CONCOMITANT DISEASES AND RISK FACTORS FOR THEIR DEVELOPMENT IN PATIENTS WITH HIV INFECTION OLDER THAN 40 YEARS
https://doi.org/10.22625/2072-6732-2017-9-3-40-45
Abstract
Objective: Evaluation of CVD and their risk factors in Russian 40+ HIV-infected patients is a key objective of the study.
Materials and Methods: A retrospective analysis of 1872 medical records of 40+ HIV-infected patients from 12 regions of Russia on HAART was performed, including assessment of CVD presence, their risk factors and 10-years CVD risk based on SCORE. All patients received ARV treatment; the average duration of admission was 5 years (1–2 years – 43%, 3–5 years – 29%, over 5 years – 28%).
Results: High incidence of CVD was observed: hypertension – 48%, including cerebrovascular disease – 2%; CAD – 9%, including myocardial infarction – 6%. Analysis of cardiovascular risk factors showed that 19% were overweight, lipid metabolism disorders were detected in 30% of patients, diabetes in 5%. 51% of patients smoked, systematic intake of alcohol in 61% of patients. 69% of patients had a risk of fatal CVD within 10 years based on SCORE, 16% of patients had a high/very high risk. Analysis of metabolic parameters showed that 99,4% of patients needed lifestyle improvement measures, 85% needed lipid lowering medication. One third of patients were constantly taking cardiovascular medications.
Conclusions: CVD and metabolic disorders are more common for 40+ HIV-infected patients than for general population. ART assessment in 40+ patients additionally to viral load and CD4 level, should include analysis of cardiovascular risk factors and comorbidities. In elder patients ART regimen choice is particularly important, considering the risks of development and/or progression of CVD and risk of drugdrug interactions development.
About the Authors
D. A. Gusev
The Center on the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
S. A. Buzunova
The Center on the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
A. A. Yakovlev
Saint-Petersburg State University
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
V. B. Musatov
Saint-Petersburg State University
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
L. V. Glyzhina
Saint-Petersburg State University
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
S. A. Bykov
The Center on the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Rostov-on-Don
Russian Federation
Rostov-on-Don
E. A. Strebkova
Samara State Medical University
Russian Federation
Samara
Russian Federation
Samara
F. I. Nagimova
The Republican Center on the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Kazan
Russian Federation
Kazan
T. N. Bulatova
The Regional Center on the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Kemerovo
Russian Federation
Kemerovo
O. N. Kononchuk
The Regional Center on the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Kemerovo
Russian Federation
Kemerovo
R. G. Yapparov
The Republican Center on the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Ufa
Russian Federation
Ufa
S. V. Zajcev
The Republican Center on the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Ufa
Russian Federation
Ufa
V. N. Zapol’skaja
The Regional Center on the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Perm
Russian Federation
Perm
O. E. Chernova
The Center on the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Toliatty
Russian Federation
Toliatty
Yu. K. Plotnikova
The Regional Center on the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Irkutsk
Russian Federation
Irkutsk
V. Yu. Rozenberg
The Regional Center on the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Irkutsk
Russian Federation
Irkutsk
E. I Mironova
The Republican Center on the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Cheboksary
Russian Federation
Cheboksary
M. G. Katjagina
The Republican Center on the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Ioshkar-Ola
Russian Federation
Ioshkar-Ola
References
1. Spravka VICh-infekcija v Rossijskoj Federacii v 2016 g.
2. Nicolai Lohse et al, Survival of Persons with and without HIV Infection in Denmark,1995–2005. Ann Intern Med. Jan. 16, 2007;146:87-95
3. http://www.hiv-druginteractions.org/
4. Vsemirnyj atlas profilaktiki serdechno-sosudistyh zabolevanij i bor’by s nimi. Pod red.: Mendis S, Puska P, Norrving B. Vsemirnaja organizacija zdravoohranenija, Zheneva, 2013
5. EACS Guidelines version 8.2, January 2017
6. Rockstroh JK, DeJesus E, Lennox JL, et al. Durable efficacy and safety of raltegravir versus efavirenz when combined with tenofovir/emtricitabine in treatment-naive HIV-1-infected patients: final 5-year results from STARTMRK. J Acquir Immune Defic Syndr. May 1 2013;63(1):77-85.
7. Martinez E, Larrousse M, Llibre JM, et al. Substitution of raltegravir for ritonavir-boosted protease inhibitors in HIV infected patients: the SPIRAL study. AIDS. 2010;24(11):16971707.
Review
For citations:
Gusev D.A., Buzunova S.A., Yakovlev A.A., Musatov V.B., Glyzhina L.V., Bykov S.A., Strebkova E.A., Nagimova F.I., Bulatova T.N., Kononchuk O.N., Yapparov R.G., Zajcev S.V., Zapol’skaja V.N., Chernova O.E., Plotnikova Yu.K., Rozenberg V.Yu., Mironova E.I., Katjagina M.G. CONCOMITANT DISEASES AND RISK FACTORS FOR THEIR DEVELOPMENT IN PATIENTS WITH HIV INFECTION OLDER THAN 40 YEARS. Journal Infectology. 2017;9(3):40-45. (In Russ.) https://doi.org/10.22625/2072-6732-2017-9-3-40-45
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