Evidential base for lack of association between preventive vaccination and autism spectrum disorders (Literature review)
https://doi.org/10.22625/2072-6732-2020-12-1-23-34
Abstract
The etiology of autism spectrum disorders still remains unclear. Recently a number of research have emerged linking the increment of vaccination in population and the increased frequency of autism spectrum disorders. In this review we analyzed the most representational studies on this issue. The main hypotheses linking autism spectrum disorders and vaccination were identified: association of vaccination against measles and enteropathy caused by the components of the measles virus vaccine strain which indirectly affects the brain; the onset of autism symptoms as a result of postvaccine encephalitis due to the use of various vaccines: the Measles, Mumps, Rubella vaccine, Diphtheria, Pertussis, Tetanus vaccine; the effect of multivaccine on the development of autism spectrum disorders; the effect of individual components of vaccines, particularly thimerosal, on the development of childhood autism and similar conditions. The data of epidemiological studies that refute these hypotheses were presented. Large samples in these studies provide a level of statistical significance sufficient enough to reveal even rare statistical associations. These results actually disproved the notion that vaccines cause autism.
About the Authors
S. V. Grechanyy
Saint-Petersburg State Pediatric Medical University
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
V. V. Pozdnyak
Saint-Petersburg State Pediatric Medical University
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
Yu. V. Khutoryanskaya
Saint-Petersburg State Pediatric Medical University
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
О. S. Kul’bakh
Saint-Petersburg State Pediatric Medical University
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
G. О. Bagaturiya
Saint-Petersburg State Pediatric Medical University
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
References
1. American Psychiatric Association (2013). “Autism Spectrum Disorder. 299.00 (F84.0)”. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Arlington, VA: American Psychiatric Publishing. pp. 50–59. doi:10.1176/appi. books.9780890425596. ISBN 978-0-89042-559-6.
2. Mercer L./ Mercer L., Creighton S., Holden J.J., Lewis M.E.// Parental perspectives on the causes of an autism spectrum disorder in their children. J Genet Couns. 2006;15(1):4150.
3. Harrington J.W./ Harrington J.W., Rosen L., Garnecho A., Patrick P.A. // Parental perceptions and use of complementary and alternative medicine practices for children with autistic spectrum disorders in private practice. J Devehav Pediatr. 2006;27(2) (suppl): S156-S161.
4. Gastañaduy P.A./ Gastañaduy P.A., Redd S.B., Fiebelkorn A.P., et al.// Division of Viral Disease, National Center for Immunization and Respiratory Diseases, CDC. Measles—United States, January 1-May 23, 2014. MMWR Morb Mortal Wkly Rep. 2014;63(22):496-499.
5. V. N. Timchenko/ V. N. Timchenko, T. A. Kaplina, O.V. Bulina, O. A. Leonicheva, Zh.K. Xakizimana, E. V. Timofeeva// Aktual`ny`e problemy` korevoj infekcii, Zhurnal Pediatr 2017, tom 8, vy`pusk 3 str.120-129.
6. Wing L./ Wing L., Gould J.// Severe impairments of social interaction and associated abnormalities in children: epidemiology and classification. J Autism Dev Dis-ord. 1979;9(1):1129.
7. Fombonne E.// Epidemiology of pervasive developmental disorders. Pediatr Res. 2009;65(6):591-598.
8. Brugha T.S./ Brugha T.S., McManus S., Bankart J., et al. // Epidemiology of autism spectrum disorders in adults in the community in England. Arch Gen Psychiatry. 2011;68(5): 459– 465.
9. Y. S. Kim/ Y. S. Kim, B. L. Leventhal, Y.-J. Koh et al.//, Prevalence of autism spectrum disorders in a total population sample, American Journal of Psychiatry, vol. 168, no. 9, pp. 904–912, 2011.
10. Dales L./ Dales L., Hammer S. J., Smith N.J.// Time trends in autism and in MMR immunization coverage in California. JAMA. 2001 Mar 7;285(9):1183-5.
11. Gust D.A./ Gust D.A., Strine T.W., Maurice E., et al.// Underimmunization among children: effects of vaccine safety concerns on immunization status. Pediatrics. 2004;114(1): e16-e22.
12. Zerbo O./ Zerbo O., Modaressi S., Goddard K., et al.// Vaccination Patterns in Children After Autism Spectrum Disorder Diagnosis and in Their Younger Siblings. JAMA Pediatr. 2018 May 1;172(5):469-475. doi: 10.1001/jamapediatrics.2018.0082.
