СLINICAL PRESENTATION AND CONCENTRATION OF CYTOKINES SERUM OF PATIENTS WITH FORM WITHOUT ERYTHEMA OF LYME DISEASE

Purpose of the study: To investigate the role and clinical inflammatory (IL-17A, IL-23, IL-33) and anti-inflammatory (IL-35) cytokines in patients with of form without erythema of Borrelia infection.

Materials and methods: We studied 30 patients with of form without erythema of Lyme borreliosis. The diagnosis was based on epidemiological, medical history, clinical and laboratory, serological data. The blood serum interleukins level was detected from patients at admission to the infectious hospital and on the 10th day of hospitalization, as well as from 30 healthy donors. Groups of investigated persons were matched by sex and age. Blood serum analysis was carried out in the laboratory of directed regulation inter microbe interactions in the exo- and endoecological systems in Kirov State Medical University. Statistical analysis was performed using StatSoft Statistica v 10.0.

 Results: Patients with form without erythema of Lyme borreliosis oft have lesions of the respiratory system (60,0%), nervous system (53,3%), cardiac disorders (40,0%), rarely – liver disease (26,7%), joints (10,0%). In blood serum of patients with form without erythema at admission and at hospital discharge concentrations of IL-17A, IL-23, IL-33 are authentically higher compared with healthy donors. The content of anti-inflammatory IL-35 in patients with a form without erythema during hospitalization and at discharge is authentically lower than in healthy donors.

Conclusion: Patients with form without erythema of Lyme borreliosis have early combined Th1-Th2 immune response (increased content of blood serum IL-23 and IL-33). Elevated concentrations of IL-17A and IL-33 serum in patients with form without erythema indicate the presence of autoimmune or allergic reactions. Patients with form without erythema have inflammatory processes limited moderately by inflammatory reactions on the part of Treg-system (lack of IL-35 production).

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