Beta herpes viruses in patients with cutaneous graft-versus-host disease
https://doi.org/10.22625/2072-6732-2015-7-2-65-69
Abstract
Graft-versus-host disease is a major complication of allogenic bone marrow transplantation. Beta herpes viruses’ role in pathogenesis and prognosis of graft-versus-host disease is significant.
Objective: To study beta herpes viruses evidence in skin biopsy specimens in graft-versus-host disease patients.
Material and methods: Clinical features of 50 patients with cutaneous graft-versus-host disease were examined. Cytomegalovirus and human herpes virus 6 DNA detection in skin biopsy specimens was performed by PCR.
Results: Correlation between human herpes virus 6 and poor prognosis in graft-versus-host disease patients has been found.
Conclusion: Beta herpes virus detection after allogenic bone marrow transplantation could be important in prognosis of graft-versus-host disease.
About the Authors
V. V. Baykov
Science Research Institute of pediatric onkology, hematology and transplantation named after R.M. Gorbacheva, First Saint-Petersburg State Medical University named after academician I.P. Pavlov, Saint-Petersburg, Russia
Russian Federation
Russian Federation
I. S. Moiseev
Science Research Institute of pediatric onkology, hematology and transplantation named after R.M. Gorbacheva, First Saint-Petersburg State Medical University named after academician I.P. Pavlov, Saint-Petersburg, Russia
Russian Federation
Russian Federation
A. Yu. Petrova
Dermatovenereology outpatient clinic No 4, Saint-Petersburg, Russia
Russian Federation
Russian Federation
E. V. Lisukova
Science Research Institute of pediatric onkology, hematology and transplantation named after R.M. Gorbacheva, First Saint-Petersburg State Medical University named after academician I.P. Pavlov, Saint-Petersburg, Russia
Russian Federation
Russian Federation
I. E. Belousova
Military Medical Academy named after S.M. Kirov, Saint-Petersburg, Russia
Russian Federation
Russian Federation
I. O. Smirnova
Saint-Petersburg State University, Saint-Petersburg, Russia
Russian Federation
Russian Federation
I. N. Telichko
Dermatovenereology outpatient clinic No 4, Saint-Petersburg, Russia
Russian Federation
Russian Federation
References
1. Jacobsohn D.A., Vogelsang G. Acute graft versus host disease // Orphanet journal of Rare Diseases. – 2007. – Vol. 4. – N.2. – P. 35
2. Lancini D., Flower R., Hogan C. Cytomegalovirus disease in immunocompetent adults // The Medical Journal of Australia. – 2014. – Vol. 201. – N.10. – p. 578-580.
3. Jang J.E., Cheong J.W., Hyun S.Y., Kim Y.D., Kim Y.R., Kim J.S., Min Y.H. Early CMV replication and subsequent chronic GVHD have a significant anti-leukemic effect after allogeneic HSCT in acute myeloid leukemia // Annals of hematology. – 2015. – Vol. 94. – N.2. – p. 275-282.
4. Hermouet S., Rose T.M., Greenblatt R.J., Corre I., Garand R., Neves A.M., Bataille R., Casey J.W. Qualitative and quantitative analysis of human herpesviruses in chronic and acute B cell lymphocyticleukemia and in multiple myeloma // Leukemia. – 2003. – Vol. 17. – p. 185-195.
5. Elmaagacli A.H., Koldehoff M., Hegerfeldt Y., Trenschel R., Ditschkowski M., Christoph S., Gromke T., Kordelas L., Ottinger H.D., Ross R.S., Horn P.A., Schnittger S., Beelen D.W. Early human cytomegalovirus replication after transplantation is associatedwith a decreased relapse risk: evidence for a putative virus-versusleukemiaeffect in acute myeloid leukemia patients // Blood. – 2011. – Vol. 118. – p. 1402-1412.
6. Barrett A.J. CMV: when bad viruses turn good // Blood. – 2011. – Vol. 118. – N.5. – p. 1193-1194.
7. Appleton A.L., Peiris J.S., Taylor C.E., Wilkes J., Green M.A., Pearson A.D., Proctor S.J., Hamilton P.J., Cant A.J. Role of target organ infection with cytomegalovirus in the pathogenesis of graft-versus-host disease // Bone Marrow Transplantation. – 1995. – Vol. 15. – N.4. – p. 557-561.
