КРИОГЛОБУЛИНЕМИЯ И ВИРУС ГЕПАТИТА С


https://doi.org/10.22625/2072-6732-2011-3-2-15-20

Полный текст:


Аннотация

В обзоре представлены последние данные о криоглобулинемии, ассоциированной с вирусом гепатита С: частота встречаемости, патогенез, клинические проявления, лабораторная диагностика, подходы к терапии.


Об авторах

Н. В. Дунаева
ФГБУ НИИ гриппа Минздравсоцразвития России, Санкт-Петербург
Россия

старший научный сотрудник отделения клинико-экспериментальных исследований Научно-исследовательского института гриппа Минздравсоцразвития России, к.м.н., тел. 8-921-741-88-20, факс 8(812)234-12-38



Е. В. Эсауленко
Санкт-Петербургская государственная педиатрическая медицинская академия, Санкт-Петербург
Россия

заведующая кафедрой инфекционных болезней взрослых и эпидемиологии Санкт-Петербургской государственной педиатрической медицинской академии, д.м.н., профессор, тел./факс 8(812)234-12-38



Список литературы

1. Choo, Q.L. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome / Q.L. Choo [et al.] // Science. – 1989. – V. 244, № 4902. – P. 359–362.

2. Вирусные гепатиты: клиника, диагностика, лечение /Ю.В. Лобзин [и др.]. – СПб: ООО «Издательство ФОЛИАНТ», 2006. – 192 с.

3. D'Amico, G. Cryoglobulinemia / G. D'Amico, A. Fornasieri ed. by H.R. Brady, C.S. Wilcox // Therapy in nephrology and hypertension: a companion to Brenner and Rector's The kidney. – USA: W.B. Saunders Company, 1999. – Chap.18. – P. 125–129.

4. Wintrobe, M. Hyperproteinemia associated with multiple myeloma. With report of a case in with anextraordinary hyperproteinemia was associated with thrombosis of the retinal veins and symptoms suggesting Raynaud’s disease /M. Wintrobe, M. Buell // Bulletin of the John Hopkins Hospital. – 1933. – V. 52. – P. 156–165.

5. Lerner, V. Studies of cryoglobulins. I. Unusual purpura associated with the presence of high concentration of cryoglobulin (cold precipitable serum globulin) / V. Lerner, G. Watson // Am. J. Med. Sci. – 1947. – V. 314. – P. 410–415.

6. Brouet, J.C. Biological and clinical significance of crioglobulins: a report of 86 cases / J.C. Brouet [et al.] // Am. J. Med. – 1974. – V. 57. – P. 775–788.

7. Константинова, Н. А. Криоглобулины и патология /Н.А. Константинова. – М.: Медицина, 1999. – 176 с.

8. Saadoun, D. Increased risks of lymphoma and death among patients with non–hepatitis C virus– elated mixed cryoglobulinemia / D. Saadoun [et al.] // Arch. Intern. Med. – 2006. – V. 166, № 19. – P. 2101–2108.

9. Foessel, L. Clinical spectrum, treatment, and outcome of patients with type II mixed cryoglobulinemia without evidence of hepatitis C infection / L. Foessel [et al.] // J. Rheumatol. –2011. – V. 38, № 4. – P. 716–722.

10. Trejo, O. Hematologic malignancies in patients with cryoglobulinemia: association with autoimmune and chronic viral diseases / O. Trejo [et al.] // Semin. Arthritis Rheum. – 2003. – V. 33, № 1. – P. 19–28.

11. Rizos, E. Cryoglobulinemic purpura in visceral leishmaniasis / E. Rizos [et al.] // Rheumatol. Int. – 2005. – V. 25, № 6. – P. 469–471.

12. Kosmas, N. Decreased prevalence of mixed cryoglobulinemia in the HAART era among HIV-positive,

13. HCV-negative patients / N. Kosmas [et al.] // J. Med. Virol. – 2006. – V. 78, № 10. – P. 1257–1261.

14. Scotto, G. Cryoglobulinemia in subjects with HCV infection alone, HIV infection and HCV/HIV coinfection / G. Scotto [et al.] // J. of Infection. – 2006. – V. 52, № 4. – P. 294–299.

