Ultrasonic characteristics of immune bodies in children with infectious mononucleosis
https://doi.org/10.22625/2072-6732-2020-12-5-78-84
Abstract
Diagnostic morphometric criteria for splenomegaly in children with infectious mononucleosis are established using ultrasound. The study included 29 children with infectious mononucleosis. The average age is 11.7 ± 3.5 years. A morphometric measurement of the length, width and thickness of the spleen, elastometry (EM), and lymph nodes were evaluated. The spleen mass was determined by method of O.V. Vozgoment, coefficients: the ratio of spleen mass to body mass (KMS, Km), body length (KI), body surface area (Ks). The average CCM value was 6,47 ± 2,8, the absolute value of the indicator varied from 1,9 to 14,2. According to the CCM, patients are divided into 3 groups: group A – 6 (20,7%), group B – 11 (38%), group C – 12 (41,3%). The average mass of the spleen was 332,5 ± 119.6 g, the CMS – from 7,7 to 14,2, the average value of the indicator – 8,6 ± 1,9. In group B the mass of the spleen, compared with group C is 1,2 times less. In group C the spleen mass is statistically significantly greater compared with groups A and B. In group C, spleen rigidity was increased in 42,9% of cases. The average EM value is 15,8 ± 4,8 kPa. A negative correlation between the average strength between EM and age (r = – 0,65, p = 0,01) was revealed. A direct relationship was found between the mass of the spleen and the CMS, and lymphadenopathy of various localization, often periportal lymph nodes.
About the Authors
S. A. Perepelitsa
Baltic Federal University named after Imannuel Kant;
Research Institute of General Reanimatology named after V.A. Negovsky of Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
Russian Federation
Russian Federation
Kaliningrad;
Moscow
L. A. Perminova
Baltic Federal University named after Imannuel Kant
Russian Federation
Kaliningrad
Russian Federation
Kaliningrad
I. A. Stepanyan
Baltic Federal University named after Imannuel Kant;
Infectious Diseases Hospital of Kaliningrad Region
Russian Federation
Kaliningrad
Russian Federation
Kaliningrad
E. V. Zakhar
Infectious Diseases Hospital of Kaliningrad Region
Russian Federation
Kaliningrad
Russian Federation
Kaliningrad
References
1. Fourcade G. Evolution of EBV seroprevalence and primary infection age in a French hospital and a city laboratory network, 2000-2016 / G. Fourcade, R. Germi, F. Guerber, J. Lupo, M. Baccard, A. Seigneurin, T. Semenova, P. Morand, O. Epaulard // PLoS One. –2017. –V. 12. – № 4. – e0175574. doi: 10.1371/journal.pone.0175574. PMID: 28414725. PMCID: PMC5393566.
2. Noor M. Splenic infarct in a patient with Infectious Mononucleosis: a rare presentation. / M. Noor, M. Sadough, S. Chan, G. Singh // J Community Hosp Intern Med Perspect. –2017. – V. 7. – № 4. – Р. 248-250. doi: 10.1080/20009666.2017.1361291. eCollection 2017 Oct. PMID: 29046754. PMCID: PMC5637648.
3. Curovic Rotbain E, Lund Hansen D, Schaffalitzky de Muckadell O, Wibrand F, Meldgaard Lund A, Frederiksen H. Splenomegaly – Diagnostic validity, work-up, and underlying causes. PLoS One. 2017 Nov 14;12 (11):e0186674. doi: 10.1371/ journal.pone.0186674. eCollection 2017. PMID: 29135986 PMCID: PMC5685614.
4. Rostgaard K. Primary Epstein-Barr virus infection with and without infectious mononucleosis./ K. Rostgaard, H.H. Balfour, R. Jarrett, C. Erikstrup, O. Pedersen, H. Ullum, L.P. Nielsen, M. Voldstedlund, H. Hjalgrim // PLoS One. – 2019. – V. 14. – № 12. – e0226436. doi: 10.1371/journal.pone.0226436. eCollection 2019. PMID: 31846480.
5. Farukhi S. N. The role of ultrasound in the management and diagnosis of infectious mononucleosis/ S. N Farukhi, J. C Fox // Crit Ultrasound J. –2014. – V. 6. – № 1. – Р. 4. Published online 2014 Feb 28. doi: 10.1186/2036-7902-6-4.PMCID: PMC3942514.
6. Lennon P. Infectious mononucleosis / P. Lennon, M. Crotty, J.E. Fenton // BMJ. –2015. –№ 350. –h1825. doi: 10.1136/bmj.h1825. PMID: 25899165.
7. Fugl A. Epstein-Barr virus and its association with disease – a review of relevance to general practice / A. Fugl, C.L. Andersen // BMC Fam Pract.–2019. –V. 20. – № 1. – Р. 62. doi: 10.1186/s12875-019-0954-3. PMID: 31088382. PMCID: PMC6518816.
