Endothelial activation markers (VCAM-1, vWF) in patients with chronic hepatitis C and insulin resistance
https://doi.org/10.22625/2072-6732-2012-4-4-46-51
Abstract
Blood markers of endothelial activation (sVCAM-1, vWF: Ag) in patients with chronic hepatitis C in the presence of insulin resistance, metabolic syndrome and its components had been evaluated. The study included 69 patients with chronic hepatitis C with oligosymptomatic the disease. In one third of cases of chronic hepatitis C (33.3%) showed improvement in the blood content of sVCAM-1 and / or vWF: Ag. In patients with chronic hepatitis C with insulin resistance, metabolic syndrome significantly more often found signs adhesion of endothelial dysfunction (increased blood concentrations of sVCAM-1) than in patients without these disorders. Found that in patients with severe hepatic fibrosis in patients with chronic hepatitis C blood concentration sVCAM-1 is significantly higher compared to patients with early stages of fibrosis (F0-F2), including those in patients without insulin resistance. These data suggest the multivariate development of endothelial dysfunction in chronic hepatitis C.
About the Authors
T. V. Antonova
Saint-Petersburg State Medical University named after academic I.P. Pavlov, Saint-Petersburg
Federal Centre of Heart, Blood and Endocrinology named after V.A. Almazov, Saint-Petersburg
Russian Federation
Russian Federation
M. A. Romanova
Saint-Petersburg State Medical University named after academic I.P. Pavlov, Saint-Petersburg
Russian Federation
Russian Federation
Yu. V. Lymar
Federal Centre of Heart, Blood and Endocrinology named after V.A. Almazov, Saint-Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Antonova T.V., Romanova M.A., Lymar Yu.V. Endothelial activation markers (VCAM-1, vWF) in patients with chronic hepatitis C and insulin resistance. Journal Infectology. 2012;4(4):46-51. (In Russ.) https://doi.org/10.22625/2072-6732-2012-4-4-46-51
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