Influenza vaccination and cytokine profile dynamics in young men in Primorsky krai
https://doi.org/10.22625/2072-6732-2024-16-4-78-84
Abstract
Seasonal vaccination against influenza is considered the most effective method of specific prevention of this infection. However, in recent years, the issue of nonspecific, training effects of vaccines on the immune system has been widely studied. One of the mechanisms of implementation may be a change in the production of cytokines in vaccinated people.
Purpose of the study: to study the dynamics of proinflammatory and antiinflammatory cytokines before and after vaccination against influenza.
Materials and methods: The study involved 75 young men, the average age was 18.7±0.8 years, who were vaccinated with the Sovigripp vaccine. Those included in the study had two blood samples: (1) – before the flu vaccination; (2) – one month after the flu vaccination. Serum levels of proand antiinflammatory cytokines were determined by solidphase enzyme immunoassay: IL1β, IL4, IL6, IL8, IL10, IL17, IFNγ, TNFα. The results were recorded using an automatic enzyme immunoassay analyzer. Statistical processing of the obtained results was carried out using the STATISTICA 10 software package.
Results: In the analysis of cytokines before vaccination, an increase in IL8, IL17 and IL6 levels was detected in 100% of cases – in 76% of cases. Within the generally accepted norms, only TNFa was determined in 92% of the surveyed population. The remaining indicators were reduced: IFNγ – in 100%, IL1β and IL4 – in more than 80% and IL10 – in 50% of cases. After influenza vaccination, there was a noticeable tendency to decrease the levels of all cytokines compared to baseline values.
Conclusion: The results of the study revealed features in cytokine levels before and after influenza vaccination in healthy young people, which were characterized by deviations from the norm in both directions.
About the Authors
Yu. A. Li
Pacific State Medical University
Russian Federation
Competing Interests:
Russian Federation
Vladivostok
Competing Interests:
none
M. N. Dmitrachenko
Pacific State Medical University
Russian Federation
Competing Interests:
Russian Federation
Vladivostok
Competing Interests:
none
M. P. Kostinov
Research Institute of Vaccines and Serums named after I.I. Mechnikov; First Moscow State Medical University named after I.M. Sechenov
Russian Federation
Competing Interests:
Russian Federation
Moscow
Competing Interests:
none
E. V. Markelova
Pacific State Medical University
Russian Federation
Competing Interests:
Russian Federation
Vladivostok
Competing Interests:
none
I. V. Korolev
Pacific State Medical University
Russian Federation
Competing Interests:
Russian Federation
Vladivostok
Competing Interests:
none
S. L. Saprykin
The Pacific Fleet of the Ministry of Defense of the Russian Federation
Russian Federation
Competing Interests:
Russian Federation
Vladivostok
Competing Interests:
none
References
1. Kostinov M.P., Tyukavkina S.Yu., Kharseeva G.G., Nastaeva N.Yu. Efficiency of influenza vaccination in the context of the COVID-19 pandemic (material for preparing a lesson). Infectious diseases: news, opinions, training, 2023, Vol. 12, no. 4, pp. 90–99. DOI: 10.33029/2305-3496-2023-12-4-90-99.
2. Shamsheva O.V. Vaccination and human health. Children’s infections, 2015,Vol. 14, no. 4. pp. 6-12. DOI: 10.22627/2072-8107-2015-14-4-6-12
3. Priority vaccination against respiratory infections during the SARS-COV-2 pandemic and after its completion. A manual for doctors. Edited by M.P. Kostinov, A.G. Chuchalin. ulcer. Мoscow: MDV Group, 2020, 32 p. ISBN 976-5-906748-16-4
4. Krylova N.V., Leonova G.N., Pavlenko E.V. Features of the cytokine profile in the early stages of infection with tickborne encephalitis virus in vaccinated and unvaccinated people. Pacific Medical Journal, 2012, no. 4, pp. 78-81.
5. Kostinov M.P. Immunopathogenic properties of SARSCoV-2 as a basis for choosing pathogenetic therapy. Immunology, 2020, Vol. 41, no. 1, pp. 83–91. DOI: 10.33029/0206-4952-2020-41-1-83-91
6. Kostinov M.P. Domestic immunotropic agents in the prevention, therapy and rehabilitation of patients with COVID-19. Monograph. ulcer.Мoscow: MDV Group, 2024, 172 p. ISBN 978-5-906748-27-0
7. Yushkova S.V., Kostinov M.P., Gladkova L.S., Kameleva A.A., Kachnova A.S., Kostinova A.M., Solovyova I.L., Andreeva N.P., Dagil Yu.A., Nastaeva N.Yu., Kryukova N.O., Loktionova M.N. Level of antibodies to influenza virus strains in healthy vaccinated people at the end of the COVID-19 pandemic. Infection and Immunity, 2024, Vol. 14, no. 1, pp. 57–65. DOI: 10.15789/2220-7619-LOI-17598
8. Tang W., Xie H., Ye Z. et al. Post-vaccination serum cytokines levels correlate with breakthrough influenza infections. Sci Rep., 2023, Vol.13, no. 1174. DOI: 10.1038/s41598-023-28295-8
9. Debisarun P.A., Gössling K.L., Bulut O., Kilic G., Zoodsma M., Liu Z., Oldenburg M., Rüchel N., Zhang B., Xu C.J., Struycken P., Koeken VACM., Domínguez-Andrés J., Moorlag SJCFM., Taks E., Ostermann P.N., Müller L., Schaal H., Adams O., Borkhardt A., Ten O.J., Crevel R., Li Y., Netea M.G. Induction of trained immunity by influenza vaccination – impact on COVID-19. PLoS Pathog., 2021, Vol. 17, no. 10. DOI: 10.1371/journal.ppat.1009928.
