ACUTE NEUROINFECTIONS AND SYMPTOMATIC EPILEPSY IN CHILDREN: CAUSAL RELATIONSHIP (review)
https://doi.org/10.22625/2072-6732-2017-9-3-5-13
Abstract
Convulsions in case of acute neuroinfections can both complicate the disease course and transfer to symptomatic epilepsy which is one of the most important medical and social problems. The review article presents the data on epidemiology of convulsive disorder and symptomatic epilepsy in case of neuroinfections in children. There are considered the current immune and biochemical aspects of epileptogenesis in case of infectious pathology. There is given the information on neurophysiological and radial features of symptomatic epilepsy developed in case of neuroinfections of different etiology. There is underlined the practical significance of timely complex etio-pathogenetic therapy for neuroinfections complicated by convulsion that allows to reduce the frequency of symptomatic epilepsy development. There are presented the data on the results of transcranial magnetic stimulation in case of refractory epilepsy.
About the Authors
E. Yu. Gorelik
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
V. B. Voitenkov
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
N. V. Skripchenko
Pediatric Research and Clinical Center for Infectious Diseases;
Saint-Petersburg State Pediatric Medical University
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
A. A. Vilnits
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
M. V. Ivanova
Pediatric Research and Clinical Center for Infectious Diseases;
Saint-Petersburg State Pediatric Medical University
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
A. V. Klimkin
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation
Saint-Petersburg
Russian Federation
Saint-Petersburg
References
1. Santamaria-Kisiel L. Rintala-Dempsey A., Shaw G. Calcium–dependent and –independent interactions of the S100 protein family. / Biochem J 2006; 396: 201-214.
2. Neuroinfections in children. / edited by Skripchenko NV. – S-Pb, 2015 – 856 (in Russian)
3. Kryzhanovskaya SV, Kamzalakova NI, Schneider NA, Panina Yu.S. Epilepsy and paroxysmal conditions. 2014. V4 (1): 49-56
4. Skripchenko N., Lobzin Y,. Ivanova G. Children’s infections. 2014; 13(1): 8-18 (in Russian)
5. Rosin Yu.A., Bass RL, Voitinsky E.Ya. / Predictive value of electroencephalography in severe acute neuroinfections in children. // Maternal and child care. 1999; V 36 (5): 8-12
6. Vaichene-Magistris N. Epilepsy and paroxysmal conditions. 2011; 3(4) : 42-44
7. Guzeva VI, Guzeva OV, Guzeva VV / The role of video EEG monitoring in the diagnosis of epileptic and non-epileptic paroxysmal conditions in children. // Epilepsy and paroxysmal conditions. 2010. V.3(2): 12-19
8. Hesdorffer DC., Benn EK., Cascino GD., Hauser WA. Is a first acute symptomatic seizure epilepsy? Mortality and risk for recurrent seizure. Epilepsia 2009; 50(5): 1102–1108
9. Gold J.J., Crawford J.R., Glaser C. et al. The role of continuous electroencephalography in childhood encephalitis. / Pediatr Neurol 2013; 50: 318-323
10. Misra U.K., Kalita J. Seizures in encephalitis: Predictors and outcome. / Eur J of Epilepsy 2009; 18(8): 583-587
11. Kanemura H., Sano F., Ohyama T. et al. EEG characteristics predict subsequent epilepsy in children with their first unprovoked seizure / Epilepsy Research 2015; V.115: 58-62
12. Sorokina MN., Skripchenko NV. / Viral encephalitis and meningitis in children. // Мoskow, 2004- 346 (in Russian)
13. Voitenkov V.B. Varicella Encephalitis-Related EEG Modifications in Children. / Voitenkov V.B., Komantsev V.N., Skripchenko N.V., Klimkin A.V. // Neurophysiology 2013; 45 (3): 219-222
14. Sorokina MN., Ivanova VV., Skripchenko NV. / Bacterial meningitis in children. // Мoskow, 2003 – 320 (in Russian)
15. Skripchenko N.V., Ivanova G.P. / Tick-borne diseases in children. // Moscow, 2008.- 424
16. Pitkanen A., Lukasiuk K. Mechanisms of epileptogenesis and potential treatment targets. / Lancet Neurol 2011; 10: 173186
17. Voytenkov V, Kartashev A. Reticular formation of the brain in norm and pathology. St. Petersburg; 2013 (in Russian)
18. Guzeva V.I. Manual for Pediatric Neurology. / Мoscow, 2009 – 640 (in Russian)
19. Bae E.H., Schrader L.M., Machii K., et al. Safety and tolerability of repetitive transcranial magnetic stimulation in patients with epilepsy: a review of the literature. / EpilepsyBehav 2007; 10: 521-528
20. Mukhin K.Yu., Petrukhin AS, Glukhova L.Yu. / Epilepsy. The atlas of electro-clinical diagnostics. / Мoscow, 2004 – 440 (in Russian)
21. Allen CH, Kluger BM, Buard I. Safety of Transcranial Magnetic Stimulation in Children: A Systematic Review of the Literature. / Pediatr Neurol., 2016; 68: 3-17.
