Cytomegalovirus infection in patients after orthotopic liver transplantation (clinical report)

Herpes viruses are widespread in the human population, they are able to infect almost all organs and systems of the body. Currently, 8 serotypes of herpesviruses pathogenic for humans are known: herpes simplex viruses of the 1st and 2nd. type, chickenpox — herpes zoster, cytomegalovirus, Epstein-Barr virus, 6th, 7th and 8th human herpes viruses. Primary infection with herpes viruses in 60—90% of cases occurs in early childhood, and, as a rule, is not accompanied, by typical clinical manifestations. Due to the lack of mandatory registration of the incidence of herpes virus infections in our country, the true number of patients is unknown. It is believed that about 20 million people are infected, every year in Russia and. the CIS countries. Herpes viruses, to a greater or lesser extent, can be considered, hepatotropic. A large number of studies are devoted, to the problem, of cytomegalovirus infection, one of the manifestations of which, is hepatitis. Most often, cytomegalovirus hepatitis occurs in immunocompromised. individuals or in patients receiving immunosuppressive therapy, cases of cytomegalovirus hepatitis and in immunocompetent individuals are also described. With liver transplantation without antiviral therapy, cytomegalovirus infection manifests itself in 11-28,5% of recipients and. can lead, to the development of liver failure, loss of transplant and. death, of the recipient. Performing diagnostic studies using both, serological and. molecular biological methods at different periods after liver transplantation, allows to detect cytomegalovirus infection timely and. initiate treatment, thereby avoiding graft rejection and. the death, of the recipient.

1. Isakov, V. A. Human herpesvirus infections: a guide for doctors / V. A. Isakov, E. I. Arhipova, D. V. Isakov. - SPb.: Spe-cLit, 2006. - 303 p (in Russian).

2. Infectious Disease Guide / Lobzin Ju. V. - SPb.: Foliant, 2011. - 744 p (in Russian).

3. Kozhevina G. I. Zhurnal infektologii. 2010; 2(3): 100-101 (in Russian).

4. Egorova N. Ju. Pediatrija. Prilozhenie Consillium medicum. 2010; 4: 73-79 (in Russian).

5. Aarnisalo J., Ilonen J., Vainionpaa R., Kaitosaari T., Simell O. Development of antibodies against cytomegalovirus, varicella-zoster virus and herpes simplex virus in Finland during the first eight years of life: a prospective study. Scandinavian Journal of Infectious Diseases. 2003 Jun; 35(10): 750-753.

6. Arvin A., Campadelli-Fiume G., Mocarski E., Moore P., Roizman B., Whitley R., Yamanishi K.. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis: Cambridge University Press; с 2007. 1408 р.

7. Herpesvirus infection / A. K. Polukchi [i dr.]. - Moscow: Exmo, 2009. - 304 p (in Russian).

8. Brennan D. C. et al. Control of cytomegalovirus-associated morbidity in renal transplant patients using intensive monitoring and either preemptive or deferred therapy. Journal of the American Society of Nephrology. 1997 Jan; 8(1): 118-125.

9. Uchajkin V. F. Pediatrija. Zhurnal im. G. N. Speranskogo. 2012; 91(3): 136-142 (in Russian).

10. Smirnov A. V. Children's infections. 2008; 7(1): 18-23 (in Russian).

11. Bruminhent J., Razonable R. R. Management of cytomegalovirus infection and disease in liver transplant recipients. World Journal of Hepatology. 2014 Jun; 6(6): 370-383.

12. Prokopenko E. I. Nephrology and dialysis. 2003; 5(2): 108-116 (in Russian).

13. Barkholt L. M., Johansson B., Veress J., Andersson J. P., Ehrnst A. Polymerase chain reaction for the early diagnosis of cytomegalovirus hepatitis in liver transplant patients. Clinical and Diagnostic Virology. 1995 Aug; 4(2): 121-134.

14. Razonable R. R., Emery V. C. Management of CMV infection and disease in transplant patients. Herpes: The Journal of the IHMF. 2004 Feb; 11(3): 77-86.

15. Razonable R. R., Paya C. V. Herpesvirus infections in transplant recipients: current challenges in the clinical management of cytomegalovirus and Epstein-Barr virus infections. Herpes: The Journal of the IHMF. 2003 Dec; 10(3): 60-65.

16. Chou S. W. Reactivation and recombination of multiple cytomegalovirus strains from individual organ donors. The Journal of infectious diseases. 1989 Jul; 160 (1): 5-11.

17. Sia I. G., Patel R. New strategies for prevention and therapy of cytomegalovirus infection and disease in solid-organ transplant recipients. Clinical Microbiology Reviews. 2000 Jan; 13(1): 83-121.