Bacterial infections in pediatric and adolescent in allogeneic hematopoietic stem cell transplantation recipients: etiology, structure, risk factors
https://doi.org/10.22625/2072-6732-2013-5-1-35-43
Abstract
155 children and adolescents who had been diagnosed oncohematological diseases and had undergone allogeneic hemapoetic stem cell transplantation were examined. In post-transplant period 80% of patients developed different bacterial complications. Main risk factors of bacterial infections were acute leukemia (73%), acute «graft versus host disease» (61%), severe infectious complications before HSCT (30%), cytomegaloviral reactivation (51%). Main causative agents were Kl. pneumoniae (15%), Escherichia coli (8%), Enterobacter sp. (7%), Pseudomonas sp. (6,5%), Enterococcus sp. (16,5%), S.еpidermidis (13,5%). Most frequent involved sites are urinary tract (30,6%), lungs (22,5%) and bacteriemia (38,7%). Rise in ciprofloxacin resistans among Entorobactri, aerobic and Gram-positive cocci. General survival rate of patients with bacterial complications was 36,3% (p<0,001). Number of infectious episodes and their severity were statistically significant (both p<0,001) deteriorating factor for general surviral rate.
About the Authors
M. Yu. Averyanova
Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after academic I.P. Pavlov, Saint-Petersburg
Russian Federation
Russian Federation
V. N. Vavilov
Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after academic I.P. Pavlov, Saint-Petersburg
Russian Federation
Russian Federation
S. N. Bondarenko
Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after academic I.P. Pavlov, Saint-Petersburg
Russian Federation
Russian Federation
O. S. Uspenskaya
Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after academic I.P. Pavlov, Saint-Petersburg
Russian Federation
Russian Federation
N. V. Stancheva
Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after academic I.P. Pavlov, Saint-Petersburg
Russian Federation
Russian Federation
E. V. Semenova
Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after academic I.P. Pavlov, Saint-Petersburg
Russian Federation
Russian Federation
A. G. Volkova
Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after academic I.P. Pavlov, Saint-Petersburg
Russian Federation
Russian Federation
B. I. Smirnov
Saint-Petersburg State Electrotechnical University named after V.I. Ulianov, Saint-Petersburg
Russian Federation
Russian Federation
I. B. Baranova
Saint-Petersburg State Medical University named after academic I.P. Pavlov, Saint-Petersburg
Russian Federation
Russian Federation
L. S. Zubarovskaya
Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after academic I.P. Pavlov, Saint-Petersburg
Russian Federation
Russian Federation
N. N. Klimko
North-Western State Medical University named after I.I. Mechnicov, Saint-Petersburg
Russian Federation
Russian Federation
B. V. Afanasyev
Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after academic I.P. Pavlov, Saint-Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Averyanova M.Yu., Vavilov V.N., Bondarenko S.N., Uspenskaya O.S., Stancheva N.V., Semenova E.V., Volkova A.G., Smirnov B.I., Baranova I.B., Zubarovskaya L.S., Klimko N.N., Afanasyev B.V. Bacterial infections in pediatric and adolescent in allogeneic hematopoietic stem cell transplantation recipients: etiology, structure, risk factors. Journal Infectology. 2013;5(1):35-43. (In Russ.) https://doi.org/10.22625/2072-6732-2013-5-1-35-43
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