Peculiarities of genetic regulation of human susceptibility to viral infections
https://doi.org/10.22625/2072-6732-2025-17-4-35-50
Abstract
The functioning of the human genome plays a role in protecting the body from viral invasion. The body’s susceptibility to various viral diseases is determined not only by the functioning of the innate and adaptive immune systems but also by individual genomic differences. Mutations in the FUT2 gene region can exert a protective effect against norovirus gastroenteritis, but also increase the risk of developing and complicating other diseases. The molecular mechanism of interaction between OAS family genes and the innate immune system, as well as the characteristics of normal genomic polymorphism, influence the development and favorable outcome of viral diseases.
An analysis of information sources on the relationship between genomic processes and the course and outcome of viral diseases, as well as individual aspects of the influence of disease characteristics on these processes, was conducted as of July 2025. The following keywords were used in key electronic databases, including PubMed, Scopus, eLIBRARY, and Google Scholar: FUT, OAS, HDAC, epigenetics, immune resistance, viral diseases, and host immunity.
Several mechanisms of the influence of epigenetic processes on the course of diseases, as well as the possibilities for their therapeutic correction, are presented. Research into the fundamental aspects of the influence of genetic control mechanisms on susceptibility to viral infections will allow for new understanding of risk groups and mechanisms for disease prevention and treatment.
About the Authors
D. A. Verbenko
Federal Research Institute of Viral Infections ‘Virom’
Russian Federation
Russian Federation
Ekaterinburg
V. A. Belyaev
Federal Research Institute of Viral Infections ‘Virom’
Russian Federation
Russian Federation
Ekaterinburg
A. E. Panova
Federal Research Institute of Viral Infections ‘Virom’
Russian Federation
Russian Federation
Ekaterinburg
M. A. Vashukova
National Medical Research Center named after V.A. Almazov;
Infectious Diseases Hospital named after S.P. Botkin
Russian Federation
Russian Federation
Saint-Petersburg
A. V. Semenov
Federal Research Institute of Viral Infections ‘Virom’
Russian Federation
Russian Federation
Ekaterinburg
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For citations:
Verbenko D.A., Belyaev V.A., Panova A.E., Vashukova M.A., Semenov A.V. Peculiarities of genetic regulation of human susceptibility to viral infections. Journal Infectology. 2025;17(4):35-50. (In Russ.) https://doi.org/10.22625/2072-6732-2025-17-4-35-50
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