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Changes in serotype distribution of Streptococcus pneumonia circulating among children in the Russian Federation after 13-valent pneumococcal conjugate vaccine introduction.

https://doi.org/10.22625/2072-6732-2023-15-2-6-13

Abstract

During a prospective multicenter non-interventional observational study, a comparative assessment was made of the serotype structure of pneumococci circulating among healthy children under the age of 5 years and children of the same age group with signs of respiratory infections in the periods 2016-2018 and 2020-2022. Data on the serotype structure of pneumococci in the period from 2016-2018 were obtained from our previous works. In 2020-2022 the study included 2066 healthy children and 603 children with respiratory infections. Streptococcus pneumoniae and their DNA were detected in nasopharyngeal swabs by classical culture and molecular methods. Typing was carried out by molecular methods. On the territory of the Russian Federation, pneumococci belonging to the serotypes included in the 13-valent vaccine are being forced out of circulation and replaced by non-vaccine serotypes. Before the introduction of mass antipneumococcal vaccination (until 2015), the 13-valent conjugate vaccine covered from 66.2% to 92% of pneumococci, after the start of mass anti-pneumococcal vaccination in the period 2016-2018, coverage decreased to 57.3%. Between 2020 and 2022, coverage was less than 40%. The main “non-vaccine” serotypes/serogroups circulating in the Russian Federation are 15AF, 11AD, 23A, 9LN and 16F.

About the Authors

S. V. Sidorenko
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation

Saint-Petersburg 


Yu. V. Lobzin
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation

Saint-Petersburg 


W. Rennert
Foundation of Rostropovich and Vishnevskaya and Georgetown University Hospital
United States

Washington


E. V. Nikitina
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation

Saint-Petersburg 


I. A. Tsvetkova
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation

Saint-Petersburg 


V. A. Ageevets
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation

Saint-Petersburg 


E. A. Martens
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation

Saint-Petersburg 


O. S. Kalinogorskaya
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation

Saint-Petersburg 


A. T. Ardysheva
Perm Clinical Center
Russian Federation

Perm 


L. T. Bayazitova
Kazan State Medical University
Russian Federation

Kazan 


A. V. Bikmieva
Perm State Medical University named after E.A. Vagner
Russian Federation

Perm 


E. V. Bolgarova
Federal Research Institute of Virus Infections «Virom»
Russian Federation

Yekaterinburg 


E. A. Brzhozovska
Russian National Research Medical University named after N.I. Pirogov
Russian Federation

Moscow 


I. V. Verentsova
Regional Clinical Hospital
Russian Federation

Khanty-Mansiysk 


A. A. Girina
Khanty-Mansiysk State Medical Academy
Russian Federation

Khanty-Mansyisk 


Yu. A. Zakharova
Federal Scientific Center for Hygiene named after F.F. Erisman
Russian Federation

Moscow 


T. V. Illarionova
Privolzhsky Research Medical University
Russian Federation

 Nizhny Novgorod 


G. Sh. Isaeva
Kazan State Medical University
Russian Federation

Kazan 


A. V. Klimashina
Khanty-Mansiysk State Medical Academy
Russian Federation

Khanty-Mansyisk 


O. V. Kovalishena
Privolzhsky Research Medical University
Russian Federation

Nizhny Novgorod 


T. G. Kozeeva
Perm Clinical Center
Russian Federation

Perm 


N. A. Mayansky
Russian National Research Medical University named after N.I. Pirogov
Russian Federation

Moscow 


I. A. Nemirovchenko
Privolzhsky Research Medical University
Russian Federation

Nizhny Novgorod 


I. V. Pozdeeva
Regional Clinical Hospital
Russian Federation

Khanty-Mansiysk 


V. A. Salina
Privolzhsky Research Medical University
Russian Federation

Nizhny Novgorod 


N. A. Sokolova
Perm Clinical Center
Russian Federation

Perm 


L. V. Tomracheva
Khanty-Mansiysk State Medical Academy
Russian Federation

Khanty-Mansyisk 


Yu. A. Tyurin
Kazan State Medical University
Russian Federation

Kazan 


I. V. Feldblyum
Perm State Medical University named after E.A. Vagner
Russian Federation

Perm 


I. Yu. Shirokova
Privolzhsky Research Medical University
Russian Federation

Nizhny Novgorod 


S. M. Skripkovskaya
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation

Saint-Petersburg 


A. E. Aleksandrova
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation

Saint-Petersburg 


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Review

For citations:

Sidorenko S.V., Lobzin Yu.V., Rennert W., Nikitina E.V., Tsvetkova I.A., Ageevets V.A., Martens E.A., Kalinogorskaya O.S., Ardysheva A.T., Bayazitova L.T., Bikmieva A.V., Bolgarova E.V., Brzhozovska E.A., Verentsova I.V., Girina A.A., Zakharova Yu.A., Illarionova T.V., Isaeva G.Sh., Klimashina A.V., Kovalishena O.V., Kozeeva T.G., Mayansky N.A., Nemirovchenko I.A., Pozdeeva I.V., Salina V.A., Sokolova N.A., Tomracheva L.V., Tyurin Yu.A., Feldblyum I.V., Shirokova I.Yu., Skripkovskaya S.M., Aleksandrova A.E. Changes in serotype distribution of Streptococcus pneumonia circulating among children in the Russian Federation after 13-valent pneumococcal conjugate vaccine introduction. Journal Infectology. 2023;15(2):6-13. (In Russ.) https://doi.org/10.22625/2072-6732-2023-15-2-6-13

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