References

jofin

Журнал инфектологии

Journal Infectology

2072-6732

IPO “АIDSSPbR"

10.22625/2072-6732-2012-4-3-35-41

jofin-111

Research Article

Обзоры

Review

НАРУШЕНИЕ БАРЬЕРНОЙ ФУНКЦИИ СТЕНКИ КИШКИ И МИКРОБНАЯ ТРАНСЛОКАЦИЯ ПРИ ВИЧ-ИНФЕКЦИИ

Impairment of gut defense barrier and microbial translocation in HIV-infection

Хасанова

Г. Р.

Khasanova

G. R.

доцент кафедры детских инфекций Казанского государственного медицинского университета, к.м.н.; тел. (843)267-80-06

gulshatra@mail.ru

Казанский государственный медицинский университет, КазаньРоссияKazan State Medical University, KazanRussian Federation

2012

15092014

433541

2014

Хасанова Г.Р.

Khasanova G.R.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.niidi.ru/jofin/article/view/111

Транслокация компонентов бактерий, в частности, эндотоксина грам-отрицательных микроорганизмов, через стенку кишки рассматривается как одна из причин гиперактивации иммунной системы при ВИЧ-инфекции с последующим прогрессированием заболевания. В качестве возможных причин повышения проницаемости стенки кишки обсуждаются: массивная гибель кишечных CD4-лимфоцитов, особенно на острой стадии заболевания, cущественное снижение экспрессии белков, обеспечивающих межэпителиальные связи, продолжающаяся репликация вируса и постоянное воспаление стенки кишки, нарушения микробиоценоза кишечника. Приводятся результаты исследований по изучению роли микробной транслокации в прогрессировании ВИЧ-инфекции.

Translocation of bacterial components, including endotoxin of gram-negative microorganisms, is considered as one of the factors, contributing to hyperactivation of immune system in HIV-infection and progression of the disease. Possible reasons for increased intestinal permeability are discussed: massive loss of intestinal CD4-lymphocytes, especially during acute phase of disease, significant decrease in tight junction protein expression, on-going viral replication and constant inflammation of gut mucosa, altered gut micro ecology. Results of investigations of the role of microbial translocation in progression of HIV-infection are presented.

ВИЧ-инфекциямикробная транслокацияактивация иммунной системыэндотоксин

HIV-infectionmicrobial translocationactivation of immune systemendotoxin

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The authors declare that there are no conflicts of interest present.