New aspects of the pathogenesis of acute brucellosis
https://doi.org/10.22625/2072-6732-2026-18-2-101-106
Abstract
The problem of brucellosis at the current stage determines the need to study the pathophysiological features of the infection, including the assessment of the significance of changes in the functions of platelets, vascular endothelium, and the immune system in the pathogenesis of the disease.
The aim of the study is to determine the significance of inflammation factors, hemostasis, and indicators of endothelial dysfunction in the development of clinical and pathophysiological changes in acute brucellosis.
Materials and methods of the study: 78 patients aged 19 to 68 with acute brucellosis were under observation during inpatient treatment. All patients underwent a comprehensive clinical and laboratory examination, including testing for inflammatory and hemostatic markers.
Results: In patients with acute brucellosis, thrombocytopathy is observed despite normal platelet counts. Lipid A, a component of lipopolysaccharide (LPS) from Brucella, interacts with the platelet membrane, inhibiting activation and aggregation processes. The structural features of lipid A in Brucella LPS limit its ability to actively recruit Hageman factor (XII) into the hemostatic cascade, thereby reducing the level of inflammatory reactions. Relatively long-term persistence of Brucella in the body leads to mild (moderate) inflammation and is accompanied by a hemostatic balance between the coagulation and anticoagulation systems of the blood, indicating a sufficient adaptive response that prevents the development of thrombotic complications. An increase in the level of endothelial dysfunction indicators (due to the influence of inflammatory mediators released by platelets), acute phase proteins of inflammation, and the appearance of an Mpeak in the region of γ-globulins against the background of dysproteinemia were shown.
Conclusion: The pathogenesis of acute brucellosis has been determined, including the formation of a systemic inflammatory response against a background of changes in the blood coagulation system and endothelial dysfunction caused by the action of Brucella LPS.
About the Authors
N. S. Sarkisyan
Stavropol Plague Control Institute
Russian Federation
Competing Interests:
Russian Federation
Stavropol
Competing Interests:
none
A. N. Kulichenko
Stavropol Plague Control Institute
Russian Federation
Competing Interests:
Russian Federation
Stavropol
Competing Interests:
none
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Review
For citations:
Sarkisyan N.S., Kulichenko A.N. New aspects of the pathogenesis of acute brucellosis. Journal Infectology. 2026;18(2):101-106. (In Russ.) https://doi.org/10.22625/2072-6732-2026-18-2-101-106
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