13. Wakefield A.J./ Wakefield A.J., Murch S.H., Anthony A., et al.// Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children, Lancet, 1998, vol. 351 (pg.637-41).
14. Godlee F./ Godlee F., Smith J., Marcovitch H.// “Wakefield’s article linking MMR vaccine and autism was fraudulent”. BMJ. 342: c7452. January 2011. doi:10.1136/bmj.c7452. PMID 21209060.
15. Bonhoeffer J./ Bonhoeffer J., Heininger U.// Adverse events following immunization: perception and evidence” Current Opinion in Infectious Diseases. 20 (3): 237–46. June 2007. doi:10.1097/QCO.0b013e32811ebfb0.
16. Bustin/ Bustin, Stephen A.// Why There is no Link Between Measles Virus and Autism. Recent Advances in Autism Spectrum Disorders – Volume I., 2013-03-06. doi:10.5772/52844. ISBN 978-953-51-1021-7.
17. Chen R.T./ Chen R.T., DeStefano F. // Vaccine adverse events: causal or coincidental?, Lancet, 1998, vol. 351(pg. 6112).
18. Hornig M./ Hornig M., Briese T., Buie T., et al. // Lack of association between measles virus vaccine and autism with enteropathy: a case-control study, PLoS ONE , 2008, vol. 3 pg. E3140.
19. Flaherty D.K.//”The vaccine-autism connection: a public health crisis caused by unethical medical practices and fraudulent science”. The Annals of Pharmacotherapy. 45 (10): 1302– 4. October 2011. doi:10.1345/aph.1Q318. PMID 21917556.
20. Fombonne E./ Fombonne E., Chakrabarti S. // No evidence for a new variant of measles-mumps-rubella-induced autism. Pediatrics. 2001 Oct;108(4).
21. Taylor B./ Taylor B., Miller E., Lingam R., Andrews N., Simmons A., Stowe J. // Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population study. BMJ. 2002 Feb 16;324(7334):393-6.
22. Miller E.// Measles-mumps-rubella vaccine and the development of autism. Semin Pediatr Infect Dis. 2003 Jul;14(3):199-206.
23. Halsey N.A./ Halsey N.A., Hyman S.L.// Measlesmumps-rubella vaccine and autistic spectrum disorder: report from the New Challenges in Childhood Immunizations Conference convened in Oak Brook, Illinois, June 12-13, 2000. Pediatrics. 2001 May;107(5): E84.
24. Extract from report of GACVS meeting of 16-17 December 2002, published in the WHO Weekly Epidemiological Record on 24 January 2003. MMR and autism // https://www. who.int/vaccine_safety/committee/topics/mmr/Dec_2002/ en/
25. Patja A./ Patja A., Davidkin I., Kurki T., Kallio M.J., Valle M., Peltola H.// Serious adverse events after measles-mumpsrubella vaccination during a fourteen-year prospective followup, Pediatr Infect Dis J, 2000, vol. 19 (pg. 1127-3).
26. Wilson K./ Wilson K., Mills E., Ross C., McGowan J., Jadad A.// Association of autistic spectrum disorder and the measles, mumps, and rubella vaccine: a systematic review of current epidemiological evidence. Arch Pediatr Adolesc Med. 2003 Jul;157(7):628-34.
27. Taylor B./ Taylor B., Miller E., Farrington C.P., et al.// Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association, Lancet, 1999, vol. 353 (pg. 2026-9).
28. Fombonne E./ Fombonne E., Zakarian R., Bennett A., Meng L., McLean-Heywood D.// Pervasive developmental disorders in Montreal, Quebec, Canada: prevalence and links with immunizations, Pediatrics, 2006, vol. 118 (pg. e139-50).
29. DeWilde S./ DeWilde S., Carey I.M., Richards N., Hilton S.R., Cook D.G. // Do children who become autistic consult more often after MMR vaccination?, Br J Gen Pract , 2001, vol. 51 (pg. 226-72).
30. Demicheli V./ Demicheli V., Rivetti A., Debalini M.G., Di Pietrantonj C. // Vaccines for measles, mumps and rubella in children. Cochrane Database Syst Rev. 2012;2:CD004407.
31. DeStefano F./ DeStefano F., Bhasin T.K., Thompson W.W., Yeargin-Allsopp M., Boyle C.// Age at first measlesmumps-rubella vaccination in children with autism and schoolmatched control subjects: a population-based study in metropolitan Atlanta, Pediatrics, 2004, vol. 113 (pg. 259-66).