15. Almirall, J. Type II essential mixed cryoglobulinemia and renal disease. Hepatitis C virus association / J. Almirall [et al.] // Nefrologia. – 2002. – V. 22, № 6. – P. 531–539.

16. Mascia, M.T. Non HCV-related mixed cryoglobulinemia /M.T. Mascia [et al.] // Digestive and liver disease. – 2007. – V. 39, Suppl 1. – Р. 61–64.

17. Pascual, M. Hepatitis C virus in patients with cryoglobulinaemia type II / M. Pascual [et al.] // J. Infect. Dis. – 1990. – V. 162. – P. 569–570.

18. Дунаева, Н.В. Распространённость и факторы риска развития криоглобулинемии, ассоциированной с хроническим гепатитом С / Н.В. Дунаева [и др.] // Медицинская иммунология. – 2007. – Т. 9, № 6. – С. 575–580.

19. Иванова, И.В. Вовлечение почек в патологический процесс при HCV инфекции / И.В. Иванова [и др.] // Проблема инфекции в клинической медицине : мат. науч. конф. – СПб.: ВМедА, 2003. – С. 138.

20. Lunel, F. Cryoglobulinemia in chronic liver diseases: role of hepatitis C virus and liver damage / F. Lunel [et al.] //Gastroenterology. – 1994. – V. 106, № 5. – P. 1291–1300.

21. Pawlotsky, J.-M. Immunological disorders in C virus chronic active hepatitis: a prospective case-control study /J.-M. Pawlotsky [et al.] // Hepatology. – 1994. – V.19, № 4. – P. 841–848.

22. Wong, V.S. Incidence, character and clinical relevance of mixed cryoglobulinemia in patients with chronic hepatitis C virus infection / V.S. Wong [et al.] // Clin. Exp. Immunol. – 1996. – V. 104, № 1. – P. 25–31.

23. Hwang, S.-J. Genetic predispositions for the presence of cryoglobulinemia and serum autoantibodies in Chinese patients with chronic hepatitis C / S.-J. Hwang [et al.] // Tissue Antigens. – 2002. – V. 59. – P. 31–37.

24. Liakina, V. Prevalence of cryoglobulinemia in patients with chronic HCV infection / V. Liakina [et al.] // Med. Sci. Monit. – 2002. – V. 8, № 1. – P. 31–36.

25. Iagnocco, A. Joint sonographi in asymptomatic patients with HCV correlated hepatitis / A. Iagnocco [et al.] // Clin. Exp. Rheumatology. – 2004. – V. 22, № 1. – P. 43–48.

26. Viganò, M. Natural history and clinical impact of cryoglobulins in chronic hepatitis C: 10-year prospective study of 343 patients / M. Viganò [et al.] // Gastroenterology. – 2007. – V. 133, № 3. – P. 835–842.

27. Vigani, A.G. The association of cryoglobulinaemia with sustained virological response in patients with chronic hepatitis C / A.G. Vigani [et al.] // J. Viral. Hepat. – 2011. – V. 18, № 4. – Р. 91–98.

28. Kayali, Z. Hepatitis C, cryoglobulinemia, and cirrhosis: a meta-analysis / Z. Kayali [et al.] // Hepatology. – 2002. – V. 36, № 4. – P. 978–985.

29. Gad, A. Factors predisposing to the occurrence of cryoglobulinemia in two cohorts of Egyptian and Japane sepatients with chronic hepatitis C infection: ethnic and genotypic influence / A. Gad [et al.] // J. Med. Virol. – 2003. – V. 70, № 4. – P. 594–599.

30. Muratori, L. Quantification of hepatitis C virusinfected peripheral blood mononuclear cells by in situ reverse transcriptase-polymerase chain reaction / L. Muratori [et al.] // Blood. – 1996. – V. 88, № 7. – P. 2768–2774.

31. Ferri, C. HCV-related cryoglobulinemic vasculitis: an update on its etiopathogenesis and therapeutic strategies / C. Ferri [et al.] // Clin. Exp. Rheumatol. – 2003. – V. 21, Suppl. 31. – Р. 78–84.

