MARKERS OF ENDOTHELIAL DYSFUNCTION IN COMPLICATED AND UNCOMPLICATED FORMS OF INFLUENZA IN CHILDREN
https://doi.org/10.22625/2072-6732-2016-8-4-66-71
Abstract
The objective: examine markers of endothelial activation in complicated and uncomplicated forms of influenza in children.
Materials and methods. The method of ELISA carried out in serum study in 114 children with uncomplicated influenza A H1N1pdm09 and 87 children with pneumonia associated with influenza virus A H1N1pdm09 some markers characterizing the endothelial dysfunction.
Results of research. It was found that the figures nitroxide producing endothelial function, the content of endothelin, von Willebrand factor antigen and functional activity in the serum of patients with a mild form of influenza A H1N1pdm09 not differ from the control values. Levels of endothelin, nitric oxide metabolites, von Willebrand factor antigen and functional activity were increased in children with development of severe and complicated course of influenza A H1N1pdm09, maximizing in severe viral and bacterial pneumonia.
Conclusion. The development of endothelial dysfunction is a key pathogenesis links the formation of heavy and complicated forms of influenza A H1N1pdm09 children.
About the Authors
N. A. Miromanova
Chita State Medical Academy
Russian Federation
Russian Federation
A. М. Miromanov
Chita State Medical Academy
Russian Federation
Russian Federation
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Review
For citations:
Miromanova N.A., Miromanov A.М. MARKERS OF ENDOTHELIAL DYSFUNCTION IN COMPLICATED AND UNCOMPLICATED FORMS OF INFLUENZA IN CHILDREN. Journal Infectology. 2016;8(4):66-71. (In Russ.) https://doi.org/10.22625/2072-6732-2016-8-4-66-71
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