32. Hideo Honda/Hideo Honda , Yasuo Shimizu, Michael Rutter//No effect of MMR withdrawal on the incidence of autism: a total population study. Journal of Child Psychology and Psychiatry 46:6 (2005), pp 572–579.
33. Glickman G./ Glickman G., Harrison E., Dobkins K.// Vaccination rates among younger siblings of children with autism. N Engl J Med. 2017;377(11):1099-1101.
34. Kreesten Meldgaard Madsen/ Kreesten Meldgaard Madsen, M.D., Anders Hviid, M.Sc., Mogens Vestergaard, M.D., Diana Schendel, Ph.D., Jan Wohlfahrt, M.Sc., Poul Thorsen, M.D., Jεrn Olsen, M.D., and Mads Melbye, M.D.// A Population-Based Study of Measles, Mumps, and Rubella Vaccination and Autism. N Engl J Med 2002; 347:1477-1482.
35. Jain A./ Jain A., Marshall J., Buikema A., Bancroft T., Kelly J.P., Newschaffer C.J. //Autism occurrence by MMR vaccine status among US children with older siblings with and without autism. JAMA. 2015 Apr 21;313(15):1534-40. doi: 10.1001/jama.2015.3077.
36. Becerra-Culqui T.A./ Becerra-Culqui T.A., Getahun D., Chiu V., Sy L.S., Tseng H.F.// Prenatal Tetanus, Diphtheria, Acellular Pertussis Vaccination and Autism Spectrum Disorder. Pediatrics. 2018 Sep;142(3). pii: e20180120. doi: 10.1542/ peds.2018-0120. Epub 2018 Aug 13.
37. Uno Y./Uno Y., Uchiyama T., Kurosawa M., Aleksic B., Ozaki N.// The combined measles, mumps, and rubella vaccines and the total number of vaccines are not associated with development of autism spectrum disorder: the first casecontrol study in Asia. Vaccine. 2012 Jun 13;30(28):4292-8. doi: 10.1016/j.vaccine.2012.01.093. Epub 2012 Apr 20.
38. Hilton S./ Hilton S., Petticrew M., Hunt K.// Combined vaccines are like a sudden onslaught to the body’s immune system’: parental concerns about vaccine ‘overload’ and ‘immune-vulnerability’. Vaccine. May 2006. 24 (20): 4321–7. doi:10.1016/j.vaccine.2006.03.003. PMID 16581162.
39. Heron J./ Heron J., Golding J.// Thimerosal exposure in infants and developmental disorders: a prospective cohort study in the United Kingdom does not support a causal association, Pediatrics, 2004, vol. 114 (pg. 577-83).
40. Andrews N./ Andrews N., Miller E., Grant A., Stowe J., Osborne V., Taylor B. // Thimerosal exposure in infants and developmental disorders: a retrospective cohort study in the United Kingdom does not support a causal association, Pediatrics , 2004, vol. 114 (pg. 584-91)47.
41. Offit P.A./ Offit P.A., Quarles J., Gerber M.A., et al. // Addressing parents’ concerns: do multiple vaccines overwhelm or weaken the infant’s immune system? Pediatrics, 2002, vol. 109 (pg. 124-9).
42. Gerber J.S./ Gerber J.S., Offit P.A. // Vaccines and autism: a tale of shifting hypotheses”. Clinical Infectious Diseases. February 2009. 48 (4): 456–61. doi:10.1086/596476. PMC 2908388. PMID 19128068. Lay summary – IDSA (200901-30).
43. Laupland K.B./ Laupland K.B., Davies H.D., Low D.E., Schwartz B., Green K., McGeer A. // Invasive group A streptococcal disease in children and association with varicella-zoster virus infection. Ontario Group A Streptococcal Study Group, Pediatrics, 2000, vol. 105 pg. E60.
44. Takahashi H./ Takahashi H., Suzumura S., Shirakizawa F., Wada N., Tanaka-Taya K., Arai S., Okabe N., Ichikawa H., Sato T.// An epidemiological study on Japanese autism concerning routine childhood immunization history. Jpn J Infect Dis. 2003 Jun;56(3):114-7.
45. Mrozek-Budzyn D./ Mrozek-Budzyn D., Kiełtyka A., Majewska R.// Lack of association between measles-mumps rubella vaccination and autism in children: a case-control study. Pediatr Infect Dis J. 2010 May;29(5):397-400.
