Interleukins as one of possible markers for early diagnosis of viral hepatitis c at first year old children

Abstract

The article presents the results of the research of improvement one of possible methods of early diagnostics of viral hepatitis C at first-year old children, who born from mothers with chronic viral hepatitis C, in blood anti-HCV IgG are revealed, based on the study of maintenance of blood serum interleukins in dynamic observation of children. Proven that for children with maternal antibodies to virus of hepatitis C gradual decrease of titer of anti-HCV IgG is marked on background of physiological maintenance of interleukins or their level doesn’t exceed the normal in 1,5-2 time. For children with own antibodies of anti-HCV IgG a few months prior to viral RNA and synthesis of anti-HCV IgМ in blood is observed increase of level of interleukins, especially ІL-6. At children with their own anti-HCV IgG antibodies for few months before the synthesis of anti-HCV IgM are increased levels of interleukins, particularly IL-6. Thus, the serum interleukins response is an important criterion in determining the conditioning of antibodies to virus hepatitis C and earlier diagnosis of viral hepatitis C for first-year old children. Among all interleukins the most specific early marker of viral hepatitis C is IL-6. To clarify the belonging antibodies and more early diagnostics viral hepatitis С to all first-year old children, who born from mothers with chronic viral hepatitis С, and whose blood had educed antibodies of anti-HCV IgG, it is recommended the more careful monitoring of titer of antibodies of class IgМ, IgG, PCR and level of interleukins in serum (especially ІL- 6).