The comparative description of clinical course, injury an regeneration of liver while chronic HBV- and HCV- infections course
https://doi.org/10.22625/2072-6732-2013-5-1-91-98
Abstract
The comparative test of epidemiological, clinical, morphological and immunomorphological peculiarities of chronic hepatitis and liver cirrhosis, caused by viruses hepatitis B and C, has been made. Social, epidemiological and clinical peculiarities of chronic HCV-infection, which contribute this infection to spread, have been revealed. The specific features of injury and regeneration of liver at different stages of natural course of chronic HBC- and HCV – infections, conditioned by different pathogenesis and underlying in basis of clinical and morphological presentations, have been explored. Various injury levels of hepatocytes at different stages of natural course of chronic HBV- and HCV- infections are conditioned by the peculiarities of the local cell immune reaction. The varied regenerative potential of hepatocytes at different stages of natural course of HBV- and HCV- infections might be high and ensuring the preservation of the liver function while the injury of hepatocytes retains on the stage of chronic hepatitis, and it might be low, resulting in the liver insufficiency progress on the stage of decompensate cirrhosis of liver.
About the Authors
V. E. Karev
Scienсе Research Institute of Children’s Infections FMBA of Russia, Saint-Petersburg
Russian Federation
Russian Federation
Yu. V. Lobzin
Scienсе Research Institute of Children’s Infections FMBA of Russia, Saint-Petersburg
Russian Federation
Russian Federation
V. A. Cinserling
Scienсе Research Institute of Phthisiopulmonology, Saint-Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Karev V.E., Lobzin Yu.V., Cinserling V.A. The comparative description of clinical course, injury an regeneration of liver while chronic HBV- and HCV- infections course. Journal Infectology. 2013;5(1):91-98. (In Russ.) https://doi.org/10.22625/2072-6732-2013-5-1-91-98
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