jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2026-18-2-17-29jofin-1985Research ArticleОБЗОРREVIEWРоль бета-герпес-вирусов 6a и 6b в патогенезе рассеянного склероза: современный взгляд на проблемуThe role of human betaherpesviruses 6A and 6B in the pathogenesis of multiple sclerosis: a modern view of the problemСусловН. А.SuslovN. A.

Суслов Никита Алексеевич – лаборант лаборатории молекулярной биологии и биотехнологии.

Нижний Новгород, тел.: 8(831)469-79-46, факс: 8(831)469-79-20

Nizhny Novgorod

suslovnikita98gr@gmail.comХрулевА. Е.HrulevA. E.

Хрулев Алексей Евгеньевич – профессор кафедры нервных болезней Приволжского ИМУ, д.м.н., доцент.

Нижний Новгород, тел.: +7-903-607-24-64

Nizhny Novgorod

alexey_khrulev@mail.ruФилатоваЕ. Н.FilatovaE. N.

Филатова Елена Николаевна – ведущий научный сотрудник лаборатории молекулярной биологии и биотехнологии Нижегородского научно-исследовательского института эпидемиологии и микробиологии им. академика И.Н. Блохиной, к.б.н.

Нижний Новгород; тел.: 8(831)469-79-46, факс: 8(831)469-79-20

Nizhny Novgorod

el.filatova83@mail.ruЗайцеваН. Н.ZajcevaN.

Зайцева Наталья Николаевна – директор Нижегородского научно-исследовательского института эпидемиологии и микробиологии им. академика И.Н. Блохиной, д.м.н., профессор.

Нижний Новгород; тел.: 8(831)469-79-01, факс: 8(831)469-79-20

Nizhny Novgorod

nniiem@yandex.ruВанеевИ. Н.VaneevI. N.

Ванеев Иван Николаевич – студент 6 курса лечебного факультета.

Нижний Новгород; тел.: +7-902-885-73-88

Nizhny Novgorod

polina_popova43@mail.ruУткинО. В.UtkinO. V.

Уткин Олег Владимирович – ведущий научный сотрудник – заведующий лабораторией молекулярной биологии и биотехнологии Нижегородского научно-исследовательского института эпидемиологии и микробиологии им. академика И.Н. Блохиной, к.б.н.

Нижний Новгород; тел.: 8(831) 469-79-45, факс: 8(831)469-79-20

Nizhny Novgorod

utkino2004@mail.ruНижегородский научно-исследовательский институт эпидемиологии и микробиологии им. академика И.Н. БлохинойРоссияNizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology named after аcademician I.N. BlokhinaRussian FederationПриволжский исследовательский медицинский университетРоссияPrivolzhsky Research Medical UniversityRussian Federation2026200620261821729Copyright © Суслов Н.А., Хрулев А.Е., Филатова Е.Н., Зайцева Н.Н., Ванеев И.Н., Уткин О.В., 20262026Суслов Н.А., Хрулев А.Е., Филатова Е.Н., Зайцева Н.Н., Ванеев И.Н., Уткин О.В.Suslov N.A., Hrulev A.E., Filatova E.N., Zajceva N., Vaneev I.N., Utkin O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/1985

Роль вируса герпеса человека 6A и вируса герпеса человека 6B в патогенезе рассеянного склероза остается предметом дискуссий, что во многом обусловлено мультифакторной природой заболевания. В данном обзоре систематизированы данные о потенциальном влиянии вирусов герпеса человека 6A и 6B на возникновение и/ или развитие рассеянного склероза. Приведены факты обнаружения лабораторно-диагностических маркеров рассматриваемых бета-герпес-вирусов у пациентов с рассеянным склерозом. Описаны гипотетические механизмы патогенеза рассеянного склероза при участии вирусов герпеса человека 6A и 6B (молекулярная мимикрия, включение белков клетки-хозяина), в том числе в виде микст-инфекции с другими вирусами. Рассмотрены механизмы активации иммунной системы и развития нейровоспаления при воздействии данных бетагерпес-вирусов. Описаны основные проблемы, нерешенные вопросы и направления для будущих исследований в контексте роли вирусов герпеса человека 6A и 6B как участников патогенеза рассеянного склероза.

The role of human herpes virus 6A and human herpes virus 6B in the pathogenesis of multiple sclerosis remains a matter of debate, largely due to the multifactorial nature of the neurological disease. This review systematizes data on the potential effect of human herpes viruses 6A and 6B on the occurrence and/or development of multiple sclerosis. The facts of the detection of laboratory diagnostic markers of beta-herpesviruses in patients with multiple sclerosis are highlighted. Hypothetical mechanisms of the pathogenesis of multiple sclerosis involving human herpes viruses 6A and 6B (molecular mimicry, incorporation of host cell proteins), including as part of a mixed infection with other viruses, are described. The mechanisms of activation of the immune system and the development of neuroinflammation under the influence of these beta-herpesviruses are considered. The main problems, unresolved issues and directions for future research in the context of the role of human herpes viruses 6A and 6B in multiple sclerosis are described.

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The authors declare that there are no conflicts of interest present.