HOMOLOGY BETWEEN SEGMENTS OF HUMAN HEMOSTATIC PROTEINS AND PROTEINS OF VIRUSES WHICH CAUSE ACUTE RESPIRATORY INFECTIONS OR DISEASES WITH SIMILAR SYMPTOMS
https://doi.org/10.22625/2072-6732-2017-9-3-81-91
Abstract
Objectives: To identify homologous segments of human hemostatic and viral proteins and to assess the role of human hemostatic proteins in viral replication.
Materials and Methods: The following viruses were chosen for comparison: influenza B (B/Astrakhan/2/2017), coronaviruses (Hcov229E and SARS-Co), type 1 adenovirus (adenoid 71), measles (ICHINOSE-BA) and rubella (Therien). The primary structures of viral proteins and 41 human hemostatic proteins were obtained from open–access www.ncbi.nlm.nih. gov and www.nextprot.org databases, respectively. Sequence homology was determined by comparing 12-amino-acid segments. Those sequences identical in ≥ 8 positions were considered homologous.
Results: The analysis shows that viral proteins contain segments which mimic a number of human hemostatic proteins. Most of these segments, except those of adenovirus proteins, are homologous with coagulation factors. The increase in viral virulence, as in case of SARS-Co, correlates with an increased number of segments homologous with hemostatic proteins.
Conclusion: Hemostasis plays an important role in viral replication and pathogenesis. The conclusion is consistent with the literature data about the relationship of hemostasis and inflammatory response to viral infections.
About the Authors
I. N. Zhilinskaya
Science Research Institute of Unfluenza
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
A. R. Prochukhanova
Science Research Institute of Unfluenza
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
A. V. Fadeev
Science Research Institute of Unfluenza
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
E. P. Kharchenko
Institute of Evolutionary Physiology and Biochemistry named after I.M. Sechenov
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
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Review
For citations:
Zhilinskaya I.N., Prochukhanova A.R., Fadeev A.V., Kharchenko E.P. HOMOLOGY BETWEEN SEGMENTS OF HUMAN HEMOSTATIC PROTEINS AND PROTEINS OF VIRUSES WHICH CAUSE ACUTE RESPIRATORY INFECTIONS OR DISEASES WITH SIMILAR SYMPTOMS. Journal Infectology. 2017;9(3):81-91. (In Russ.) https://doi.org/10.22625/2072-6732-2017-9-3-81-91
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