Immunopathogenesis of infectious-inflammatory diseases of central nervous system
https://doi.org/10.22625/2072-6732-2011-3-2-28-32
Abstract
The revue includes the contemporary information about the role of resident cells of the CNS (astrocytes, microglia) in development of innate immune response against pathogen (or its products) invasion in the brain. The detection of invading pathogens by pattern-recognition (Toll-like) receptors of neuroglia is described. Also is described the production by these cells of inflammatory mediators, including proinflammatory cytokines, as well as inflammation downregulating factors that protect the CNS from alteration and degeneration.
About the Authors
G. F. Zheleznikova
Research Institute of Children Infections, FMBA Russia, Saint-Petersburg
Russian Federation
Russian Federation
N. V. Skripchenko
Research Institute of Children Infections, FMBA Russia, Saint-Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Zheleznikova G.F., Skripchenko N.V. Immunopathogenesis of infectious-inflammatory diseases of central nervous system. Journal Infectology. 2011;3(2):28-32. (In Russ.) https://doi.org/10.22625/2072-6732-2011-3-2-28-32
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