32. Kronenberger, B. Interferon alfa down-regulates CD81 in patients with chronic hepatitis C / B. Kronenberger [et al.] // Hepatology. – 2001. – V. 33, № 6. – P. 1518–1526.

33. Вишневская, Т.В. Выявление маркёров репликации вируса гепатита С в мононуклеарных клетках периферической крови больных хроническим гепатитом С / Т.В. Вишневская [и др.] // Медицинская иммунология. – 2008. – Т. 10, № 4–5. – С. 397–404.

34. Moldvay, J. Detection of hepatitis C virus RNA in peripheral blood mononuclear cells of infected patients by in situ hybridization / J. Moldvay [et al.] // Blood. – 1994. – V. 83, № 1. – P. 269–273.

35. Morsica, G. Replication of hepatitis C virus in B lymphocytes (CD19+) / G. Morsica [et al.] // Blood. –1999. – V. 94, № 3. – P. 1138–1139.

36. Ducoulombier, D. Frequent compartmentalization of hepatitis C virusvariants in circulating B cells and monocytes / D. Ducoulombier [et al.] // Hepatology. – 2004. – V. 39, № 3. – P. 817–825.

37. Agnello, V. The etiology and pathophysiology of mixed cryoglobulinemia secondary to hepatitis C virus infection /V. Agnello // Springer Semin. Immunopathol. – 1997. – V. 19, № 1. – P. 111–129.

38. Ivanovski, M. Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/ VLkv325 immunoglobulin gene combination in hepatitis C virus – associated immunocytomas / M. Ivanovski [et al.] // Blood. – 1998. – V. 91, № 7. – P. 2433–2442.

39. Zignego, A. Prevalence of bcl-2 rearrangement in patients with chronic hepatitis C virus- related mixed cryoglobulinemia with or without B-cell lymphomas / A. Zignego [et al.] // Ann. Intern. Med. – 2002. – V. 137, № 7. – P. 571–580.

40. Kitay-Cohen, Y. Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II / Y. Kitay-Cohen [et al.] // Blood. – 2000. – V. 96, № 8. – P. 2910–2912.

41. Zignego, A.L. T(14;18) translocation in chronic hepatitis C virus infection / A.L. Zignego [et al.] // Hepatology. – 2000. – V. 31, № 2. – P. 474–479.

42. Giannelli, F. Effect of antiviral treatment in patients with chronic HCV infection and t(14;18) translocation / F. Giannelli [et al.] // Blood. – 2003. – V. 102, № 4. – P. 1196–1201.

43. Sebastiani, G.D. Association of extrahepatic manifestations with HLA class II alleles and with virus genotype in HCV infected patients / G.D. Sebastiani [et al.] // J. Biol. Regul. Homeost. Agents. – 2005. – V. 19, № 1–2. – Р. 17–22.

44. Vassilopoulos, D. Study of host and virological factors of patients with chronic HCV infection and associated laboratory or clinical autoimmune manifestations / D. Vassilopoulos [et al.] // Clin. Exp. Rheumatol. – 2003. – V. 21, № 6 (Suppl. 32). – Р. 101–111.

45. Sutton, B. The structure and origin of rheumatoid factors / B. Sutton [et al.] // Immunol. Today. – 2000. – V. 21, № 4. – P. 177–183.

46. Toubi, E. IgA rheumatoid factor in patients with chronic HCV infection: prevalence and clinical correlations / E. Toubi [et al.] // Clin. Exp. Rheumatol. – 2003. – Vol. 21, № 4. – P. 524.

47. Gorevic, P.D. Mixed cryoglobulinemia cross-reactive idiotypes: implications for the relationsship of MC to rheumatic and lymphoproliferative disease / P.D. Gorevic, B. Frangione // Semin. Hematol. – 1991. – V. 28, № 2. – P. 79–94.

48. Sansonno, D. Detection and distribution of hepatitis C virus-related ptoteins in lymph nodes of patients with type II mixed cryoglobulinemia and neoplastic non- neoplastic lymphoproliferation / D. Sansonno [et al.] // Blood. – 1996. – V. 88, № 12. – P. 4638–4645.

