Epidemiology of invasive meningococcal disease in Novosibirsk region during 1992–2015
Abstract
Aim: To study the epidemiological patterns of invasive meningococcal disease in Novosibirsk region within a time
period from 1992 to 2015.
Methods: retrospective comparative epidemiological analysis.
Results: During the analyzed period the annual incidence rate of invasive meningococcal disease was higher than average annual incidence rate in Russian Federation. Totally1690 cases were registered, average incidence rate for the period 2000–2015 was 2,2/100,000 exceeding the neighbor regions. The incidence had a tendency to continually decline and is characterized by the cyclical fluctuations with period of 4-7 years. Majority of cases occurred in children < 14 years, varying from 77,3% in 2001 to 57,8% in 2008. The highest incidence was registered in children <12 month reaching 124/100,000 of population in 2003. The increase of mortality correlated with the decrease of incidence, average mortality for period 1992–2015 was 11,4%. In etiologic structure serogroup B is predominant – 40,9%, serogrup A – 20,6%, serogrup C – 14,7%. The distinctiveness of epidemiology is cyclic dynamics with the periods of predominance of serogroup A (up to 48% in 2014). In serum analysis performed 2012 45% of probes were positive for serogroup A what demonstrates circulation of this serogoup among population.
Conclusion: High incidence among children <14 years and especially among children <12 month in emerging risk of the forthcoming rise in incidence of meningococcal disease and insufficient surveillance provide need in activation of tactics of specific immuneprophylactics.
About the Authors
I. Ya. Izvekova
Novosibirsk State Medical University, Novosibirsk, Russia
Russian Federation
Russian Federation
E. I. Krasnova
Novosibirsk State Medical University, Novosibirsk, Russia
Russian Federation
Russian Federation
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Review
For citations:
Izvekova I.Ya., Krasnova E.I. Epidemiology of invasive meningococcal disease in Novosibirsk region during 1992–2015. Journal Infectology. 2016;8(3):99-106. (In Russ.)
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