Efficacy of COVID-19 vaccination in organized group: results of a prospective study
https://doi.org/10.22625/2072-6732-2022-14-5-35-40
Abstract
Objective: to assess the efficacy of COVID-19 vaccination against in organized group.
Materials and methods: A total of 122 adults, employees of a higher education institution participated in the study. Study participants were observed prospectively and filled out a questionnaire where they indicated their age, presence of chronic diseases, history of COVID-19 and vaccination status.
Findings: the study participants were divided into two groups: 59 vaccinated (48.36 %) and 63 unvaccinated (51.64 %) individuals with no differences in age between the groups. There were significantly fewer confirmed cases of COVID-19 in the vaccinated group (р = 0,0008457, df = 1; χ2 = 11,138), significant differences (p = 0.0084; df = 4; χ2 =13.678) were observed in the number of cases among study participants based on their vaccination status.
Conclusion: participants diagnosed with pneumonia were 75 % unvaccinated (p = 0,00729; df = 1; χ2 = 7,2). All hospitalized study participants were unvaccinated (p = 0,004678; χ2 =8,0). None of the vaccinated participants needed respiratory support (p = 0,0455; df = 1; χ2 = 4,0). Chronic disease in vaccinated subjects made a significant (p = 0,04563; df = 2; χ2 = 6,1743) impact on COVID-19 severity.
About the Authors
I. O. Stoma
Gomel State Medical University
Belarus
Belarus
Gomel
E. S. Korsak
Gomel State Medical University
Belarus
Belarus
Gomel
E. V. Voropaev
Gomel State Medical University
Belarus
Belarus
Gomel
O. V. Osipkina
Gomel State Medical University
Belarus
Belarus
Gomel
A. A. Kovalev
Gomel State Medical University
Belarus
Belarus
Gomel
O. L. Tumash
Gomel State Medical University
Belarus
Belarus
Gomel
D. D. Redko
Gomel State Medical University
Belarus
Belarus
Gomel
References
1. Röltgen K., Nielsen S. C. A., Silva O., Younes S. F., Zaslavsky M., Costales C. et al. Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination // Cell. 2022. Vol. 185 № 6 P.1025-1040.e14. doi: 10.1016/j.cell.2022.01.018
2. Nka A. D., Ka’e A. C., Bouba Y., Ngoufack Jagni Semengue E., Tommo Tchouaket M. C., Takou D. et al. Global burden of SARS-CoV-2 infection, hospitalization and case fatality rate among COVID-19 vaccinated individuals and its associated factors: A systematic review and meta-analysis protocol // PLoS One. 2022 Vol. 17 № 8 P. e0272839. doi: 10.1371/journal.pone.0272839
3. Moghadas S.. M., Vilches T. N., Zhang K., Wells C. R., Shoukat A., Singer B. H., Meyers L. A., Neuzil K. M., Langley J. M., Fitzpatrick M. C., Galvani A. P. The impact of vaccination on COVID-19 outbreaks in the United States // medRxiv [Preprint]. 2021. Vol. 2. P. 2020. 11. 27. 2024 0051. doi: 10.1101/2020.11.27.20240051. Update in: Clinical Infectious Diseases. 2021. Vol. 16 № 73 (12) P. 2257-2264.
4. Nordström P., Ballin M., Nordström A. Risk of infection, hospitalisation, and death up to 9 months after a second dose of COVID-19 vaccine: a retrospective, total population cohort study in Sweden // Lancet. 2022. Vol. 26 № 399 (10327). P. 814-823. doi: 10.1016/S0140-6736(22)00089-7.
5. Beeraka N. M, Sukocheva O. A., Lukina E., Liu J., Fan R. Development of antibody resistance in emerging mutant strains of SARS CoV-2: Impediment for COVID-19 vaccines // Reviews in Medical Virology. 2022. P. 13:e2346. Epub ahead of print. doi: 10.1002/rmv.2346.
