INFECTIOUS MONONUCLEOSIS AT CHILDREN: FEATURES OF THE COURSE OF THE DISEASE DEPENDING ON TYPES OF ANTIVIRAL THERAPY
https://doi.org/10.22625/2072-6732-2017-9-3-67-74
Abstract
Purpose: The article contains results of the comparative analysis of dynamics of immunological parameters in the clinical period at children with an infectious mononucleosis of moderate severity during the acute period at treatment by the drugs “Anaferon kids “ and “Viferon” and further, in a catamnesis, within 6 years. The materials and methods: In group of research was 187 children. Three groups were created: the I group (n=75) – the patients receiving during the acute period «Anaferon kids» and pathogenetic therapy, the II group (n=72) – «Viferon» and pathogenetic therapy, the III group (n=40) – only with pathogenetic therapy. Results: Against the background of therapy with «Anaferon kids» and «Viferon» normalization of clinical symptoms and laboratory indicators came quicker in comparison with group of the children receiving only symptomatic therapy. At observation in a catamnesis, at all children the high rate of recurrent respiratory diseases was noted by viral infections. Changes in immunologic indicators became perceptible in all three groups throughout the entire period of observation.
About the Authors
Z. A. Khokhlova
Novokuznetsk State Institute for Further Training of Physicians – Branch Campus of Russian Medical Academy of Continuous Professional Education
Russian Federation
Novokuznetsk
Russian Federation
Novokuznetsk
O. A. Popova
Gazprom Transgaz Tomsk LTdGazprom Transgaz Tomsk LTd, medical health center «Kedrovyj» LPUMG
Russian Federation
Russian Federation
Tomsk
Medical health center «Kedrovyj» LPUMG
K. I. Chujkova
Siberian State Medical University
Russian Federation
Tomsk
Russian Federation
Tomsk
V. L. Yakimov
Siberian State Medical University
Russian Federation
Tomsk
Russian Federation
Tomsk
Yu. V. Minakova
Siberian State Medical University
Russian Federation
Tomsk
Russian Federation
Tomsk
E. I. Petrova
Siberian State Medical University
Russian Federation
Tomsk
Russian Federation
Tomsk
References
1. Kramarev S.A. Gerpesvirusnye infektsii u detey // Medicus Amicus. – 2003. – № 4. – S. 8-9.:http://www.medicusamicus.com
2. Blokhina E.B. Rol latentnoy infektsii, vyzvannoy virusom Epshteyna – Barr, v razvitii limfoproliferativnykh zabolevaniy // Voprosy gematologii, onkologii i immunopatologii v pediatrii. – 2003. – T. 2, № 3. – S. 65-70.
3. Zheleznikova G.F. Apoptoz i immunnyy otvet u detey s ostrym infektsionnym mononukleozom / Zheleznyakova G.F., Vasyakina L.I., Monakhova N.E i dr. // Immunopatologiya, allergologiya, infektologiya. – 2000. – № 4. – S. 87-94.
4. Urazova O.I. Subpopulyatsionnyy sostav i metabolizm leykotsitov pri infektsionnom mononukleoze u detey/ Urazova O.I. i dr. // Infektsionnye bolezni. – 2004. – № 4. – S. 17-21.
5. Cohen J.I. Epstein – Barr virus infection. N. Engl. J. Med. 2000Aug; 343(7):481-92.
6. Neuhierl B., Feederle R., Hammerschmidt W., Delecluse H.J. Glycoprotein gp110 of Epstein – Barr virus determines viral tropism and efficiency of infection. Proc. Natl. Acad. Sci USА. 2002 Nov 12; 99(23):15036-41.
7. Leenman E.E. O roli virusa Epshteyna – Barr v patogeneze limfogranulematoza. Immunogistokhimicheskoe i molekulyarnobiologicheskoe (gibridizatsiya in situ) issledovanie / Leenman E.E., Afanas’ev B.V., Pozharisskiy K.M., Denisenko B.B. // Immunopatologiya, allergologiya, infektologiya. – 2003. – № 3. – S. 61-64.
8. Simovan’yan E.N. Khronicheskaya Epshteyna – Barr virusnaya infektsiya u detey/ Simovan’yan E.N., Sizyakina L.P., Sarychev A.M. // Doktor.Ru. – 2006. – № 2. – S. 34-42.
9. Gileva R.A. Kliniko – laboratornaya kharakteristika infektsionnogo mononukleoza, obuslovlennogo virusom Epshteyna – Barr / Gileva R.A., Khokhlova Z. A., Chechet Yu.S., Arsenenko A.S. i dr. // Kazanskiy meditsinskiy zhurnal. – 2014 –T.95. – №5. – S.722-725.
10. Khokhlova Z. A. Kompleksnaya otsenka spetsificheskogo immunnogo otveta k virusu Epshteyna – Barr pri infektsionnom mononukleoze / Khokhlova Z. A., Gileva R. A., Sereda T. V., Nikolaeva N. A. // Rossiyskiy immunologicheskiy zhurnal. – 2016 – T.10, № 4 – S. 505 – 507.
11. Chuykova K.I. Sovershenstvovanie terapii infektsionnogo mononukleoza u detey / Chuykova K.I., Popova O.A. // Detskie infektsii. – 2012. – T. 11, № 4. – S. 48-51.
12. Timchenko V.N. Infektsionnye bolezni u detey: Uchebnik dlya pediatricheskikh fakul’tetov meditsinskikh vuzov / Timchenko V.N., Bystryakova L.V. – SPb.: Spets.Lit., 2001. – S.198 -201.
Review
For citations:
Khokhlova Z.A., Popova O.A., Chujkova K.I., Yakimov V.L., Minakova Yu.V., Petrova E.I. INFECTIOUS MONONUCLEOSIS AT CHILDREN: FEATURES OF THE COURSE OF THE DISEASE DEPENDING ON TYPES OF ANTIVIRAL THERAPY. Journal Infectology. 2017;9(3):67-74. (In Russ.) https://doi.org/10.22625/2072-6732-2017-9-3-67-74
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