Influence of supplementary immunization activities for adults dynamics of chronic disease HBV-infection and its outcomes
https://doi.org/10.22625/2072-6732-2014-6-1-47-53
Abstract
Purpose: to evaluate the effect of additional vaccination of adult HBV- infection years 2007–2010 on the incidence of chronic hepatitis B and its outcomes on the example of the Kirov region.
Materials and Methods: the evaluation of epidemiological features process in patients with chronic HBV infection in adults, depending on the vaccination carried out on the basis of official data Rospotrebnadzora in Russia and Kirov region on incidence of infectious disease for the period 1999–2012. Diagnosis of chronic hepatitis B was based on clinical and biochemical, instrumental, virological data. Structure outcomes of chronic hepatitis B was studied in 295 patients aged 18–75 years who were hospitalized in the department of viral hepatitis Kirov infectious diseases hospital in 2006–2010.
Results: In the Kirov region tended to decrease the incidence of chronic hepatitis B in adults. Additional adult vaccination against hepatitis B has not led to the expected significant decrease of the number of patients with chronic forms. One reason for this is the low (20,3–64%) of the adult population immunization coverage. Chronic HBV- monoinfected was observed in 17.1% , cirrhosis in the outcome of chronic hepatitis B in 5,4% of cases, in hospital mortality from complications of HBV- cirrhosis was 0,7%. Association virus C and D have increased the total cohort, compared to a mono- infection by 3,8% and 0,5% lethality.
Conclusion: Additional adult vaccination against hepatitis B in the area has led to a slight decrease in the overall incidence of chronic hepatitis B, but has not reduced the incidence of adverse events – cirrhosis and liver- mediated lethality.
About the Authors
S. V. Baramzina
Kirov State Medical academy, Kirov, Russia
Russian Federation
Russian Federation
A. L. Bondarenko
Kirov State Medical academy, Kirov, Russia
Russian Federation
Russian Federation
References
1. Mezhdunarodnyj al’jans po bor’be s gepatitom // Informacionnyj bjulleten’ VOZ. 2012. – № 1
2. Gepatit В //Informacionnyj bjulleten’ VOZ. 2013.- N 204
3. Perz JF, Armstrong GL, Leigh A, et al. Farrington the contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwid. Journal of Hepatology. 2006; (45): 529–538.
4. Ivashkin VT, German EN, Maevskaja MV. RZhGGK. 2008; 18( 2): 4.
5. Zverev VV. Vakcinacija. Novosti vakcinoprofilaktiki. 2001; 3 (15). [Internet] [cited 2014 Jan 12]. Available at: http://medi.ru/.
6. Baramzina S.V. Khronicheskaya HCV i HBV- infektsiya u detey: dinamika pokazateley zabolevayemosti za 5-letniy period nablyudeniya [Chronic HCV and HBV-infection in children: the dynamics of morbidity over a 5-year follow-up] In: Infektsionnyye bolezni u detey: diagnostika, lecheniye i profilaktika [Infectious diseases in children: diagnosis, treatment and prevention]. StPetersburg; 2012. p.47.
7. Official statistics on infectious diseases in the Kirov region and the Russian Federation for 1994-2012 years. [Internet]. [cited 2014 Jan 12]. Available at: http: //www.43. rospotrebnadzor.ru i http://rospotrebnadzor.ru.
8. Shahgildjan IV, Mihajlov MI, Onishhenko GG .Vakcinoprofilaktika gepatita V v Rossii: proshloe, nastojashhee, budushhee [Vaccine Prevention of hepatitis B in Russia: Past, Present, Future]. In: Virusnyye gepatity: problemy epidemiologii, diagnostiki, lecheniya profilaktiki [Viral hepatitis: problems of epidemiology, diagnosis, treatment, prevention]: Abstracts of VIII All-Russian Conference. Moscow; 2009. р.67. Russian.
9. The epidemiological situation in the Russian Federation in 1998: The State Report. Moscow: Federal’nyj centr gossanjepidnadzora Minzdrava Rossii, 1999. P. 128-132.
10. The measures aimed at the elimination of acute hepatitis B in the Russian Federation: Resolution of Chief State Sanitary Doctor of the Russian Federation, 2012 May 30. [Internet] [cited 2014 Jan 12]. Available at: http://www.rg.ru (data obrashhenija 12.01.2014)
11. Situation with sanitary and epidemiological welfare of the population in the Russian Federation in 2012: The State Report. Moscow: Federal’naja sluzhba po nadzoru v sfere zashhity prav potrebitelej i blagopoluchija cheloveka; 2013. 176 p.
12. Jushhuk ND, Klimova EA, Znojko OO. Rossiyskiy Zhurnal Gastroenterologii, Gepatologii, Koloproktologii. 2010; 20(6):4-60.
13. Hepatitis B: Role of hepatitis B vaccine. [Internet] [cited 2014 Jan 12]. Available at: http: //www.pkids. org/ pedheprep.htm.
14. Esmembetov KI, Abdurahmanov DT, Odincov AV, et al. Rossiyskiy Zhurnal Gastroenterologii, Gepatologii, Koloproktologii. 2013; 23(3): 49-55
15. Jushhuk ND, Znojko OO, Dudina KR. Jushhuk N.D. Zdravoohranenie. 2012; 12: 68-76
Review
For citations:
Baramzina S.V., Bondarenko A.L. Influence of supplementary immunization activities for adults dynamics of chronic disease HBV-infection and its outcomes. Journal Infectology. 2014;6(1):47-53. (In Russ.) https://doi.org/10.22625/2072-6732-2014-6-1-47-53
Views:
574
.png)
.png)
Email this article 