22. Hsieh WB, Chiu NC, Hu KC, Ho CS, Huang FY. Outcome of herpes simplex encephalitis in children. / J MicrobiolImmunol Infect 2007; 40: 34-38.
23. Noohi S., Amirsalari S. History, studies and specific uses of repetitive transcranial magnetic stimulation (rTMS) in treating epilepsy / Iran J of child neurol; 2016, 10(1): 1–8.
24. McGrath N, Anderson NE, Croxson MC, Powell KF. Herpes simplex encephalitis treated with acyclovir: diagnosis and longtermutcome. / J Neuro lNeurosurg Psychiatry 1997; 63: 321–326.
25. Kalita J, Nair P, Misra UK. Status epilepticus in encephalitis: a study of clinical findings, magnetic resonance imaging, and response to antiepileptic drugs. / JNeurovirol2008;14: 412–417
26. Jainn-Jim Lin JJ., Lin KL., Wang HS. et al. Analysis of status epilepticus related presumed encephalitis in children / European J of Paediatr Neurol 2008; 12(1): 32-37
27. Gorelik ЕY., Skripchenko NV., Ivanova M.V. / Clinical and imaging features of acute encephalitis associated with human herpes virus 6 type in children (clinical observation example) // Infect Dis. 2016; №2: 63-68
28. Provenzale JM, vanLandingham KE, Lewis DV. et al. Extrahippocampal involvement in human herpesvirus 6 encephalitis depicted at MR imaging. / Radiology 2008; 249(3): 955-963
29. Wainwright MS, Martin PL, Morse RP. et al. Human herpesvirus 6 limbic encephalitis after stem cell transplantation. / Ann. Neurol 2001; 50 (5): 612-619
30. Kawamura Y., Sugata K., Ihira M. et al. Different characteristics of human herpesvirus 6 encephalitis between primary infection and viral reactivation. / J Clin Virol. 2011; 51(1): 12-19
31. Takaya J, Araki A, Mori K, Kaneko K. Usefulness of diffusion-weighted MRI in human herpesvirus-6 encephalitis. / Acta Paediatr 2007; 96(1): 137-138
32. Rismanchi N., Jeffrey J., Sattar S. et al. Epilepsy After Resolution of Presumed Childhood Encephalitis. / Pediatric Neurology 2015; 53(1): 65-72
33. Sabah M., Mulcahy J., Zeman A. Herpes simplex encephalitis / BMJ. 2012; 344: 148-152
34. Lee WT., YuTW.,Chang WC.,Shau WY. Risk factors for postencephalitic epilepsy in children: A hospital-based study in Taiwan / Eur J of Paediatr Neurol 2007; 11 (5): 302-309
35. Barberio M., Reiter P.D., Kaufman J. et al. Continuous infusion pentobarbital for refractory status epilepticus in children. / J Child Neurol 2011; 27: 721-726
36. Annegers JF, Hauser WA, Beghi E. et al. The risk of unprovoked seizures after encephalitis and meningitis. / Neurology 1988; 38: 1407–1410.
