НАРУШЕНИЕ БАРЬЕРНОЙ ФУНКЦИИ СТЕНКИ КИШКИ И МИКРОБНАЯ ТРАНСЛОКАЦИЯ ПРИ ВИЧ-ИНФЕКЦИИ


https://doi.org/10.22625/2072-6732-2012-4-3-35-41

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Аннотация

Транслокация компонентов бактерий, в частности, эндотоксина грам-отрицательных микроорганизмов, через стенку кишки рассматривается как одна из причин гиперактивации иммунной системы при ВИЧ-инфекции с последующим прогрессированием заболевания. В качестве возможных причин повышения проницаемости стенки кишки обсуждаются: массивная гибель кишечных CD4-лимфоцитов, особенно на острой стадии заболевания, cущественное снижение экспрессии белков, обеспечивающих межэпителиальные связи, продолжающаяся репликация вируса и постоянное воспаление стенки кишки, нарушения микробиоценоза кишечника. Приводятся результаты исследований по изучению роли микробной транслокации в прогрессировании ВИЧ-инфекции.


Об авторе

Г. Р. Хасанова
Казанский государственный медицинский университет, Казань
Россия

доцент кафедры детских инфекций Казанского государственного медицинского университета, к.м.н.; тел. (843)267-80-06



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Дополнительные файлы

Для цитирования: Хасанова Г.Р. НАРУШЕНИЕ БАРЬЕРНОЙ ФУНКЦИИ СТЕНКИ КИШКИ И МИКРОБНАЯ ТРАНСЛОКАЦИЯ ПРИ ВИЧ-ИНФЕКЦИИ. Журнал инфектологии. 2012;4(3):35-41. https://doi.org/10.22625/2072-6732-2012-4-3-35-41

For citation: Khasanova G.R. Impairment of gut defense barrier and microbial translocation in HIV-infection. Journal Infectology. 2012;4(3):35-41. (In Russ.) https://doi.org/10.22625/2072-6732-2012-4-3-35-41

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