Iron metabolism in chronic hepatitis C patients on antiviral treatment
https://doi.org/10.22625/2072-6732-2009-1-1-41-48
Abstract
Purpose of the present research studying dynamics of the parameters describing a metabolism of iron at chronic hepatitis С patients on a combined antiviral therapy peg-interferon-2а and ribavirin. Has served 50 patients chronic hepatitis C (anti-HCV “+”, РНК HCV “+”, 1b genotype) in the age from 18 till 59 years, on the average 33±1,5years, at various stages of disease and stages of monitoring antiviral treatments. To patients the parameters describing a metabolism of iron (serum iron, transferrin, ferritin, haptoglobin, ceruplasmin, total iron binding capacity, transferrin saturation by iron were defined. The sustain virology response (SVR) was estimated - definition RNA HCV in half a year after end of treatment (72 week). It was carried out liver biopsy with the subsequent estimation of a degree of inflammatory activity and fibrosis on system METAVIR. Therapy peg-interferon-2а and ribavirin was accompanied by decrease serum iron, transferrin, ferritin, ceruplasmin, haptoglobin, transferrin saturation by iron irrespective of the answer to treatment. Thus, SVR directly correlated with higher level of iron and ceruplasmin of blood before therapy, on its background and during supervision. Normalization of biochemical activity chronic hepatitis C and positive morphological dynamics correspond with the parameters describing changes in a metabolism of iron at its patients, possibly, were compensatory-adaptive and to some extent endogen antiviral reaction of an organism of the person on HCV - infection.
About the Authors
K. V. Zhdanov
Military Medical Academy by S.M. Kirov
Russian Federation
Russian Federation
D. A. Gusev
Military Medical Academy by S.M. Kirov
Russian Federation
Russian Federation
V. S. Chirskiy
Military Medical Academy by S.M. Kirov
Russian Federation
Russian Federation
K. V. Kozlov
Military Medical Academy by S.M. Kirov
Russian Federation
Russian Federation
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Review
For citations:
Zhdanov K.V., Gusev D.A., Chirskiy V.S., Kozlov K.V. Iron metabolism in chronic hepatitis C patients on antiviral treatment. Journal Infectology. 2009;1(1):41-48. (In Russ.) https://doi.org/10.22625/2072-6732-2009-1-1-41-48
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