10. Ramakrishnan A., Althoff K.N., Lopez J.A., Coles C.L., Bream J.H. Differential serum cytokine responses to inactivated and live attenuated seasonal influenza vaccines. Cytokine., 2012, Vol. 60, no. 3, pp. 661-6. DOI: 10.1016/j.cyto.2012.08.004.
11. Talaat K.R., Halsey N.A., Cox A.B., Coles C.L., Durbin A.P., Ramakrishnan A., Bream J.H. Rapid changes in serum cytokines and chemokines in response to inactivated influenza vaccination. Influenza Other Respir Viruses., 2018, Vol. 12, no.2, pp. 202-210. DOI: 10.1111/irv.12509.
12. McDonald J.U., Zhong Z., Groves H.T., Tregoning J.S. Inflammatory responses to influenza vaccination at the extremes of age. Immunology., 2017, Vol. 151, no. 4, pp. 451-463. DOI: 10.1111/imm.12742.
13. Martin J.M., Avula R., Nowalk M.P., Lin C.J., Horne W.T., Chandran U.R., Nagg J.P., Zimmerman R.K., Cole K.S., Alcorn J.F. Inflammatory Mediator Expression Associated With Antibody Response Induced by Live Attenuated vs Inactivated Influenza Virus Vaccine in Children. Open Forum Infect Dis., 2018, Vol. 5, no. 11. DOI: 10.1093/ofid/ofy277. .
14. Bouwman W., Verhaegh W., Holtzer L., van de Stolpe A. Measurement of Cellular Immune Response to Viral Infection and Vaccination. Front Immunol., 2020, Vol. 11, no. 575074. DOI: 10.3389/fimmu.2020.575074.
15. Garcia-Gasalla M., Berman-Riu M., Rodriguez A., Iglesias A., Fraile-Ribot P.A., Toledo-Pons N., Pol-Pol E., Ferr -Beltrán A., Artigues-Serra F., Martin-Pena M.L., Pons J., Murillas J., Oliver A., Riera M., Ferrer J.M. Elevated complement C3 and increased CD8 and type 1 helper lymphocyte T populations in patients with post-COVID-19 condition. Cytokine., 2023, Vol. 169, no. 156295. DOI: 10.1016/j.cyto.2023.156295.
16. Kostinov M.P., Tyukavkina S.Yu., Kharseeva G.G., Nastaeva N.Yu. Efficiency of influenza vaccination in the context of the COVID-19 pandemic (material for preparing a lecture). Infectious diseases: news, opinions, training, 2023, Vol. 12, no. 4, pp. 90–99. DOI: 10.33029/2305-3496-2023-12-4-90-99
17. Khromova E.A., Akhmatova N.K., Kostinov M.P., Shodova S.A., Stolpnikova V.N., Vlasenko A.E., Polischuk V.B., Shmitko A.D. Effect of immunoadjuvant and non-adjuvant influenza vaccines on the immunophenotype of lymphocytes in vitro. Infection and immunity, 2023, Vol. 13, no. 3, pp. 430-438. DOI: 10.15789/2220-7619-TIO-1250
18. Khromova E.A., Semochkin I.A., Akhmatova E.A., et al. Influenza vaccines: effect on TLRs. Russian Journal of Immunology. Thematic issue “Kaliningrad Scientific Forum”, 2016, Vol. 10, no. 2-1, pp. 505-507.
19. Khromova E.E., Semochkin I.A., Akhmatova E.A., et al. Comparative activity of influenza vaccines: influence on the subpopulation structure of lymphocytes. Journal of Microbiology, Epidemiology and Immunobiology, 2016, no. 6, pp. 61–65. DOI: 10.36233/0372-9311-2016-6-61-65
20. Sokolova T.M., Shuvalov A.N., Poloskov V.V., et al. Vaccines “Grippol” and “Influvac” – inducers of genes of innate and adaptive immunity factors in human blood cells. Journal of Microbiology, Epidemiology and Immunobiology, 2014, no. , pp. 37-43.
21. Kostinov M., Akhmatova N., Khromova E. et al. Cytokine profi le in human peripheral blood mononuclear leukocytes exposed to immunoadjuvant and adjuvant-free vaccines against influenza. Front. Immunol., 2020, Vol. 11, Р. 1351. DOI: 10.3389/fimmu.2020.01351].
22. Smith D.J., Forrest S., Ackley D.H., Perelson A.S. Variable efficacy of repeated annual influenza vaccination. Proc Natl Acad Sci U S A., 1999, Vol. 96, no. 24. DOI: 10.1073/pnas.96.24.14001.
23. Plant E.P., Fredell L.J., Hatcher B.A., Li X., Chiang M.J., Kosikova M., Xie H., Zoueva O., Cost A.A., Ye Z., Cooper M.J. Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains. Sci Rep., 2017, Vol.7, no. 1. DOI: 10.1038/s41598-017-05579-4.
Review
For citations:
Li Yu.A., Dmitrachenko M.N., Kostinov M.P., Markelova E.V., Korolev I.V., Saprykin S.L. Influenza vaccination and cytokine profile dynamics in young men in Primorsky krai. Journal Infectology. 2024;16(4):78-84. (In Russ.) https://doi.org/10.22625/2072-6732-2024-16-4-78-84
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