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Систематический обзор. Современные представления об инфекции, вызываемой Betapolyomavirus hominis

https://doi.org/10.22625/2072-6732-2023-15-2-24-34

Аннотация

Реактивация Betapolyomavirus hominis (BKPyV) у реципиентов почки и гемопоэтических стволовых клеток может приводить к серьезным осложнениям в виде BKPyV-ассоциированной нефропатии с последующим отторжением трансплантата и BKPyV-ассоциированного геморрагического цистита. Раннюю диагностику заболевания затрудняет возможное сочетание BKPyV-инфекции с другими патологиями посттрансплантационного периода и отсутствие специфической симптоматики. Репликация BKPyV на данный момент является единственным достоверным маркером развития отдаленных последствий, поэтому ведение пациентов основано на мониторинге концентрации вирусной ДНК. Однако согласованность между результатами определения вирусной нагрузки и развития осложнений посттрасплантационного периода, связанных с реактивацией BKPyV, не может быть достигнута без эффективных средств стандартизации лабораторного исследования.

Данный обзор охватывает текущее понимание эпидемиологии вируса, патогенеза и клинических особенностей заболеваний, ассоциированных с BKPyV, а также подробно рассматривает современные методы лабораторной диагностики BKPyV-инфекции.

Об авторах

Д. Р. Прилепская
Центральный научно-исследовательский институт эпидемиологии
Россия

Прилепская Диана Ринатовна – научный сотрудник научной группы разработки новых методов диагностики оппортунистических и папилломавирусных инфекций отдела молекулярной диагностики и эпидемиологии; тел.: 8(495) 974-96-46 доб. 2329

Москва



Э. А. Домонова
Центральный научно-исследовательский институт эпидемиологии
Россия

Домонова Эльвира Алексеевна – руководитель научной группы разработки новых методов диагностики оппортунистических и папилломавирусных инфекций отдела молекулярной диагностики и эпидемиологии, к.б.н.; тел.: +7(495) 974-96-46 доб. 1141

Москва



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Рецензия

Для цитирования:


Прилепская Д.Р., Домонова Э.А. Систематический обзор. Современные представления об инфекции, вызываемой Betapolyomavirus hominis. Журнал инфектологии. 2023;15(2):24-34. https://doi.org/10.22625/2072-6732-2023-15-2-24-34

For citation:


Prilepskaya D.R., Domonova E.A. A systematic review. Current understanding of the infection caused by Betapolyomavirus hominis. Journal Infectology. 2023;15(2):24-34. (In Russ.) https://doi.org/10.22625/2072-6732-2023-15-2-24-34

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