Immuno-morphological aspects of the pathogenesis iga-nephropathy in patients with adenovirus infection with regard to age
https://doi.org/10.22625/2072-6732-2011-3-3-74-78
Abstract
In recent years, examines the role of viral infection in the development of IgA-nephropathy. In our study, an analysis of renal biopsy tissue from 17 patients IgA-nephropathy in the presence of adenoviral antigen. Shown the presence of adenovirus infection in kidney tissue in patients with IgA-nephropathy, regardless of age: 52% of patients 60 years and 33% of patients older than 60 years. Revealed that the presence of adenovirus in the glomerular zone of influence on the severity of global sclerosis in both age groups (p <0.05) and in patients younger than 60 years the presence of adenovirus in the interstitium correlated with the severity of degeneration of the epithelium of tubules (p = 0.014). It also shows that the presence of adenovirus in the interstitium correlated with cell phenotype CD19 / λ (p = 0,004) and CD19 / κ (p = 0,002), intenstivnostyu expression of IL-10 (p = 0,029) and membranoatakuyuschego complex S5b-C9 (p = 0.011) in the glomerular zone in patients younger than 60 years. In patients older than 60 years, the influence of adenoviral infection of renal tissue to a local immune response have been identified. Based on these results, it is concluded that the presence of adenovirus infection in the kidney plays a role in the pathogenesis of IgA-nephropathy
About the Authors
I. A. Rakityanskaya
Hospital of Holy Martyr George, Saint-Petersburg
Russian Federation
Russian Federation
T. S. Ryabova
Hospital of Holy Martyr George, Saint-Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Rakityanskaya I.A., Ryabova T.S. Immuno-morphological aspects of the pathogenesis iga-nephropathy in patients with adenovirus infection with regard to age. Journal Infectology. 2011;3(3):74-78. (In Russ.) https://doi.org/10.22625/2072-6732-2011-3-3-74-78
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