jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2020-12-1-23-34jofin-1009Research ArticleОбзорыReviewДоказательная база отсутствия связи между профилактическими прививками и расстройствами аутистического спектра (обзор литературы)Evidential base for lack of association between preventive vaccination and autism spectrum disorders (Literature review)ГречаныйС. В.GrechanyyS. V.

Гречаный Северин Вячеславович – заведующей кафедрой психиатрии и наркологии, д.м.н., доцент.

Санкт-Петербург, тел.: 8(812)295-06-46,  +7-921-887-59-91

Saint-Petersburg

svgrechany@mail.ruПозднякВ. В.PozdnyakV. V.

Поздняк Вера Владимировна – доцент кафедры психиатрии и наркологии, к.м.н.

Санкт-Петербург, тел.: 8(812)295-06-46,  +7-911-906-32-37

Saint-Petersburg

egodoe@yandex.ruХуторянскаяЮ. В.KhutoryanskayaYu. V.

Хуторянская Юлия Валерьевна – ассистент кафедры психиатрии и наркологии.

Санкт-Петербург, тел.: 8(812)295-06-46, +7-904-616-44-49

Saint-Petersburg

julia.khutoryanskaya@gmail.comКульбахО. С.Kul’bakhО. S.

Кульбах Ольга Станиславовна – профессор кафедры общей и прикладной психологии с курсами  медико-биологических дисциплин и педагогики, д.м.н.

Санкт-Петербург, тел.: 8(812)295-06-46, +7-911-849-49-87

Saint-Petersburg

os_koulbakh@mail.ruБагатурияГ. О.BagaturiyaG. О.

Багатурия Георгий Отарович – доцент, заведующий кафедрой оперативной хирургии и топографической анатомии, д.м.н.

Санкт-Петербург, тел.: 8(812)295-06-46, +7-911-920-40-51

Saint-Petersburg

geobag@mail.ruСанкт-Петербургский государственный педиатрический медицинский университетРоссияSaint-Petersburg State Pediatric Medical UniversityRussian Federation2020190320201212334Copyright © Гречаный С.В., Поздняк В.В., Хуторянская Ю.В., Кульбах О.С., Багатурия Г.О., 20202020Гречаный С.В., Поздняк В.В., Хуторянская Ю.В., Кульбах О.С., Багатурия Г.О.Grechanyy S.V., Pozdnyak V.V., Khutoryanskaya Y.V., Kul’bakh О.S., Bagaturiya G.О.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/1009

Расстройства аутистического спектра — это группа патологических состояний, с неясной этиологией. В последнее время появился ряд работ, связывающих рост вакцинирования с увеличением аутистических расстройств. В обзоре проанализированы наиболее репрезентативные работы, посвященные данной проблеме. Выделены основные гипотезы, связывающие аутизм и вакцинацию: связь противокоревой вакцинации с энтеропатией, вызванной компонентами вакцинального вируса кори, опосредованно влияющей на головной мозг; возникновение симптомов аутизма в связи с поствакцинальным энцефалитом вследствие применения различных вакцин «Корь-краснуха-паротит», «Коклюшдифтерия-столбняк»; влияние поливакцинации на развитие расстройств аутистического спектра; влияние отдельных компонентов профилактических прививок, в частности тимеросала, на развитие детского аутизма и сходных состояний. Представлены данные эпидемиологических исследований, которые опровергают данные гипотезы. Большая выборка популяций обеспечивает уровень статистической достоверности, достаточный для выявления даже редких взаимосвязей. Данные результаты фактически опровергли мнение о том, что вакцины вызывают аутизм.

The etiology of autism spectrum disorders still remains unclear. Recently a number of research have emerged linking the increment of vaccination in population and the increased frequency of autism spectrum disorders. In this review we analyzed the most representational studies on this issue. The main hypotheses linking autism spectrum disorders and vaccination were identified: association of vaccination against measles and enteropathy caused by the components of the measles virus vaccine strain which indirectly affects the brain; the onset of autism symptoms as a result of postvaccine encephalitis due to the use of various vaccines: the Measles, Mumps, Rubella vaccine, Diphtheria, Pertussis, Tetanus vaccine; the effect of multivaccine on the development of autism spectrum disorders; the effect of individual components of vaccines, particularly thimerosal, on the development of childhood autism and similar conditions. The data of epidemiological studies that refute these hypotheses were presented. Large samples in these studies provide a level of statistical significance sufficient enough to reveal even rare statistical associations. These results actually disproved the notion that vaccines cause autism.

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The authors declare that there are no conflicts of interest present.