8. Mihneva, S.A. Infekcionnyj mononukleoz: prostranstvenno-vremennoe proyavlenie epidemicheskogo processa / S.A. Mihneva, YU.V. Martynov, E.V. Kuhtevich, YU.YU. Grishina // Epidemilogiya. – 2018.– T. 307. –№ 10. – S. 50-54.
9. Hosey R.G. Ultrasonographic evaluation of splenic enlargement in athletes with acute infectious mononucleosis / R.G. Hosey, V. Kriss, T.L. Uhl, J. DiFiori, S. Hecht, D.Y. Wen // Br J Sports Med. –2008. – V. 42. – № 12. – Р. 974-7. doi: 10.1136/bjsm.2008.050807. PMID: 18801776.
10. Naviglio S. Splenic Infarction in Acute Infectious Mononucleosis / S. Naviglio, M.V. Abate, M. Chinello, A. Ventura // J Emerg Med. –2016. – V. 50. – № 1. – e11-3. doi: 10.1016/j.jemermed.2015.09.019. Epub 2015 Oct 23. PMID: 26602427.
11. Heo D-H. Splenic infarction associated with acute infectious mononucleosis due to Epstein–Barr virus infection / D-H. Heo, D-Y. Baek, O. Sang-Min [et al.] // J Med Virol. – 2017. – № 89. Р. 332–336. PMID: 27357912.
12. Gang M.H. Splenic infarction in a child with primary Epstein–Barr virus infection / M.H. Gang, J.Y. Kim // Pediatr Int. – 2013. – № 55. – e126–e128. PMID: 24134766.
13. Becker J.A. Return to play after infectious mononucleosis / J.A. Becker, J.A. Smith // Sports Health. – 2014. – V. 6. – № 3. – Р. 232-8. doi: 10.1177/1941738114521984. PMID: 24790693. PMCID: PMC4000473.
14. Alaoui C.R.. Spontaneous rupture of the spleen in a child / C.R. Alaoui, M. Rami, K. Khatalla, A. Elmadi, Y. Bouabdellah // Pan Afr Med J. – 2019. – № 32. – Р. 184. doi: 10.11604/pamj.2019.32.184.4260.
15. Pelizzo G. Spleen size evaluation in children: Time to define splenomegaly for pediatric surgeons and pediatricians / G. Pelizzo, M. Guazzotti, C. Klersy, G. Nakib, F. Costanzo, E. Andreatta, G. Bassotti, V. Calcaterra // PLoS One. –2018. – V. 13. – № 8. –e 0202741. doi: 10.1371/journal.pone.0202741. PMID: 30138410. PMCID: PMC6107197.
16. Vozgoment, O.V. Novye podhody k ul’trazvukovoj ocenke razmerov selezenki u detej / O.V. Vozgoment, M.I. Pykov, N.V. Zajceva // Ul’trazv. i funkc. diagnostika. –2013. – № 6. – S. 56-62.
17. Sigrist R.M.S. Ultrasound Elastography: Review of Techniques and Clinical Applications / R.M.S. Sigrist, J. Liau, A. E. Kaffas, M. C. Chammas, J. K. Willmann // Theranostics. – 2017. – V. 7. – № 5. – Р. 1303–1329. doi: 10.7150/thno.18650. PMID: 28435467. PMCID: PMC5399595.
18. Popova, O.A. Kriterii ocenki stepeni tyazhesti infekcionnogo mononukleoza u detej / O.A. Popova, Z.A. Hohlova // Detskie infekcii. –2019. – T. 18. – № 1. –S. 56-59.
19. SHamsheva, O.V. Rezul›taty mnogoletnego izucheniya gerpesvirusnoj infekcii na kafedre infekcionnyh boleznej u detej RNIMU / O. V. SHamsheva, F. S. Harlamova, N.YU. Egorova, O. V. Molochkova, E. V. Novosad, E. V. Simonova, T.M. Lebedeva, N.A. Guseva // Detskie infekcii. – 2017. – V.16. – № 2. – R. 5-12. https://doi.org/10.22627/2072-8107-2017-16- 2-5-12.
20. Dutlova, D.V. Kliniko-laboratornye osobennosti infekcionnogo mononukleoza u detej v zavisimosti ot etiologii zabolevaniya / D.V. Dutlova, O. I. Urazova, A.P. Pomogaeva // Detskie infekcii. –2016. – T.15. – № (1). – S. 30-34. https://doi.org/10.22627/2072-8107-2016-15-1-30-34.
21. Nagovicyna, E.B. Sovremennye podhody k diagnostike i lecheniyu infekcionnogo mononukleoza Epshtejna – Barr- virusnoj etiologii./ Nagovicina E.B.// Dal’nevost. med. zhurnal. -2016. – № 3. – S. 45-50.
Review
For citations:
Perepelitsa S.A., Perminova L.A., Stepanyan I.A., Zakhar E.V. Ultrasonic characteristics of immune bodies in children with infectious mononucleosis. Journal Infectology. 2020;12(5):78-84. (In Russ.) https://doi.org/10.22625/2072-6732-2020-12-5-78-84
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