46. Baker J.P.// Mercury, vaccines, and autism: one controversy, three histories. American Journal of Public Health. February 2008. 98 (2): 244–53. doi:10.2105/AJPH.2007.113159. PMC 2376879. PMID 18172138.
47. Offit P. A. //Thimerosal and vaccines--a cautionary tale. The New England Journal of Medicine. September 2007. 357 (13): 1278–9. doi:10.1056/NEJMp078187. PMID 17898096. 48. Centers for Disease Control Prevention. Thimerosal in vaccines: a joint statement of the American Academy of Pediatrics and the Public Health Service, MMWR Morb Mortal Wkly Rep, 1999, vol. 48 (pg. 563-5).
48. Verstraeten T./ Verstraeten T., Davis R.L., DeStefano F., et al.// Safety of thimerosal-containing vaccines: a two-phased study of computerized health maintenance organization databases, Pediatrics, 2003, vol. 112 (pg. 1039-48).
49. Anders Hviid/ Anders Hviid, Michael Stellfeld, Jan Wohlfahrt, et al. //Association Between Thimerosal-Containing Vaccine and Autism JAMA. 2003; 290(13):1763-1766 (doi:10.1001/jama.290.13.1763).
50. Stehr-Green P./ Stehr-Green P., Tull P., Stellfeld M., Mortenson P.B., Simpson D.// Autism and thimerosal-containing vaccines: lack of consistent evidence for an association, Am J Prev Med , 2003, vol. 25 (pg. 101-6)
51. Nelson K.B./ Nelson K.B., Bauman M.L.// Thimerosal and autism? Pediatrics , 2003, vol. 111 (pg. 674-9).
52. Centers for Disease Control and Prevention. Frequently Asked Questions about Thimerosal”. www.cdc.gov. Retrieved 21 February 2014.
53. Lidsky T.I. //”Is the Aluminum Hypothesis dead?”. Journal of Occupational and Environmental Medicine. May 2014. 56 (5 Suppl): S73–9. doi:10.1097/JOM.0000000000000063. PMC 4131942. PMID 24806729.
54. Karwowski M.P., Stamoulis C., Wenren L.M., Faboyede G.M., Quinn N., Gura K.M., Bellinger D.C., Woolf A.D.// «Blood and Hair Aluminum Levels, Vaccine History, and Early Infant Development: A Cross-Sectional Study». Academic Pediatrics. 18 (2): 161–165. March 2018. doi:10.1016/j. acap.2017.09.003.PMID 28919482.
55. Czunami destkogo autizma: medicinskaya i psixologopedagogicheskaya pomoshh`. Pod red. A. P. Chuprikova. – M.: Gnozis, 2017. – S. 113
56. Pearson N./ Pearson N., Charman T., Happε F., Bolton P.F., McEwen F.S.// Regression in autism spectrum disorder: Reconciling findings from retrospective and prospective research. Autism Res. 2018 Dec;11(12):1602-1620. doi: 10.1002/ aur.2035.
57. Grechanyy S. V.// Problemy` i zadachi psixopatologicheskogo metoda v diagnostike psixicheskix rasstrojstv rannego detskogo vozrasta. Voprosy` psixicheskogo zdorov`ya detej i podrostkov. Nauchno-prakticheskij recenziruemy`j zhurnal psixiatrii, psixologii, psixoterapii i smezhny`x disciplin. 2018 (18). – № 1. – S. 12-19.
58. Grechanyy S. V.// Kliniko-e`tologicheskie aspekty` rechevogo razvitiya rebenka / Grechanyy S. V. // Klinicheskaya psixoterapiya (instinktivno-povedencheskie i nejropsixologicheskie modeli) / Pod. Red. Yu. S. Shevchenko. M.: OOO «Izdatel`stvo «Medicinskoe informacionnoe agenstvo», 2018. – S. 76-116.
59. Grechanyy S. V.// Psixopatologicheskaya diagnostika v rannem detskom vozraste. Uchebnoe posobie dlya poslediplomnogo obrazovaniya. SPb: SPbGPMU, 2017. – 96 s.
Review
For citations:
Grechanyy S.V., Pozdnyak V.V., Khutoryanskaya Yu.V., Kul’bakh О.S., Bagaturiya G.О. Evidential base for lack of association between preventive vaccination and autism spectrum disorders (Literature review). Journal Infectology. 2020;12(1):23-34. (In Russ.) https://doi.org/10.22625/2072-6732-2020-12-1-23-34
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