Clinical case of Long-COVID complicated by the development of pneumocystis pneumonia in patient with follicular lymphoma
https://doi.org/10.22625/2072-6732-2025-17-3-157-161
Abstract
The COVID-19 pandemic has led to global consequences, including Long-COVID. This term is used to refer to the symptoms of a new coronavirus infection that last more than 4 weeks, but less than 12 weeks from the onset of the disease. The most common symptoms are shortness of breath, cough, and general weakness. The risk group for the long-term course of COVID-19 includes patients with immunodeficiency. One of the reasons for the long-term persistence of symptoms is the persistence of the virus in the body. However, in 30–40% of cases, the results of the SARS-CoV-2 test turn out to be negative, which makes it difficult to make a diagnosis. In addition, patients with immunodeficiency against Long-COVID may develop opportunistic infections caused by reactivated opportunistic microflora against the background of lymphopenia. The presented clinical example demonstrates a case of Long-COVID infection complicated by the development of pneumocystis pneumonia in a patient with follicular lymphoma. Timely diagnosis and initiation of specific treatment made it possible to stabilize the patient’s condition and prevent the fulminant course of pneumocystis infection.
About the Authors
A. A. DeminaRussian Federation
Moscow
Competing Interests:
None
D. A. Kutsakina
Russian Federation
Moscow
Competing Interests:
None
N. A. Nikolaeva
Russian Federation
Moscow
Competing Interests:
None
O. O. Voronkova
Russian Federation
Moscow
Competing Interests:
None
D. A. Budanova
Russian Federation
Moscow
Competing Interests:
None
E. F. Rogova
Russian Federation
Moscow
Competing Interests:
None
M. V. Kozhevnikova
Russian Federation
Moscow
Competing Interests:
None
Yu. N. Belenkov
Russian Federation
Moscow
Competing Interests:
None
References
1. https://data.who.int/dashboards/covid19/cases?n=c
2. Healthcare in Russia. 2023: Stat.sat./Rosstat, Moscow, 2023, 181 p.
3. Gao Y.D., Ding M. et al. Risk factors for severe and critically ill COVID-19 patients: A review. Allergy. 2021;76(2):428–455. https://doi.org/10.1111/all.14657.
4. Nalbandian A., Sehgal K. et al. Post-acute COVID-19 syndrome. Nature medicine. 2021 Apr;27(4):601-15. https://doi.org/10.1038/s41591-021-01283-z.
5. Management of patients with long-term COVID and post-covid complications (including antiviral/immunomodulatory therapy). Algorithms for diagnosis and treatment. Therapy. 2023; 9(4S): 34–50. https://doi.org/10.18565/therapy.2023.4suppl.34-50.
6. Methodological recommendations “Features of the course of Long-term COVID infection. Therapeutic and rehabilitation measures”. Therapy. 2022; 1 (Appendix): 1-147. https://doi.org/10.18565/therapy.2022.1suppl.1-147.
7. Zhou F., Yu T. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020; 395(10229): 1054–62. https://doi.org/10.1016/S0140-6736(20)30566-3.
8. Carmo A., Pereira-Vaz J. et al. Clearance and persistence of SARS-CoV-2 RNA in COVID-19 patients. J Med Virol. 2020; 92(10): 2227–31. https://doi.org/10.1002/jmv.26103.
9. Liu Y., Yan L.-M. et al. Viral dynamics in mild and severe cases of COVID-19. Lancet Infect Dis. 2020; 20(6): 656–57. https://doi.org/10.1016/S1473-3099(20)30232-2.
10. Fung M., Babik J.M. COVID-19 in immunocompromised hosts: What we know so far. Clin Infect Dis. 2021; 72(2): 340–50. https://doi.org/10.1093/cid/ciaa863.
11. Pinato D.J., Tabernero J. et al.; OnCovid study group. Prevalence and impact of COVID-19 sequelae on treatment and survival of patients with cancer who recovered from SARS-CoV-2 infection: evidence from the OnCovid retrospective, multicentre registry study. Lancet Oncol. 2021. 2212. https://doi.org/10.1016/S1470-2045(21)00573-8.
12. Averyanov A.V., Sotnikova A.G., Lesnyak V.N. Pneumocystis pneumonia mimicking COVID-19. Clinical practice. 2020;11(2):87–92. https://doi.org/10.17816/clinpract34995.
13. Choi Y.J., Seo Y.B. et al. A Systematic Review and Meta-Analysis. J Clin Med. 2023 Nov 28;12(23):7375. https://doi.org/10.3390/jcm12237375.
Review
For citations:
Demina A.A., Kutsakina D.A., Nikolaeva N.A., Voronkova O.O., Budanova D.A., Rogova E.F., Kozhevnikova M.V., Belenkov Yu.N. Clinical case of Long-COVID complicated by the development of pneumocystis pneumonia in patient with follicular lymphoma. Journal Infectology. 2025;17(3):157-161. (In Russ.) https://doi.org/10.22625/2072-6732-2025-17-3-157-161