49. Fornasieri, A. Type II mixed cryoglobulinaemia, hepatitis C virus infection, and glomerulonephritis / A. Fornasieri, G. D’Amigo // Nephrol. Dial. Transplant. – 1996. – V. 11, Suppl. 4. – P. 25–30.

50. Sansonno, D. Hepatitis C virus-related proteins in kidney tissue from hepatitis C virus-infected patients with cryoglobulinemic membranoproliferative glomerulonephritis /D. Sansonno [et al.] // Hepatology. – 1997. – V. 25, № 5. – P. 1237–1244.

51. Козловская, Л.В. Факторы риска прогрессирования криоглобулинемического гломерулонефрита, связанного с вирусом гепатита С / Л.В. Козловская [и др.] // Клин. медицина. – 2001. – № 4. – С. 32–35.

52. Hilgard, P. Cryoglobulin-associated uptake of hepatitis C virus into human hepatocytes / P. Hilgard

53. [et al.] // Hepato-gastroenterology. – 2005. – V. 52, № 65. – P. 1534–1540.

54. Schmidt, W.N. Hepatitis C virus (HCV) infection and cryoglobulinemia: analysis of whole blood and plasma HCV-RNA concentrations and correlation with liver histology / W.N. Schmidt [et al.] // Hepatology. – 2000. – V. 31, № 3. – P.737–744.

55. Saadoun, D. Cryoglobulinemia is associated with steatosis and fibrosis in chronic hepatitis C / D. Saadoun [et al.] //Hepatology. – 2006. – V. 43, № 6. – P. 1337–1345.

56. Siagris, D. Cryoglobulinemia and progression of fibrosis in chronic HCV infection: cause or effect? / D.Siagris [et al.] //J. of Infection. – 2004. – V. 49, № 3. – P. 236–241.

57. Чернецова, О.В. Cиндром Шегрена при хроническом гепатите С: клинические особенности и диагностика / О.В. Чернецова [и др.] // Тер. архив. – 2003. – № 4. – С. 33–37.

58. Sabry, A.A. A comprehensive study of the association between hepatitis C virus and glomerulopathy / A.A. Sabry [et al.] // Nephrol. Dial. Transplant. – 2002. – V. 17, № 2. – P. 239–245.

59. Lamprecht, P. Prevalence of ANCA in mixed cryoglobulinemia and chrinic hepatitis C virus infection /P. Lamprecht [et al.] // Clin. Exp. Rheumatol. – 2003. – V. 21, № 6 (Suppl. 32). – Р. 89–94.

60. Cappellari, A. Central nervous system involvement in HCV-related mixed cryoglobulinemia / A. Cappellari, L. Origgi, M.F. Spina, K.G. Yiannopoulou, G. Meola, M. Vanoli, A. Ciammola, F. Gregorini, R. Scorza, N. Bresolin // Electromyography and clinical neurophysiology. – 2006. – V. 46, № 3. – P. 149–158.

61. Koskinas, J. Severe hepatitis C virus-related cryoglobulinaemic sensory-motor polyneuropathy treated with pegylated interferon-a2b and ribavirin: clinical, laboratory and neurophysiological study / J. Koskinas [et al.] // Liver. Int. – 2007. – V. 27, № 3. – P. 414–420.

62. Roccatello, D. Multicenter study on hepatitis C virusrelated cryoglobulinemic glomerulonephritis / D. Roccatello [et al.] // Am. J. Kidney Dis. – 2007. – V. 49, № 1. – P. 69–82.

63. Shibazaki, K. Paradoxical brain embolism associated with HCV-related type II mixed cryoglobulinemia / K. Shibazaki [et al.] // J. of clinical neuroscience. – 2007 – V. 14, № 8. – P. 780–782.

64. Agnello, V. Mixedcryoglobulinemia and other extrahepatic manifestation HCV infection / V. Agnello ; ed. by T.J. Liang, J.H. Hoofnagle // Hepatitis C. – San Diego, CA: Academic, 2000. – P. 295–313.

