Mucormycosis in children with hematological and oncological diseases in saint-petersburg
Abstract
In prospective multicenter study were included 20 pediatriconcohematologic patients with mucormycosis. Age: 3 – 17 yy (median – 11), females – 60%. The diagnosiswas made according to EORTC/MSG 2008 criteria (post mortem – 25%). The main underlying disease was acutel eukemia (70%), risk factors – prolong severe neutropenia (median – 31 d) and lymphocytopenia (median – 33 d) after cytostatic chemotherapy or hematopoietic stem cells transplantation. Etiology agents were Lichtheimia corуmbifera, Rhizopus spp. and Rhizomucor spp. Main sites of infection were lungs (65%) and paranasal synuses (30%), dissemination – 45%. Antifungal therapy (amphotericin B lipid coplex, posaconazole, caspofungin, amphotericin B) was used in 75% patients, surgery – 30%. Overall mortality in 12 weeks was 70%.
About the Authors
N. N. Klimko
North-Western State Medical University named after I.I. Metchnikov, Saint-Petersburg, Russia
Russian Federation
Russian Federation
S. N. Khostelidi
North-Western State Medical University named after I.I. Metchnikov, Saint-Petersburg, Russia
Russian Federation
Russian Federation
E. G. Boychenko
Pediatric City Hospital № 1, Saint-Petersburg, Russia
Russian Federation
Russian Federation
A. S. Kolbin
Pediatric City Hospital № 1, Saint-Petersburg, Russia
Russian Federation
Russian Federation
A. G. Volkova
First Saint Petersburg State Medical University named after academician I.P. Pavlov, Saint-Petersburg, Russia
Russian Federation
Russian Federation
M. O. Popova
First Saint Petersburg State Medical University named after academician I.P. Pavlov, Saint-Petersburg, Russia
Russian Federation
Russian Federation
T. S. Bogomolova
North-Western State Medical University named after I.I. Metchnikov, Saint-Petersburg, Russia
Russian Federation
Russian Federation
L. S. Zuborovskaya
First Saint Petersburg State Medical University named after academician I.P. Pavlov, Saint-Petersburg, Russia
Russian Federation
Russian Federation
M. B. Belogurova
City Hospital № 31, Saint-Petersburg, Russia
Russian Federation
Russian Federation
N. V. Medvedeva
City Hospital № 31, Saint-Petersburg, Russia
Russian Federation
Russian Federation
B. V. Afanasyev
First Saint Petersburg State Medical University named after academician I.P. Pavlov, Saint-Petersburg, Russia
Russian Federation
Russian Federation
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Review
For citations:
Klimko N.N., Khostelidi S.N., Boychenko E.G., Kolbin A.S., Volkova A.G., Popova M.O., Bogomolova T.S., Zuborovskaya L.S., Belogurova M.B., Medvedeva N.V., Afanasyev B.V. Mucormycosis in children with hematological and oncological diseases in saint-petersburg. Journal Infectology. 2016;8(3):75-82. (In Russ.)
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