproktologii. 2009; 1: 4- 16 (in Russian).
10. Pawlotsky JM., Dusheiko G., Hatzakis A., et al. Virologic monitoring of hepatitis В virus therapy in clinical trials and practice: recommendations for a standardized approach. Gastroenterol ogy 2008; 134: 405-415.
11. Karev V.E., Lobzin Yu. V, Tsinzerling V. A., Zhurnal infektologii. 2013; 5(1): 91-98 (in Russian).
12. Esaulenko E.V., Nikitina O.E., Poretskova E. A., Pisareva M. M. Zhurnal infektologii. 2012; 4(5): 67-72 (in Russian).
Review
For citations:
Shibaeva E.O., Ponyatishina M.V., Khomchenko I.V., Nikitina O.E. Clinical laboratory characteristic of hospitalized patients with HBsAg negative chronic hepatitis B. Journal Infectology. 2014;6(2):55-58. (In Russ.) https://doi.org/10.22625/2072-6732-2014-6-2-55-58
Views:
871
.png)
.png)
Email this article 