37. Hayashi K., Osawa M., Aihara M. et al. / Efficacy of intravenous midazolam for status epilepticus in childhood./ Pediatr Neurol 2007; 36: 366-372
38. Mazhidova EN, Khalilova AE, Sharipova N.R. Epilepsy and paroxysmal conditions. 2014. V.6 (4): 50-54
39. Fregni F., Thome-Souza S., Bermpohl F., et al. Antiepileptic effects of repetitive transcranial magnetic stimulation in patients with cortical malformations: an EEG and clinical study. / Stereotact Funct Neurosurg 2005; 83: 57-62
40. Mohanraj R., BrodieMJ. Early predictors of outcome in newly diagnosed epilepsy. / Europ J. of Epilepsy 2013; 22(5): 333-344
41. Hsu W., Cheng C., Lin M. et al. Antiepileptic effects of low frequency repetitive transcranial magnetic stimulation: a meta-analysis. / Epilepsy Res. 2011; 96: 231–240
42. Susaki J., Chegondi M., Raszynski A., Totapally B.R. Outcome of children with acute encephalitis and refractory status epilepticus. / J Child Neurol 2014; 29: 1638-1644
43. Morales OG., Henry ME., Nobler MS. et al. Electroconvulsive therapy and repetitive transcranial magnetic stimulation in children and adolescents: a review and report of two cases of epilepsiapartialis continua / Child Adolesc Psychiatr Clin North Am 2005; 14: 193-210
44. Lipatova L.V. Epilepsy and paroxysmal conditions. 2010. V.2 (3): 20-26
45. Rotenberg A., HyunjiBae E., Takeoka M. et al. Repetitive transcranial magnetic stimulation in the treatment of epilepsiapartialis continua. / Epilepsy and Behavior, 2009; 14 (1): 253-25
46. Yu N., Liu H., Di Q. Modulation of Immunity and the Inflammatory Response: A New Target for Treating Drug-resistant Epilepsy. / Curr Neuropharmacol 2013; 11(1): 114-127
47. Mazaeva E., Alekseeva L., Skripchenko N., Bessonova Т. Children›s infections. 2014; 13(1): 61-64 (in Russian).
48. Ryabukhin I.A. Nejrospecificheskie belki v ocenke pronicaemosti gematoehncefalicheskogo bar’era cheloveka i zhivotnyh [Neuro-specific proteins in assessing the permeability of the blood-brain barrier of humans and animals] (dissertation) Moscow (Russia): Russian State Medical University; 2004. 297p (in Russian)
49. Jung K.H., Chu K., Lee S.T., et al. Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. / Neurobiol Dis 2006; 23: 237-246
50. Ravizza T., Balosso S., Vezzani A. Inflammation and prevention of epileptogenesis. / Neurosci Lett 2011; 497: 223-230
51. Vezzani A., Balosso S., Ravizza T. The role of cytokines in the pathophysiology of epilepsy. / BrainBehav. Immun. 2008; 22 (6): 797–803
52. Lipatova LV, Serebryannaya NB, Sivakova NA, Vasilenko AV, Kapustina Т.V. Epilepsy and paroxysmal conditions. 2014. V6 (3): 6-12
53. Cardona A., Li M., Liu L. et al. Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation. / J. Leukoc Biol. 2008; 84(3): 587-594
54. Alexander J., Anderson A., Barnum S et al. The complement cascade: Yin–Yang in neuroinflammation – neuroprotection and –degeneration / J Neurochem 2008; 107(5): 1169–1187.
55. Libbey J., Kirkman N., Wilcox K. et al. Role for Complement in the Development of Seizures following Acute Viral Infection. / J Virol. 2010; 84(13): 6452–6460
56. Stoermer K., Morrison T. Complement and Viral Pathogenesis. / Virology 2011; 411(2): 362–373.
57. Veerhuis R, Nielsen HM, Tenner AJ. Complement in the brain / MolImmunol 2011; 48(14): 1592-603
58. Santamaria-Kisiel L. Rintala-Dempsey A., Shaw G. Calcium–dependent and –independent interactions of the S100 protein family. / Biochem J 2006; 396: 201-214.
