Prediction of unfavorable outcome of sepsis in children
https://doi.org/10.22625/2072-6732-2025-17-4-73-78
Abstract
Sepsis remains a serious problem leading to high morbidity and mortality in children. Early detection and treatment are of primary importance for successful treatment of sepsis. Comprehensive treatment of sepsis based on the implementation of protocols, use of available resources and advanced technologies is the key to reducing mortality.
The aim of our study was to find predictors of unfavorable course of sepsis in children with subsequent creation of a prediction model.
Materials and methods: we analyzed 178 cases of sepsis with septic shock in children with an assessment of hematological, biochemical parameters and the severity of multiple organ failure (according to the Prism, Pelod-2, pSofa and Phoenix scales) in order to identify significant indicators that correlate with the development of an unfavorable outcome.
Results: models were compiled that included indicators that correlated with the lethal outcome of sepsis and, based on the assessment of the performance parameters of the models, the best one was selected, subsequently a nomogram was developed to determine the probability of an unfavorable (lethal) outcome in pediatric patients with sepsis.
About the Authors
E. N. Sergienko
Belarusian State Medical University
Belarus
Belarus
Minsk
O. N. Romanova
Belarusian State Medical University
Belarus
Belarus
Minsk
O. V. Krasko
Joint Institute of Informatics Problems of the National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
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Review
For citations:
Sergienko E.N., Romanova O.N., Krasko O.V. Prediction of unfavorable outcome of sepsis in children. Journal Infectology. 2025;17(4):73-78. (In Russ.) https://doi.org/10.22625/2072-6732-2025-17-4-73-78
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