6. Lee C. J., Woo W., Kim A. Y., Yon D. K., Lee S. W., Koyanagi A. Clinical manifestations of COVID-19 breakthrough infections: A systematic review and meta-analysis // J. Med. Virol. 2022. Vol. 94. № 9. P. 4234–4245. doi: 10.1002/jmv.27871
7. Stepanova M., Lam B., Younossi E., Felix S., Ziayee M., Price J. et al. The impact of variants and vaccination on the mortality and resource utilization of hospitalized patients with COVID-19 // BMC Infect. Dis. 2022. Vol. 22 P. 702. doi: 10.1186/s12879-022-07657-z
8. Wickham H., Averick M., Bryan J., Chang W., McGowan L. D., François R., Grolemund G., Hayes A., Henry L., Hester J., Kuhn M., Pedersen T. L., Miller E., Bache S. M., Müller K., Ooms J., Robinson D., Seidel D. P., Spinu V., Takahashi K., Vaughan D., Wilke C., Woo K., Yutani H. Welcome to the tidyverse // Journal of Open Source Software. 2019. Vol. 4 № 43. P. 1686. doi: 10.21105/joss.01686
9. Trajman A., Lachapelle-Chisholm S., Zikos T., Werneck G. L., Benedetti A. Efficacy and effectiveness of SARS-CoV-2 vaccines for death prevention: A protocol for a systematic review and meta-analysis // PLoS One. 2022. Vol. 17 № 7 P. e0265414. doi: 10.1371/journal.pone.0265414
10. Rodrigues C. M. C., Plotkin S. A. Impact of Vaccines; Health, Economic and Social Perspectives // Frontiers Microbiology. 2020. Vol. 14 № 11. P. 1526. doi: 10.3389/fmicb.2020.01526.
11. Stokel-Walker C. What do we know about covid vaccines and preventing transmission? // BMJ. 2022 Vol. 376. P. o298 doi: 10.1136/bmj.o298
12. Semenzato L., Botton J., Baricault B., Deloumeaux J., Joachim C., Sylvestre E. et al. Vaccine effectiveness against severe COVID-19 outcomes within the French overseas territories: A cohort study of 2-doses vaccinated individuals matched to unvaccinated ones followed up until September 2021 and based on the National Health Data System // PLoS ONE. 2022. Vol. 17 № 9. doi: 10.1371/journal.pone.0274309
13. Palmieri L., Floridia M., Giuliano M., Tiple D., Lo Noce C., Meli P. et al. Clinical characteristics of SARS-CoV-2 fullyvaccinated patients dying with COVID-19 in Italy // Clin. Microbiol. Infect. 2022. Vol. 28 № 6 P. 890–892. doi: 10.1016/j.cmi.2022.01.024
14. Fatima S., Zafar A., Afzal H., Ejaz T., Shamim S., Saleemi S. et al. COVID-19 infection among vaccinated and unvaccinated: Does it make any difference? // PLoS One. 2022. Vol. 17 № 7 P. e0270485. doi: 10.1371/journal.pone.0270485
15. Vokó Z., Kiss Z., Surján G., Surján O., Barcza Z., Pályi B. et al. Nationwide effectiveness of five SARS-CoV-2 vaccines in Hungary—the HUN-VE study // Clin. Microbiol. Infect. 2022. Vol. 28 № 3. P.398–404. doi: 10.1016/j.cmi.2021.11.011
16. Vokó Z., Kiss Z., Surján G., Surján O., Barcza Z., Wittmann I. Effectiveness and Waning of Protection With Different SARS-CoV-2 Primary and Booster Vaccines During the Delta Pandemic Wave in 2021 in Hungary (HUN-VE 3 Study) // Front. Immunol. 2022. Vol. 13 P. 919408. doi: 10.3389/fimmu.2022.919408
17. AlQahtani M., Du X., Bhattacharyya S., Alawadi A., Al Mahmeed H., Al Sayed J. et al. Post-vaccination outcomes in association with four COVID-19 vaccines in the Kingdom of Bahrain // Sci. Rep. 2022. Vol. 12. P. 9236. doi: 10.1038/s41598-022-12543-4
18. Scutt G., Cross M., Waxman D. Theoretically quantifying the direct and indirect benefits of vaccination against SARS-CoV-2 in terms of avoided deaths. Sci. Rep. 2022. Vol. 12 P. 8833. doi: 10.1038/s41598-022-12591-w
Review
For citations:
Stoma I.O., Korsak E.S., Voropaev E.V., Osipkina O.V., Kovalev A.A., Tumash O.L., Redko D.D. Efficacy of COVID-19 vaccination in organized group: results of a prospective study. Journal Infectology. 2022;14(5):35-40. (In Russ.) https://doi.org/10.22625/2072-6732-2022-14-5-35-40
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