State of immune status in hematological patients with invasive aspergillosis
https://doi.org/10.22625/2072-6732-2012-4-4-59-64
Abstract
Invasive aspergillosis – is severe mycotic infection that often occurs in hematological patients and is characterized by high mortality. We examined the immunological parameters of hematological patients with invasive aspergillosis developed after cytostatic chemotherapy. Was founded, disruption of all parts of the immune respons: reduction in the absolute number of T-helper cells (CD4 +), natural killer cells (CD16 +), lowering of IFN-γ and IL-10 production, reduction in the number of B-lymphocytes and immunoglobulin levels of all classes, suppression killer ability of neutrophils are features of immune status in hematological patients with invasive aspergillosis receiving cytostatic chemotherapy.
About the Authors
E. V. Frolova
Science Research Institute of Medical Mycology named after P.N. Kashkin of North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg
Russian Federation
Russian Federation
O. V. Shadrivova
North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg
Russian Federation
Russian Federation
L. V. Filippova
Science Research Institute of Medical Mycology named after P.N. Kashkin of North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg
Russian Federation
Russian Federation
A. E. Uchevatkina
Science Research Institute of Medical Mycology named after P.N. Kashkin of North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg
Russian Federation
Russian Federation
A. G. Volkova
Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after I.P. Pavlov, Saint-Petersburg
Russian Federation
Russian Federation
M. O. Popova
Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after I.P. Pavlov, Saint-Petersburg
Russian Federation
Russian Federation
L. S. Zubarovskaya
Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after I.P. Pavlov, Saint-Petersburg
Russian Federation
Russian Federation
I. S. Zjuzgin
Leningrad Regional Clinical Hospital, Saint-Petersburg
Russian Federation
Russian Federation
T. S. Bogomolova
Science Research Institute of Medical Mycology named after P.N. Kashkin of North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg
Russian Federation
Russian Federation
N. V. Vasilyeva
Science Research Institute of Medical Mycology named after P.N. Kashkin of North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg
Russian Federation
Russian Federation
B. V. Afanasyev
Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after I.P. Pavlov, Saint-Petersburg
Russian Federation
Russian Federation
N. N. Klimko
North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Frolova E.V., Shadrivova O.V., Filippova L.V., Uchevatkina A.E., Volkova A.G., Popova M.O., Zubarovskaya L.S., Zjuzgin I.S., Bogomolova T.S., Vasilyeva N.V., Afanasyev B.V., Klimko N.N. State of immune status in hematological patients with invasive aspergillosis. Journal Infectology. 2012;4(4):59-64. (In Russ.) https://doi.org/10.22625/2072-6732-2012-4-4-59-64
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