Application of modern immunological methods in the diagnosis of tuberculosis in HIV-infected patients
https://doi.org/10.22625/2072-6732-2015-7-3-126-130
Abstract
Combination of TB and HIV-infection is still the most nowadays important problem, and it connects not only with steady growth of HIV infection, but with difficulties in TB diagnosis. X-ray lung studies often have unusual nature, clinical symptomatology appears when process are hard and spread. At the same time in global practice IGRAtests applying, to which they belong to SPOT.TB test and QuantiFERON®-TB Gold test, they pay great attention to it, particularly among patients with HIV- infection. In study there were data when 41 patients with lung TB were examined, 56 HIV-positive patients with lung TB and 58 healthy donors. When active TB IGRA-test and test with Diaskin test show comparable same results. Against the backdrop of HIV skin tests (Mantoux test with 2 TE and tests with Diaskin test) it was demonstrated direct dependence of level immunosuppression in contrast to IGRA – tests, that allows to carry out these researches in conditions when standard skin tests do not work.
About the Authors
A. A. Starshinova
Saint-Petersburg Science Research Institute of Phthisiopulmonology, Saint-Petersburg, Russia
Russian Federation
Russian Federation
A. M. Panteleev
City Tuberculosis Hospital № 2, Saint-Petersburg, Russia
First Saint-Petersburg State Medical University named after academician I.P. Pavlov, Saint-Petersburg, Russia
Russian Federation
Russian Federation
E. V. Vasil’eva
Saint-Petersburg Scienсe Research Institute of Epidemiology and Microbiology named after Pasteur, Saint-Petersburg, Russia
Russian Federation
Russian Federation
V. V. Manina
Saint-Petersburg Science Research Institute of Phthisiopulmonology, Saint-Petersburg, Russia
Russian Federation
Russian Federation
M. V. Pavlova
Saint-Petersburg Science Research Institute of Phthisiopulmonology, Saint-Petersburg, Russia
Russian Federation
Russian Federation
N. V. Sapozhnikova
Saint-Petersburg Science Research Institute of Phthisiopulmonology, Saint-Petersburg, Russia
Russian Federation
Russian Federation
References
1. VICh-infektsiya: klinika, diagnostika, lechenie / V.V. Pokrovskiy [i dr.]. – M.: GEOTAR - Media, 2003. – 488 s.
2. Nechaeva, O.B. Tselevye indikatory i pokazateli gosudarstvennoy programmy razvitiya zdravookhraneniya Rossii do 2020 g. / O.B. Nechaeva, S.A. Sterlikov, N.B. Khurieva // Tuberkulez i bolezni legkikh. – 2014. – № 12. – S. 25–34.
3. Yablonskiy, P.K. Rossiyskaya ftiziatriya segodnya - vybor puti razvitiya // Meditsinskiy al’yans. – 2013. – № 3. – S. 5–24.
4. Virus immunodefitsita cheloveka – meditsina / pod. red. N.A. Belyakova i A.G. Rakhmanovoy. – SPb: Baltiyskiy meditsinskiy obrazovatel’nyy tsentr, 2010.– 752 s.
5. Molekulyarno-geneticheskie tekhnologii v etiologicheskoy diagnostike disseminirovannogo tuberkuleza legkikh /V.Yu. Zhuravlev [i dr.] // Zhurn. mikrobiol. epidemiol. i immunobiologii. – 2010. – №3. – S.77-81.
6. Alekseeva, L.P. Osobennosti vyyavleniya, klinicheskogo techeniya i lecheniya bol’nykh tuberkulezom i VICh-infektsiey : avtoref. dis. … k.m.n. / L.P. Alekseeva. – M., 2008. – 22 s.
7. Profilaktika tuberkuleza u bol’nykh VICh-infektsiey /V.N. Zimina [i dr.] // Tuberkulez i bolezni legkikh. – 2013. –№ 10. – S. 3–8.
8. Kharakteristika letal’nykh iskhodov ot tuberkuleza u bol’nykh s VICh-infektsiey / A.G. Rakhmanova [i dr.] // VIChinfektsiya i immunosupressii. – 2012. – T. 4, №2. – S. 120– 123.
9. Innovatsionnye tekhnologii v diagnostike i lechenii tuberkuleznogo porazheniya / V.Yu. Zhuravlev [i dr.] // Meditsinskiy akademicheskiy zhurnal. – 2009. – № 4. – S. 68–75.
10. Tsinzerling, V.A. Tuberkulez v sochetanii s VICh-infektsiey: kliniko-morfologicheskie aspekty / V.A. Tsinzerling, V.V. Svistunov // Tuberkulez i bolezni legkikh. – 2014. – № 6. – S. 56–60.
11. Primenenie T-spot u bol’nykh VICh-infektsiey /A.M. Panteleev [i dr.] // Tuberkulez i bolezni legkikh.– 2014. – № 9. – S.52-53.
12. Yablonskiy, P.K. Znachenie sovremennykh immunologicheskikh testov v diagnostike tuberkuleza u detey /P.K. Yablonskiy [i dr.] // Meditsinskaya immunologiya. – 2013. – T. 15, № 1. – S. 37–44.
13. Starshinova, A.A. Tuberkulez u detey iz semeynogo ochaga infektsii (diagnostika, klinicheskoe techenie i profilaktika) : dis….. d-ra med. nauk / A.A. Starshinova. – SPb., 2013. –200 s.
14. Novyy kozhnyy test dlya diagnostiki tuberkuleznoy infektsii / V.I. Litvinov [i dr.] // Rossiyskiy meditsinskiy zhurnal. – 2009. – № 1.– S. 1–4.
15. Starshinova, A.A. Sovremennye immunologicheskie testy v diagnostike tuberkuleza vnutrigrudnykh limfaticheskikh uzlov u detey / A.A. Starshinova, N.V. Korneva, I.F. Dovgalyuk // Tuberkulez i bolezni legkikh. – 2011. – № 5. – S. 170–171.
16. Vozmozhnosti immunologicheskikh metodov v differentsial’noy diagnostike sarkoidoza i tuberkuleza organov dykhaniya / M.A. Belokurov [i dr.] // Zhurnal infektologii. – 2015. – T. 7, № 2. – S. 98–104.
Review
For citations:
Starshinova A.A., Panteleev A.M., Vasil’eva E.V., Manina V.V., Pavlova M.V., Sapozhnikova N.V. Application of modern immunological methods in the diagnosis of tuberculosis in HIV-infected patients. Journal Infectology. 2015;7(3):126-130. (In Russ.) https://doi.org/10.22625/2072-6732-2015-7-3-126-130
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