65. Дунаева, Н.В. Дисфункция почек у больных хроническим гепатитом С / Н.В. Дунаева [и др.] // Вестник НовГУ. – 2010. – № 59.– С. 96–100.

66. Неустроева, Ю.А. Оптимизация полуколичественного метода выявления криоглобулинов в условиях клинико-диагностической лаборатории / Ю.А. Неустроева [и др.] //Клин. лаб. диагностика. – 2007. – № 1. – С. 37–41.

67. Ferri, C. Low-antigen-content diet in the treatment of patients with mixed cryoglobulinemia / C. Ferri [et al.] // Am. J. Med. – 1989. – V. 87, № 5. – P. 519–524.

68. Tavoni, A. Guidelines for the management of essential mixed cryoglobulinemia / A. Tavoni [et al.] // Clin. Exp. Rheumatol. – 1995. – V. 13, Suppl. 13. – P. 191–195.

69. Misiani, R. Interferon alfa-2a therapy in cryoglobulinemia associated with hepatitis C virus / R. Misiani [et al.] // N. Engl. J. Med. – 1994. – V. 330, № 11. – P. 751–756.

70. Dammaco, F. Natural interferon-alfa versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study / F. Dammaco [et al.] // Blood. – 1994. – V. 84, № 10. – P. 3336–3343.

71. McHutchinson, J.G. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C / J.G. McHutchinson [et al.] // N. Engl. J. Med. –1998. – V. 339, № 19. – P. 1485–1492.

72. Zeuzem, S. Peginterferon Alfa-2a in patients with chronic hepatitis C / S. Zeuzem [et al.] // N. Engl. J. Med. – 2000. – V. 343, № 23. – P. 1666–1672.

73. Manns, M.P. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial / M.P. Manns [et al.] // Lancet. – 2001. – V. 358, № 9286. – P. 958– 965.

74. Fried, M.W. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection / M.W. Fried [et al.] //N. Engl. J. Med. – 2002. V. 347, № 13. – P. 975–982.

75. Witthöft, T. Safety, tolerability and efficacy of peginterferon alpha-2a and ribavirin in chronic hepatitis C in clinical practice: the German open safety trial / T. Witthöft [et al.] // J. of Viral Hepatitis. – 2007. – V. 14, № 11. – P. 788– 796.

76. Davis, G.L. Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C / G.L. Davis [et al.] // N. Engl. J. Med. – 1998. – V. 339, № 21. –P. 1493–1499.

77. Alric, L. Influence of antiviral therapy in hepatitis C virus-associated cryoglobulinemic MPGN / L. Alric [et al.] //Am. J. of Kidney Dis. – 2004. – V. 43, № 4. – P. 617–623.

78. Zuckerman, E. The effect of antiviral therapy on t(14;18) translocation and immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection / E. Zuckerman [et al.]// Blood. – 2001. – V. 97, № 6. – P. 1555–1559.

79. Фрейдлин, И.С. Клетки иммунной системы III-V /И.С. Фрейдлин, А.А. Тотолян. – М.: Наука, 2001. – 390 с.

80. Sansonno, D. Monoclonal antibody treatment of mixed cryoglobulinemia resisitant to interferon alfa with an anti CD-20 / D. Sansonno [et al.] // Blood. – 2003. – V. 101, № 10. P. 3818–3826.

81. Quartuccio, L. Rituximab treatment for glomerulonephritis in HCV-associated mixed cryoglobulinaemia: efficacy and safety in the absence of steroids / L. Quartuccio [et al.] // Rheumatology (Oxford). – 2006. – V. 45, № 7. – P. 842–846.


Дополнительные файлы

Для цитирования: Дунаева Н.В., Эсауленко Е.В. КРИОГЛОБУЛИНЕМИЯ И ВИРУС ГЕПАТИТА С. Журнал инфектологии. 2011;3(2):15-20. https://doi.org/10.22625/2072-6732-2011-3-2-15-20

For citation: Dunaeva N.V., Esaulenko E.V. Cryoglobulinemia and hepatitis C virus. Journal Infectology. 2011;3(2):15-20. (In Russ.) https://doi.org/10.22625/2072-6732-2011-3-2-15-20

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