Predict of the development of lipid distress syndrome in patients with a sustained response to antiviral therapy of chronic hepatitis C

The aim. is to develop a method, for predicting the development of lipid, distress syndrome in patients with a sustained, response to antiviral therapy of chronic viral hepatitis C on the basis of clinical and laboratory data.

Materials and. methods. The outcomes of lipid, distress syndrome were studied in 235 patients with a sustained vi-rological response to antiviral therapy of chronic hepatitis C during the follow-up period, from 1 to 10 years.

Results. On the basis of discriminant analysis of the data of complex examination of 135 patients, a discriminant model of predicting the development of lipid distress syndrome in patients with a sustained response to antiviral therapy of chronic hepatitis C. On the basis of the data of the survey of other 100 patients, cross-checking the accuracy of the prediction. was carried out.

Conclusion. Developed, diskriminantnaja model allows by identifying 5 of biochemical and. immunological parameters of blood (low-density lipoproteins cholesterol, homocysteine, interleukin. 4 and. 10, TNF) to predict the development of lipid distress syndrome in patients with sustained response to antiviral therapy for chronic hepatitis С. The sensitivity, specificity, predictive value of positive and. negative results of forecasting and precision index developed forecasting model of Fisher discriminant lipid, distress syndrome equal 100%. The proposed, method, should, be used, in clinical practice to predict development of lipid, distress syndrome in patients with sustained, response to antiviral therapy for chronic hepatitis C.

1. Gurnitskaya MV. Sostoyanie lipidnogo obmena pri khronicheskikh zabolevaniyakh pecheni. Diss. Stavropol, 2006. (In Russian).

2. Konstantinov DYu, Popova LL, Golik OO. Khronicheskii virusnyi gepatit C i sostoyanie gepatobiliar-noi sistemy: monografiya. Samara: "Vektor" Publ., 2018, 246 p. (In Russian).

3. Tkachenko L.I., Maleev V.V., Sarieva D.M. Narushenie lipidnogo obmena u bol'nyh hronicheskim gepatitom S. Arhiv vnutrennej mediciny. 2015;6(26):50-6. (In Russian).

4. Savel'ev VS, Petukhov VA. Lipidnyi distress-sindrom. Moscow: «MAKS Press» Publ.,2010, 657 p. (In Russian).

5. Konstantinov D.Ju., Nedugov G.V., Suzdal>cev A.A., Konstantinova E.A. Progno-zirovanie razvitija lipidnogo distress-sindroma pri hronicheskom virusnom ge-patite S. Infekcionnye bolezni. 2018; 16(4): 34-37. (In Russian).