jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2023-15-2-24-34jofin-1501Research ArticleОбзорReviewСистематический обзор. Современные представления об инфекции, вызываемой Betapolyomavirus hominisA systematic review. Current understanding of the infection caused by Betapolyomavirus hominisПрилепскаяД. Р.PrilepskayaD. R.

Прилепская Диана Ринатовна – научный сотрудник научной группы разработки новых методов диагностики оппортунистических и папилломавирусных инфекций отдела молекулярной диагностики и эпидемиологии; тел.: 8(495) 974-96-46 доб. 2329

Москва

Moscow

prilepskaya.d@cmd.suДомоноваЭ. А.DomonovaE. A.

Домонова Эльвира Алексеевна – руководитель научной группы разработки новых методов диагностики оппортунистических и папилломавирусных инфекций отдела молекулярной диагностики и эпидемиологии, к.б.н.; тел.: +7(495) 974-96-46 доб. 1141

Москва

Moscow

elvira.domonova@pcr.msЦентральный научно-исследовательский институт эпидемиологииРоссияCentral Research Institute of EpidemiologyRussian Federation2023060720231522434Copyright © Прилепская Д.Р., Домонова Э.А., 20232023Прилепская Д.Р., Домонова Э.А.Prilepskaya D.R., Domonova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/1501

Реактивация Betapolyomavirus hominis (BKPyV) у реципиентов почки и гемопоэтических стволовых клеток может приводить к серьезным осложнениям в виде BKPyV-ассоциированной нефропатии с последующим отторжением трансплантата и BKPyV-ассоциированного геморрагического цистита. Раннюю диагностику заболевания затрудняет возможное сочетание BKPyV-инфекции с другими патологиями посттрансплантационного периода и отсутствие специфической симптоматики. Репликация BKPyV на данный момент является единственным достоверным маркером развития отдаленных последствий, поэтому ведение пациентов основано на мониторинге концентрации вирусной ДНК. Однако согласованность между результатами определения вирусной нагрузки и развития осложнений посттрасплантационного периода, связанных с реактивацией BKPyV, не может быть достигнута без эффективных средств стандартизации лабораторного исследования.

Данный обзор охватывает текущее понимание эпидемиологии вируса, патогенеза и клинических особенностей заболеваний, ассоциированных с BKPyV, а также подробно рассматривает современные методы лабораторной диагностики BKPyV-инфекции.

Reactivation of Betapolyomavirus hominis (BKPyV) in kidney and hematopoietic stem cell recipients can lead to serious complications such as BKPyV-associated nephropathy followed by transplant rejection and BKPyV-associated hemorrhagic cystitis. Early diagnosis of the disease is hampering by the possible combination of infection of BKPyV with other post-transplant pathologies and the absence of specific symptoms. Replication of BKPyV is currently the only reliable prognostic sign of the development of long-term consequences, so patient management is basseting on monitoring the concentration of viral DNA. However, consistency between the results of determining the viral load and the development of post-transplant complications associated with BKPyV reactivation cannot be achieving without effective means of standardizing laboratory testing. This review covers the current understanding of the epidemiology; pathogenesis and the clinical features of the disease associated with BKPyV, and also considers in detail the current methods of laboratory diagnosis infection of BKPyV.

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The authors declare that there are no conflicts of interest present.