ГЕНЕТИЧЕСКИЙ ПОЛИМОРФИЗМ ИММУНОГЕННОЙ СИГНАЛЬНОЙ СИСТЕМЫ
https://doi.org/10.22625/2072-6732-2011-3-2-21-27
Аннотация
Функциональные исследования выявили важное значение структурной целостности компонентов внутриклеточной сигнальной трансдукции системы врожденного иммунитета. Идентифицирована молекулярная структура ряда протеинов, участвующих в иммунном сигналинге, что способствует пониманию механизмов функционирования врожденного иммунитета на молекулярном уровне. Полиморфизмы, изменяющие сигнальную трансдукцию в клеточных элементах врожденного иммунитета и влияющие на предрасположенность человека к различным инфекциям, являются еще одним доказательством роли генетического фона хозяина в патофизиологии инфекционных заболеваний или резистентности к ним. В лекции описаны полиморфизмы молекул, вовлеченных в иммуногенный сигналинг, которые ассоциированы с продукцией провоспалительных цитокинов и эффективностью иммунных реакций.
Об авторах
В. Н. ЦыганРоссия
начальник научно-исследовательского отдела Военно-медицинской академии им. С.М. Кирова, д.м.н., профессор, тел. +7-911-950-23-50
А. М. Иванов
Россия
начальник отдела нанобиотехнологий НИЦ Военно-медицинской академии им. С.М. Кирова, д.м.н., профессор, тел. +7921-951-64-39
Т. А. Камилова
Россия
старший научный сотрудник лаборатории молекулярно-генетических исследований отдела нанобиотехнологий НИЦ Военно-медицинской академии им. С.М. Кирова, к.б.н., тел. +7921-637-46-51
Е. А. Кожухова
Россия
доцент кафедры инфекционных болезней Санкт-Петербургского государственного медицинского университета им. академика И.П. Павлова, к.м.н., тел.+7-905-221-05-98
Н. Н. Мурашкин
Россия
заведующий детским отделением ГУЗ «Клинический кожно-венерологический диспансер» департамента здравоохранения Краснодарского края, к.м.н., тел.+7-918-495-11-22
Н. В. Цыган
Россия
преподаватель кафедры нервных болезней Военно-медицинской академии, к.м.н., тел.+7-921-928-94-70
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Рецензия
Для цитирования:
Цыган В.Н., Иванов А.М., Камилова Т.А., Кожухова Е.А., Мурашкин Н.Н., Цыган Н.В. ГЕНЕТИЧЕСКИЙ ПОЛИМОРФИЗМ ИММУНОГЕННОЙ СИГНАЛЬНОЙ СИСТЕМЫ. Журнал инфектологии. 2011;3(2):21-27. https://doi.org/10.22625/2072-6732-2011-3-2-21-27
For citation:
Tzygan V.N., Ivanov A.M., Kamilova T.A., Коjuhova E.A., Мurashkin N.N., Tsygan N.V. Genetic polymorphism of immunogenic signaling system. Journal Infectology. 2011;3(2):21-27. (In Russ.) https://doi.org/10.22625/2072-6732-2011-3-2-21-27