The role of human betaherpesviruses 6A and 6B in the pathogenesis of multiple sclerosis: a modern view of the problem
https://doi.org/10.22625/2072-6732-2026-18-2-17-29
Abstract
The role of human herpes virus 6A and human herpes virus 6B in the pathogenesis of multiple sclerosis remains a matter of debate, largely due to the multifactorial nature of the neurological disease. This review systematizes data on the potential effect of human herpes viruses 6A and 6B on the occurrence and/or development of multiple sclerosis. The facts of the detection of laboratory diagnostic markers of beta-herpesviruses in patients with multiple sclerosis are highlighted. Hypothetical mechanisms of the pathogenesis of multiple sclerosis involving human herpes viruses 6A and 6B (molecular mimicry, incorporation of host cell proteins), including as part of a mixed infection with other viruses, are described. The mechanisms of activation of the immune system and the development of neuroinflammation under the influence of these beta-herpesviruses are considered. The main problems, unresolved issues and directions for future research in the context of the role of human herpes viruses 6A and 6B in multiple sclerosis are described.
About the Authors
N. A. Suslov
Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology named after аcademician I.N. Blokhina
Russian Federation
Competing Interests:
Russian Federation
Nizhny Novgorod
Competing Interests:
none
A. E. Hrulev
Privolzhsky Research Medical University
Russian Federation
Competing Interests:
Russian Federation
Nizhny Novgorod
Competing Interests:
none
E. N. Filatova
Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology named after аcademician I.N. Blokhina
Russian Federation
Competing Interests:
Russian Federation
Nizhny Novgorod
Competing Interests:
none
N. Zajceva
Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology named after аcademician I.N. Blokhina
Russian Federation
Competing Interests:
Russian Federation
Nizhny Novgorod
Competing Interests:
none
I. N. Vaneev
Privolzhsky Research Medical University
Russian Federation
Competing Interests:
Russian Federation
Nizhny Novgorod
Competing Interests:
none
O. V. Utkin
Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology named after аcademician I.N. Blokhina
Russian Federation
Competing Interests:
Russian Federation
Nizhny Novgorod
Competing Interests:
none
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For citations:
Suslov N.A., Hrulev A.E., Filatova E.N., Zajceva N., Vaneev I.N., Utkin O.V. The role of human betaherpesviruses 6A and 6B in the pathogenesis of multiple sclerosis: a modern view of the problem. Journal Infectology. 2026;18(2):17-29. (In Russ.) https://doi.org/10.22625/2072-6732-2026-18-2-17-29
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