59. Kryzhanovskaya SV, Kamzalakova NI, Schneider NA, Panina Yu.S. Epilepsy and paroxysmal conditions. 2014. V4 (1): 49-56
60. Rosin Yu.A., Bass RL, Voitinsky E.Ya. / Predictive value of electroencephalography in severe acute neuroinfections in children. // Maternal and child care. 1999; V 36 (5): 8-12
61. Guzeva VI, Guzeva OV, Guzeva VV / The role of video EEG monitoring in the diagnosis of epileptic and non-epileptic paroxysmal conditions in children. // Epilepsy and paroxysmal conditions. 2010. V.3(2): 12-19
62. Gold J.J., Crawford J.R., Glaser C. et al. The role of continuous electroencephalography in childhood encephalitis. / Pediatr Neurol 2013; 50: 318-323
63. Kanemura H., Sano F., Ohyama T. et al. EEG characteristics predict subsequent epilepsy in children with their first unprovoked seizure / Epilepsy Research 2015; V.115: 58-62
64. Voitenkov V.B. Varicella Encephalitis-Related EEG Modifications in Children. / Voitenkov V.B., Komantsev V.N., Skripchenko N.V., Klimkin A.V. // Neurophysiology 2013; 45 (3): 219-222
65. Skripchenko N.V., Ivanova G.P. / Tick-borne diseases in children. // Moscow, 2008.- 424
66. Voytenkov V, Kartashev A. Reticular formation of the brain in norm and pathology. St. Petersburg; 2013 (in Russian)
67. Bae E.H., Schrader L.M., Machii K., et al. Safety and tolerability of repetitive transcranial magnetic stimulation in patients with epilepsy: a review of the literature. / EpilepsyBehav 2007; 10: 521-528
68. Allen CH, Kluger BM, Buard I. Safety of Transcranial Magnetic Stimulation in Children: A Systematic Review of the Literature. / Pediatr Neurol., 2016; 68: 3-17.
69. Noohi S., Amirsalari S. History, studies and specific uses of repetitive transcranial magnetic stimulation (rTMS) in treating epilepsy / Iran J of child neurol; 2016, 10(1): 1–8.
70. Kalita J, Nair P, Misra UK. Status epilepticus in encephalitis: a study of clinical findings, magnetic resonance imaging, and response to antiepileptic drugs. / JNeurovirol2008;14: 412–417
71. Gorelik ЕY., Skripchenko NV., Ivanova M.V. / Clinical and imaging features of acute encephalitis associated with human herpes virus 6 type in children (clinical observation example) // Infect Dis. 2016; №2: 63-68
72. Wainwright MS, Martin PL, Morse RP. et al. Human herpesvirus 6 limbic encephalitis after stem cell transplantation. / Ann. Neurol 2001; 50 (5): 612-619
73. Takaya J, Araki A, Mori K, Kaneko K. Usefulness of diffusion-weighted MRI in human herpesvirus-6 encephalitis. / Acta Paediatr 2007; 96(1): 137-138
74. Sabah M., Mulcahy J., Zeman A. Herpes simplex encephalitis / BMJ. 2012; 344: 148-152
75. Barberio M., Reiter P.D., Kaufman J. et al. Continuous infusion pentobarbital for refractory status epilepticus in children. / J Child Neurol 2011; 27: 721-726
76. Hayashi K., Osawa M., Aihara M. et al. / Efficacy of intravenous midazolam for status epilepticus in childhood./ Pediatr Neurol 2007; 36: 366-372
77. Fregni F., Thome-Souza S., Bermpohl F., et al. Antiepileptic effects of repetitive transcranial magnetic stimulation in patients with cortical malformations: an EEG and clinical study. / Stereotact Funct Neurosurg 2005; 83: 57-62
78. Hsu W., Cheng C., Lin M. et al. Antiepileptic effects of low frequency repetitive transcranial magnetic stimulation: a meta-analysis. / Epilepsy Res. 2011; 96: 231–240
79. Morales OG., Henry ME., Nobler MS. et al. Electroconvulsive therapy and repetitive transcranial magnetic stimulation in children and adolescents: a review and report of two cases of epilepsiapartialis continua / Child Adolesc Psychiatr Clin North Am 2005; 14: 193-210
80. Rotenberg A., HyunjiBae E., Takeoka M. et al. Repetitive transcranial magnetic stimulation in the treatment of epilepsiapartialis continua. / Epilepsy and Behavior, 2009; 14 (1): 253-25
81. Mazaeva E., Alekseeva L., Skripchenko N., Bessonova Т. Children›s infections. 2014; 13(1): 61-64 (in Russian).
Review
For citations:
Gorelik E.Yu., Voitenkov V.B., Skripchenko N.V., Vilnits A.A., Ivanova M.V., Klimkin A.V. ACUTE NEUROINFECTIONS AND SYMPTOMATIC EPILEPSY IN CHILDREN: CAUSAL RELATIONSHIP (review). Journal Infectology. 2017;9(3):5-13. (In Russ.) https://doi.org/10.22625/2072-6732-2017-9-3-5-13
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