The problem of resistant Trichomonas vaginalis to antiprotozoal drugs
https://doi.org/10.22625/2072-6732-2011-3-4-34-43
Abstract
This review presents recent data on the energy metabolism of Trichomonas vaginalis and ways the activation of metronidazole. The sensitivity of microorganisms to the 5-nitroimidazole by the presence of their enzyme systems, generating and transporting electrons, which can then transfer them to the nitro group of the drug. In T.vaginalis these are pyruvate ferredoxin-oxydoreductase, thioredoxin reductase and flavin reductase. The development of resistance T.vaginalis to metronidazole preparations of this multistep process, based on the gradual reduction (up to a loss) activity hydrogenosomal enzymes and / or violation of the flavindependent metabolic pathways.
About the Authors
A. L. Poznyak
St-Petersburg Medical Academy of Postgradu ate Studies, Saint-Petersburg
Russian Federation
Russian Federation
S. S. Kozlov
Military Medical Academy by S.М. Kirov, Saint-Petersburg
Russian Federation
Russian Federation
R. V. Gudkov
Military Medical Academy by S.М. Kirov, Saint-Petersburg
Russian Federation
Russian Federation
Yu. F. Zaharkiv
Military Medical Academy by S.М. Kirov, Saint-Petersburg
Russian Federation
Russian Federation
S. N. Sidorchuk
Military Medical Academy by S.М. Kirov, Saint-Petersburg
Russian Federation
Russian Federation
O. L. Molchanov
Military Medical Academy by S.М. Kirov, Saint-Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Poznyak A.L., Kozlov S.S., Gudkov R.V., Zaharkiv Yu.F., Sidorchuk S.N., Molchanov O.L. The problem of resistant Trichomonas vaginalis to antiprotozoal drugs. Journal Infectology. 2011;3(4):34-43. (In Russ.) https://doi.org/10.22625/2072-6732-2011-3-4-34-43
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