8. Pichereau C., Janin A., Scieux C., Peffault de Latour R., Xhaard A., Robin M., Ribaud P., Agbalika F., Chevret S., Socie G. The complex relationship between human herpesvirus 6 and acute graft-versus-host disease // Biology of Blood and Marrow Transplantation. – 2012. – Vol. 18. – N.1. – p. 141-144.
9. Wang L.R., Zhang M.J., Lu D.P. Correlations of human herpesvirus 6B and CMV infection with acute GVHD in recipients of allogeneic haematopoietic stem cell transplantation // Bone Marrow Transplantation. – 2008. – Vol. 42. – N.10. – p. 673-677.
10. Yoshikawa T., Ohashi M., Suga S., Asano Y., Miyazaki H., Hirano M., Suzuki K., Matsunaga K., Horibe K., Kojima S., Kudo K., Kato K., Matsuyama T., Nishiyama Y. Correlation between HHV-6 infection and skin rash after allogeneic bone marrow transplantation // Bone Marrow Transplantation – 2001. – Vol. 28. – N.1. – p. 77-81.
11. Przepiorka D., Martin P. Consensus Conference on Acute GVHD Grading // Bone Marrow Transplantation. – 1995. – Vol. 15. – N.6. – p. 825-828.
12. Horn T.D., Vogelsang G.B., Wingard J.R., Santos G.W. Cutaneous graft-versus-host reaction lacks evidence of cutaneous cytomegalovirus by the immunoperoxidase technique // Journal of Investigative Dermatology. – 1989. – Vol. 93. – N.1. – p. 92-95.
13. de Pagter P.J., Visscher H., de Vos M., Bierings M., van Loon A.M., Uiterwaal C.S., van Baarle D., Sanders E.A., Boelens J. Human herpes virus 6 plasma DNA positivity after hematopoietic stem cell transplantation in children: an important risk factor for clinical outcome // Biology of Blood and Marrow Transplantation. – 2008. – Vol. 14. – N.7. – p. 831-839.
14. Appleton A.L., Peiris J.S., Taylor C.E., Wilkes J., Green M.A., Pearson A.D., Kelly P.J., Malcolm A.J., Proctor S.J. Human herpes virus-6 infection in marrow graft recipients: role in pathogenesis of graft-versus-host disease. Newcastle upon Tyne Bone Marrow Transport Group // Bone Marrow Transplantation. – 1995. – Vol. 16. – N.6. – p. 777-782.
15. Dulery R., Dewilde A., Rossignol J., Boyle E.M., Gay J., de Berranger E., Coiteux V., Jouet J.P., Duhamel A., YakoubAgha I. Early human herpesvirus type 6 reactivation after allogeneic stem cell transplantation: a large-scale clinical study // Biology of Blood and Marrow Transplantation. – 2012. – Vol. 18. – N.7. – p. 1080-1089.
16. de Pagter P.J., Keukens L., Schutten M., Cornelissen J.J., van Baarle D., Fries E., Sanders E.A., Minnema M.C., van der Holt B.R., Meijer E., Boelens J.J. Human herpes virus 6 reactivation: important predictor for poor outcome after myeloablative, but not non-myeloablative allo-SCT // Bone Marrow Transplantation. – 2013. – Vol. 48. – N.11. – p. 1460-1464.
17. Gotoh M., Katagiri S., Suguro T., Asano M., Kitahara T., Akahane D., Okabe S., Tauchi T., Ito Y., Ohyashiki K. Human herpesvirus 6 reactivation on the 30th day after allogeneic hematopoietic stem cell transplantation can predict grade 2-4 acute graft-versus-host disease // Transplant Infectious Disease. – 2014. – Vol. 16. – N.3. – p. 440-449.
Review
For citations:
Baykov V.V., Moiseev I.S., Petrova A.Yu., Lisukova E.V., Belousova I.E., Smirnova I.O., Telichko I.N. Beta herpes viruses in patients with cutaneous graft-versus-host disease. Journal Infectology. 2015;7(2):65-69. (In Russ.) https://doi.org/10.22625/2072-6732-2015-7-2-65-69
Views:
658
.png)
.png)
Email this article 