Epidemiological features Delta together multiple infection in Saint-Petersburg

Studied the epidemiological features of the delta as a coinfection of hepatitis B in Saint-Petersburg for 14-year period (2002–2014). Clinical and laboratory data of 232 patients admitted to Botkin CIB them during this period. Revealed a 2-fold increase in performance of co-infection (Br + + IOP HIV) by 2014. In 49,6% of patients (group 1) were diagnosed less often chronic and acute forms of HBV in combination with delta infection. In 24,5% of cases (group 2) delta infection is associated with chronic hepatitis B and C. In the remaining 25,9% of the cases (B group) occurred multiple infection
(HBV + HCV + HIV + IOP). Based on the clinical and epidemiological and laboratory data in 75,8% of patients defined delta superinfection, at 24,2% – co-infection. The marked increase in co-delta infection in recent years due to the accumulation of the potential epidemic of chronic hepatitis B in the population and the increase in the number of imported cases from 8,8% to 37,2% of migrants in the city. Cytolytic components, characterized by higher rates of ALT activity was most pronounced in the first group and the third group is minimal. However, the mean activity values for patients of the 3rd group were higher than in the first. ACAT groups had the same tendency as AlAt. Patients third group was a higher mortality, compared with other groups.

1. Farci P. Delta Hepatitis: an update J// Hepatology 2003; 39: s212-s219.

2. Stroffolini T.,Almasio P.L.,Sagnelli E. et al. Evolving clinical lands cape of chronic hepatitis B: a multicenter Italian study// J. Med Virol 2009:81. P 1999-2006.

3. Gaeta GB, Stroffolini T, Chiaramonte M, et al. Chronic hepatitis D: A vanishing disease? An Italian multicenter study// Hepatology 2000;32: P. 824–827

4. Buti M.,Homs M., Rodriquez-Frias F. et al. Clinical outcome of acute and chronic hepatitis delta in Italy. A long-term follow-up study. J Viral Hepat., 2011:18, P. 434-442.

5. Rizzetto M. and Ciancio A. Epidemiology of Hepatitis D/Seminar Liver Dis., 2012: 32., P.211-219.

6. Servant-Delmas A., Le Gal F., Gallian P. et al. Increasing prevalence of HDV/HBV infection over 15 years in France. J Clin Virol, 2014:59. P. 126-128.

7. Isembetov К.I.,Аbdurakhimov D.T., Odinzov А.V., Мuchin N.А. Risk progressirovanija i prichini letalnogo ishoda pri chronicheskom virusnom hepatite // Ross. Zhurnal Gastroenterologii, hepatologii, koloproctologii. – 2013. – T. 23. – №3. – S 49-55.

8. Maximov S.L. Klinicheskoe techenie, ischodi I lechenie virusnih hepatitiv u bolnih VICH infectiei. Avtoref. diss. … doctora medizinskih nauk. – Моslwa. – 2010. – 45 s.

9. Rizzetto M. and Alavian S.M. Hepatitis delta: the rediscovery. Clin. Liver Dis. 2013: 17. 475-487.

10. Rizzetto M. Hepatitis D virus: Introduction and Epidemiology//Cold Spring Harbor Perspectives in Medicine, 2015:5, 28July, a021576.

11. Аbdurakhimov D.T Chronicheskii hepatit B i D. М.: Гэотар-медиа, 2010. – 296 s.

12. Ziace M., Azarkar Gh. Prevalence of Hepatitis D virus Infection among Patients with chronic Hepatitis B attending Birjand Hepatitis Clinic (East of Iran), in 2012. Hepatitis Montly. 2013. 13 (8): e.11168.

13. Chulanov V.P.,Shipulina О.Y., Shipulin I.V. I drugie. Virusnie hepatiti sochetannoi etioligii. Gastroportal segolny.- www.gastroportal.ru.

14. Hajiani E., Masjedizadeh R., Hashemi J.[ et al]. Seroepidemiology of hepatitis B in Khuzestan province, Southwest Iran. Hepatitis Monthly.2009. 9: 34-38.

15. Niro G.A.,Casey J.L., Gravinese E. et al. Intrafamilian transmission of hepatitis delta virus: molecular evidence. J. Hepatology.1999. 30: 564-569.

16. Brancaccio G, Giuberti T, Verucchi G. et al. Epidemiological evolution of chronic hepatitis delta in Italy. An analysis of the master-B cohort. 2014. Dig Liv Dis 46: e12–e13.

17. Cross TJ, Rizzi P, Horner M, et al. The increasing prevalence of hepatitis delta virus (HDV) infection in south London. J Med Virol. 2008. 80: 277–282.

18. Getahun H, Baddeley A, Raviglione M. Managing tuberculosis in heople who use and inject illict drugs. Bull WHO. 2013. 91:154-156.

19. Zhavoronok S.V.,Romanovskii R.V.,Pavlovich G.L. et al. Hepatitis B and delta infections in patients with tuberculosis. Probl Tuberk, 1991. N 10, P. 34-36.

20. Galizkii L.А.,Zarezkii B.V., Lebedinez A.I. Virusnii hepatit В vo wtiziatricheskoi praktike / Bolshoi zelevoi zhurnal o tuberculose. 1999. №4. – С.1-5.

21. Nazarov V.Yu.,Nechaev V.V.,Ivanov A.K. et al. Viral hepatitis as co-infection.Of the past to the present and future. J infectology. 2013. Т. 5 (2). – S. 90-95.

22. Toossi Z. Virological and immunological impact of tuberculosis on numan immunodeficiency virus type 1 disease. J. Infect Dis. 2003; 188: 1146-1155.