НАРУШЕНИЕ БАРЬЕРНОЙ ФУНКЦИИ СТЕНКИ КИШКИ И МИКРОБНАЯ ТРАНСЛОКАЦИЯ ПРИ ВИЧ-ИНФЕКЦИИ
https://doi.org/10.22625/2072-6732-2012-4-3-35-41
Аннотация
Транслокация компонентов бактерий, в частности, эндотоксина грам-отрицательных микроорганизмов, через стенку кишки рассматривается как одна из причин гиперактивации иммунной системы при ВИЧ-инфекции с последующим прогрессированием заболевания. В качестве возможных причин повышения проницаемости стенки кишки обсуждаются: массивная гибель кишечных CD4-лимфоцитов, особенно на острой стадии заболевания, cущественное снижение экспрессии белков, обеспечивающих межэпителиальные связи, продолжающаяся репликация вируса и постоянное воспаление стенки кишки, нарушения микробиоценоза кишечника. Приводятся результаты исследований по изучению роли микробной транслокации в прогрессировании ВИЧ-инфекции.
Об авторе
Г. Р. Хасанова
Казанский государственный медицинский университет, Казань
Россия
Россия
доцент кафедры детских инфекций Казанского государственного медицинского университета, к.м.н.; тел. (843)267-80-06
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Рецензия
Для цитирования:
Хасанова Г.Р. НАРУШЕНИЕ БАРЬЕРНОЙ ФУНКЦИИ СТЕНКИ КИШКИ И МИКРОБНАЯ ТРАНСЛОКАЦИЯ ПРИ ВИЧ-ИНФЕКЦИИ. Журнал инфектологии. 2012;4(3):35-41. https://doi.org/10.22625/2072-6732-2012-4-3-35-41
For citation:
Khasanova G.R. Impairment of gut defense barrier and microbial translocation in HIV-infection. Journal Infectology. 2012;4(3):35-41. (In Russ.) https://doi.org/10.22625/2072-6732-2012-4-3-35-41
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