EVALUATION OF THE EFFICACY AND SAFETY OF THE ART REGIMENS CONTAINING LOW DOSES PHOSPHAZID
https://doi.org/10.22625/2072-6732-2017-9-3-61-66
Abstract
In 20 patients, treated with regime of ART including phosphazid at a dose of 800 mg/day, his daily dose was reduced to 400 mg. In 19 of 20 patients the phosphazod’ dose reduction was due to the development of adverse events related to therapy. After changing the phosphazid’ daily dose the patients seen during the 1 year. Lowering the phosphazid’ dose did not lead to virological failure of the regime of ART and/ or progression of HIV-infection. On the background of lower doses in almost all patients observed a significant improvement in health- the reduction of weakness, disappearance of nausea and headaches. The analysis of laboratory data through 48 weeks after the change daily dose of the phosphazid also showed improvement in these indicators.
About the Authors
N. V. Sizova
Center for Prevention and Control of AIDS and Infectious Diseases;
First Saint-Petersburg State Medical University named after academician I.P. Pavlov
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
I. O. Modestova
Center for Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
F. F. Shakhova
Center for Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
N. V. Koplevskaya
City Polyclinic № 95
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
O. A. Klitsenko
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
A. V. Kravchenko
Central Science Research Institute of Epidemiology
Russian Federation
Moscow
Russian Federation
Moscow
O. G. Yurin
Central Science Research Institute of Epidemiology
Russian Federation
Moscow
Russian Federation
Moscow
D. A. Gusev
Center for Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
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Review
For citations:
Sizova N.V., Modestova I.O., Shakhova F.F., Koplevskaya N.V., Klitsenko O.A., Kravchenko A.V., Yurin O.G., Gusev D.A. EVALUATION OF THE EFFICACY AND SAFETY OF THE ART REGIMENS CONTAINING LOW DOSES PHOSPHAZID. Journal Infectology. 2017;9(3):61-66. (In Russ.) https://doi.org/10.22625/2072-6732-2017-9-3-61-66
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